Hi-JAKi-ng Synovial Fibroblasts in Inflammatory Arthritis With JAK Inhibitors

Selective Janus kinase inhibitors come of age

(2019) John J. O’Shea et al.   Nature Reviews Rheumatology

Baricitinib: The Second FDA-Approved JAK Inhibitor for the Treatment of Rheumatoid Arthritis

(2019) Amanda Mogul et al.   ANNALS OF PHARMACOTHERAPY

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications

(2019) Warren J. Leonard et al.   IMMUNITY

IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes

(2019) Michael Bonelli et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

JAK inhibitors for the treatment of autoimmune and inflammatory diseases

(2019) Yvan Jamilloux et al.   AUTOIMMUNITY REVIEWS

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition

(2018) Douglas S. Jones et al.   Science Signaling

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways

(2018) Maciej Czerkies et al.   Nature Communications

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

(2018) Thomas Karonitsch et al.   Cell Reports

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition

(2018) Douglas S. Jones et al.   Science Signaling

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

The role of the JAK/STAT signal pathway in rheumatoid arthritis

(2018) Charles J. Malemud   Therapeutic Advances in Musculoskeletal Disease

Upadacitinib for the treatment of rheumatoid arthritis

(2018) Lina Serhal et al.   Expert Review of Clinical Immunology

Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation

(2018) Guo-Juan Niu et al.   Frontiers in Immunology

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model

(2017) Misato Ito et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

The emerging safety profile of JAK inhibitors in rheumatic disease

(2017) Kevin L. Winthrop   Nature Reviews Rheumatology

Immunometabolism in early and late stages of rheumatoid arthritis

(2017) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Targeted inhibition of Janus kinases abates interfon gamma-induced invasive behaviour of fibroblast-like synoviocytes

(2017) Thomas Karonitsch et al.   RHEUMATOLOGY

Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model

(2017) Bruno Vidal et al.   RHEUMATOLOGY

Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK-1 Inhibitor, After Short-Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials

(2017) Frédéric Vanhoutte et al.   Arthritis & Rheumatology

Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism

(2017) Yuchen Nan et al.   Frontiers in Immunology

Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitative and quantitative techniques

(2016) Philip G Conaghan et al.   ANNALS OF THE RHEUMATIC DISEASES

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation

(2016) Douglas S Jones et al.   Nature Chemical Biology

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors

(2015) W Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

Type I IFNs as biomarkers in rheumatoid arthritis: towards disease profiling and personalized medicine

(2015) Javier Rodríguez-Carrio et al.   CLINICAL SCIENCE

The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation

(2015) Dan Lu et al.   NATURE IMMUNOLOGY

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice

(2015) Alba Llop-Guevara et al.   ARTHRITIS RESEARCH & THERAPY

Tofacitinib Facilitates the Expansion of Myeloid-Derived Suppressor Cells and Ameliorates Arthritis in SKG Mice

(2015) Keisuke Nishimura et al.   Arthritis & Rheumatology

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

(2014) D L Boyle et al.   ANNALS OF THE RHEUMATIC DISEASES

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global Metabolite Profiling of Synovial Fluid for the Specific Diagnosis of Rheumatoid Arthritis from Other Inflammatory Arthritis

(2014) Sooah Kim et al.   PLoS One

Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy

(2014) Helen L. Wright et al.   RHEUMATOLOGY

Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study

(2013) Désirée van der Heijde et al.   ARTHRITIS AND RHEUMATISM

Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds

(2013) K. Migita et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-β Autocrine Signaling to Promote Monocyte Recruitment

(2013) Deepak Venkatesh et al.   IMMUNITY

Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases

(2013) L. Van Rompaey et al.   JOURNAL OF IMMUNOLOGY

Preclinical Models for Drug Selection in Myeloproliferative Neoplasms

(2013) Niccolò Bartalucci et al.   Current Hematologic Malignancy Reports

FDA approves tofacitinib for rheumatoid arthritis

(2012) K. Traynor   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

(2012) Timothy P. LaBranche et al.   ARTHRITIS AND RHEUMATISM

The interaction between CXCL10 and cytokines in chronic inflammatory arthritis

(2012) Eun Young Lee et al.   AUTOIMMUNITY REVIEWS

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon

(2011) Sanna Rosengren et al.   ANNALS OF THE RHEUMATIC DISEASES

The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells

(2011) Keisuke Maeshima et al.   ARTHRITIS AND RHEUMATISM

IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

(2011) T. Mori et al.   INTERNATIONAL IMMUNOLOGY

Influence of Janus Kinase Inhibition on Interleukin 6-mediated Induction of Acute-phase Serum Amyloid A in Rheumatoid Synovium

(2011) K. MIGITA et al.   JOURNAL OF RHEUMATOLOGY

CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes

(2011) Kiyoshi Migita et al.   ARTHRITIS RESEARCH & THERAPY

Association of the response to tumor necrosis factor antagonists with plasma type I interferon activity and interferon-β/α ratios in rheumatoid arthritis patients: A post hoc analysis of a predominantly Hispanic cohort

(2010) Clio P. Mavragani et al.   ARTHRITIS AND RHEUMATISM

Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050

(2010) J. S. Fridman et al.   JOURNAL OF IMMUNOLOGY

Reciprocal cross-talk between RANKL and interferon-γ–inducible protein 10 is responsible for bone-erosive experimental arthritis

(2008) Han Bok Kwak et al.   ARTHRITIS AND RHEUMATISM

Cytokine Signaling Modules in Inflammatory Responses

(2008) John J. O'Shea et al.   IMMUNITY

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY