Type IV Coupling Proteins as Potential Targets to Control the Dissemination of Antibiotic Resistance

The C-terminal tail of the yeast mitochondrial transcription factor Mtf1 coordinates template strand alignment, DNA scrunching and timely transition into elongation

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From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective

(2019) Gabriel Waksman   EMBO REPORTS

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Structural bases for F plasmid conjugation and F pilus biogenesis inEscherichia coli

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Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system

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Horizontal Gene Transfer and Its Association with Antibiotic Resistance in the Genus Aeromonas spp.

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Type IV secretion in Gram-negative and Gram-positive bacteria

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Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system

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A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel

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Conjugation inhibitors compete with palmitic acid for binding to the conjugative traffic ATPase TrwD, providing a mechanism to inhibit bacterial conjugation

(2018) Yolanda García-Cazorla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two pKM101-Encoded Proteins, the Pilus-Tip Protein TraC and Pep, Assemble on the Escherichia coli Cell Surface as Adhesins Required for Efficient Conjugative DNA Transfer

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Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

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Application of sewage sludge to agricultural soil increases the abundance of antibiotic resistance genes without altering the composition of prokaryotic communities

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The application of fresh and composted horse and chicken manure affects soil quality, microbial composition and antibiotic resistance

(2018) Julen Urra et al.   APPLIED SOIL ECOLOGY

Substrate translocation involves specific lysine residues of the central channel of the conjugative coupling protein TrwB

(2017) Delfina Larrea et al.   MOLECULAR GENETICS AND GENOMICS

Use of chimeric type IV secretion systems to define contributions of outer membrane subassemblies for contact-dependent translocation

(2017) Jay E. Gordon et al.   MOLECULAR MICROBIOLOGY

Annotation of plasmid genes

(2017) Christopher M. Thomas et al.   PLASMID

Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101

(2017) Bastien Casu et al.   Scientific Reports

Biofilm-Forming Clinical Staphylococcus Isolates Harbor Horizontal Transfer and Antibiotic Resistance Genes

(2017) Sandra Águila-Arcos et al.   Frontiers in Microbiology

DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens

(2017) Dolores L. Guzmán-Herrador et al.   Frontiers in Microbiology

The Obscure World of Integrative and Mobilizable Elements, Highly Widespread Elements that Pirate Bacterial Conjugative Systems

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Architecture of the type IV coupling protein complex of Legionella pneumophila

(2017) Mi-Jeong Kwak et al.   Nature Microbiology

Computational methods in drug discovery

(2016) Sumudu P Leelananda et al.   Beilstein Journal of Organic Chemistry

Chimeric Coupling Proteins Mediate Transfer of Heterologous Type IV Effectors through the Escherichia coli pKM101-Encoded Conjugation Machine

(2016) Neal Whitaker et al.   JOURNAL OF BACTERIOLOGY

Structural Analysis and Inhibition of TraE from the pKM101 Type IV Secretion System

(2016) Bastien Casu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation

(2016) Jorge Ripoll-Rozada et al.   MOLECULAR MICROBIOLOGY

Tanzawaic Acids, a Chemically Novel Set of Bacterial Conjugation Inhibitors

(2016) María Getino et al.   PLoS One

The acidic C-terminus of vaccinia virus I3 single-strand binding protein promotes proper assembly of DNA–protein complexes

(2016) Melissa L. Harrison et al.   VIROLOGY

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens

(2016) Carrie L. Shaffer et al.   mBio

Integrative and Conjugative Elements (ICEs): What They Do and How They Work

(2015) Christopher M. Johnson et al.   Annual Review of Genetics

Role of GxxxG Motifs in Transmembrane Domain Interactions

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The All-Alpha Domains of Coupling Proteins from the Agrobacterium tumefaciens VirB/VirD4 and Enterococcus faecalis pCF10-Encoded Type IV Secretion Systems Confer Specificity to Binding of Cognate DNA Substrates

(2015) Neal Whitaker et al.   JOURNAL OF BACTERIOLOGY

Synthetic Fatty Acids Prevent Plasmid-Mediated Horizontal Gene Transfer

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2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

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Structure of a type IV secretion system

(2014) Harry H. Low et al.   NATURE

The transmembrane domain of the T4SS coupling protein TrwB and its role in protein–protein interactions

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Subcellular location of the coupling protein TrwB and the role of its transmembrane domain

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DNA Substrate-Induced Activation of the Agrobacterium VirB/VirD4 Type IV Secretion System

(2013) E. Cascales et al.   JOURNAL OF BACTERIOLOGY

Functional Interactions of VirB11 Traffic ATPases with VirB4 and VirD4 Molecular Motors in Type IV Secretion Systems

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The expanding bacterial type IV secretion lexicon

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Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors

(2012) Mark A. Smith et al.   CHEMISTRY & BIOLOGY

Bacterial Type IV secretion systems: versatile virulence machines

(2012) Daniel E Voth et al.   Future Microbiology

The Hexameric Structure of a Conjugative VirB4 Protein ATPase Provides New Insights for a Functional and Phylogenetic Relationship with DNA Translocases

(2012) Alejandro Peña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Conjugation and Type IV Secretion Systems

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Assembly and mechanisms of bacterial type IV secretion machines

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General requirements for protein secretion by the F-like conjugation system R1

(2012) Silvia Lang et al.   PLASMID

Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system

(2012) K. Wallden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Legionella IcmSW Complex Directly Interacts with DotL to Mediate Translocation of Adaptor-Dependent Substrates

(2012) Molly C. Sutherland et al.   PLoS Pathogens

Membrane insertion stabilizes the structure of TrwB, the R388 conjugative plasmid coupling protein

(2011) Ana J. Vecino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Functional Dissection of the Conjugative Coupling Protein TrwB

(2010) H. D. de Paz et al.   JOURNAL OF BACTERIOLOGY

The Conjugative DNA Translocase TrwB Is a Structure-specific DNA-binding Protein

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Mobility of Plasmids

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The global need for effective antibiotics: challenges and recent advances

(2010) Liselotte Diaz Högberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Plasmid R1 Conjugative DNA Processing Is Regulated at the Coupling Protein Interface

(2009) S. Mihajlovic et al.   JOURNAL OF BACTERIOLOGY

The Putative Coupling Protein TcpA Interacts with Other pCW3-Encoded Proteins To Form an Essential Part of the Conjugation Complex

(2009) J. A. Steen et al.   JOURNAL OF BACTERIOLOGY

Biological Diversity of Prokaryotic Type IV Secretion Systems

(2009) C. E. Alvarez-Martinez et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Enterococcus faecalis PcfC, a Spatially Localized Substrate Receptor for Type IV Secretion of the pCF10 Transfer Intermediate

(2008) Y. Chen et al.   JOURNAL OF BACTERIOLOGY

The Evolution of Class 1 Integrons and the Rise of Antibiotic Resistance

(2008) M. Gillings et al.   JOURNAL OF BACTERIOLOGY

Structural basis of specific TraD-TraM recognition during F plasmid-mediated bacterial conjugation

(2008) Jun Lu et al.   MOLECULAR MICROBIOLOGY