Leishmania Immunity: Advancing Immunotherapy and Vaccine Development

Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response

(2020) Hervé Lecoeur et al.   Cell Reports

Combined in vitro IL-12 and IL-15 stimulation promotes cellular immune response in dogs with visceral leishmaniasis

(2020) Sidnei Ferro Costa et al.   PLoS Neglected Tropical Diseases

CD4+ T Cell-Dependent Macrophage Activation Modulates Sustained PS Exposure on Intracellular Amastigotes of Leishmania amazonensis

(2019) Joao Luiz Mendes Wanderley et al.   Frontiers in Cellular and Infection Microbiology

Intradermal Synthetic DNA Vaccination Generates Leishmania-Specific T Cells in the Skin and Protection against Leishmania major

(2019) Lumena Louis et al.   INFECTION AND IMMUNITY

Immunotherapy using anti-PD-1 and anti-PD-L1 in Leishmania amazonensis-infected BALB/c mice reduce parasite load

(2019) Alessandra M. da Fonseca-Martins et al.   Scientific Reports

A large-scale field randomized trial demonstrates safety and efficacy of the vaccine LetiFend® against canine leishmaniosis

(2018) Javier Fernández Cotrina et al.   VACCINE

HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis

(2018) Akil Hammami et al.   Scientific Reports

Randomized, controlled, double-blinded field trial to assess Leishmania vaccine effectiveness as immunotherapy for canine leishmaniosis

(2018) Angela Toepp et al.   VACCINE

Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin

(2018) Fatemeh Khadir et al.   PLoS Neglected Tropical Diseases

Atypical leishmaniasis: A global perspective with emphasis on the Indian subcontinent

(2018) Lovlesh Thakur et al.   PLoS Neglected Tropical Diseases

Leishmania tarentolae expressing CXCL-10 as an efficient immunotherapy approach against Leishmania major -infected BALB/c mice

(2017) H. Montakhab-Yeganeh et al.   PARASITE IMMUNOLOGY

Continual renewal and replication of persistentLeishmania majorparasites in concomitantly immune hosts

(2017) Michael A. Mandell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

(2017) Mohamed Osman et al.   PLoS Neglected Tropical Diseases

Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major

(2017) Audrey Romano et al.   PLoS Pathogens

A Vaccine Therapy for Canine Visceral Leishmaniasis Promoted Significant Improvement of Clinical and Immune Status with Reduction in Parasite Burden

(2017) Bruno Mendes Roatt et al.   Frontiers in Immunology

Leptin regulates Granzyme-A, PD-1 and CTLA-4 expression in T cell to control visceral leishmaniasis in BALB/c Mice

(2017) Alti Dayakar et al.   Scientific Reports

Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17–Neutrophil Response

(2016) Gustavo F. S. Quirino et al.   INFECTION AND IMMUNITY

Pharmacological inhibition of p110δ subunit of PI3K confers protection against experimental leishmaniasis

(2016) Forough Khadem et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Possibilities and challenges for developing a successful vaccine for leishmaniasis

(2016) Saumya Srivastava et al.   Parasites & Vectors

Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge

(2016) Lucilene Aparecida Resende et al.   PLoS One

Different Leishmania Species Drive Distinct Neutrophil Functions

(2016) Benjamin P. Hurrell et al.   TRENDS IN PARASITOLOGY

Recombinant Forms of Leishmania amazonensis Excreted/Secreted Promastigote Surface Antigen (PSA) Induce Protective Immune Responses in Dogs

(2016) Elodie Petitdidier et al.   PLoS Neglected Tropical Diseases

Use of Oral Miltefosine for Cutaneous Leishmaniasis in Canadian Soldiers Returning from Afghanistan

(2016) Yoav Keynan et al.   Canadian Journal of Infectious Diseases & Medical Microbiology

Interaction of Macrophage Antigen 1 and CD40 Ligand Leads to IL-12 Production and Resistance in CD40-Deficient Mice Infected withLeishmania major

(2015) Ifeoma Okwor et al.   JOURNAL OF IMMUNOLOGY

Identification of broadly conserved cross-species protective Leishmania antigen and its responding CD4 + T cells

(2015) Zhirong Mou et al.   Science Translational Medicine

Modulation of Dendritic Cell Function by Leishmania Parasites

(2014) L. Soong   JOURNAL OF IMMUNOLOGY

Interleukin 17A Acts Synergistically With Interferon γ to Promote Protection Against Leishmania infantum Infection

(2014) Manuela Sales Lima Nascimento et al.   JOURNAL OF INFECTIOUS DISEASES

In Vitro Evaluation of a Soluble Leishmania Promastigote Surface Antigen as a Potential Vaccine Candidate against Human Leishmaniasis

(2014) Rym Chamakh-Ayari et al.   PLoS One

Th1 Stimulatory Proteins of Leishmania donovani: Comparative Cellular and Protective Responses of rTriose Phosphate Isomerase, rProtein Disulfide Isomerase and rElongation Factor-2 in Combination with rHSP70 against Visceral Leishmaniasis

(2014) Anil Kumar Jaiswal et al.   PLoS One

NK Cell Activity Differs between Patients with Localized and Diffuse Cutaneous Leishmaniasis Infected with Leishmania mexicana: A Comparative Study of TLRs and Cytokines

(2014) Isabel Cristina Cañeda-Guzmán et al.   PLoS One

A systematic review of the efficacy of prophylactic control measures for naturally-occurring canine leishmaniosis, part I: Vaccinations

(2014) C.E. Wylie et al.   PREVENTIVE VETERINARY MEDICINE

CD8+ T cells Are Preferentially Activated during Primary Low Dose Leishmania major Infection but Are Completely Dispensable during Secondary Anti-Leishmania Immunity

(2014) Ifeoma B. Okwor et al.   PLoS Neglected Tropical Diseases

Impact of Leishmania mexicana Infection on Dendritic Cell Signaling and Functions

(2014) Irazú Contreras et al.   PLoS Neglected Tropical Diseases

IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection

(2013) Claudia Gonzalez-Lombana et al.   PLoS Pathogens

Performance of LBSap Vaccine after Intradermal Challenge with L. infantum and Saliva of Lu. longipalpis: Immunogenicity and Parasitological Evaluation

(2012) Bruno Mendes Roatt et al.   PLoS One

Use of a LiESP/QA-21 Vaccine (CaniLeish) Stimulates an Appropriate Th1-Dominated Cell-Mediated Immune Response in Dogs

(2012) Javier Moreno et al.   PLoS Neglected Tropical Diseases

Leishmania-Infected Macrophages Are Targets of NK Cell-Derived Cytokines but Not of NK Cell Cytotoxicity

(2011) Chittappen K. Prajeeth et al.   INFECTION AND IMMUNITY

IL-10 Neutralization Promotes Parasite Clearance in Splenic Aspirate Cells From Patients With Visceral Leishmaniasis

(2011) Shalini Gautam et al.   JOURNAL OF INFECTIOUS DISEASES

Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation

(2010) Eszter Deak et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LXR Deficiency Confers Increased Protection against Visceral Leishmania Infection in Mice

(2010) Kevin W. Bruhn et al.   PLoS Neglected Tropical Diseases

IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani

(2009) Maira G.R. Pitta et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection

(2009) F. O. Novais et al.   JOURNAL OF IMMUNOLOGY

A novel form of NF-κB is induced byLeishmaniainfection: Involvement in macrophage gene expression

(2008) David J. Gregory et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treatment of leishmaniasis with miltefosine: 2008 status

(2008) Jonathan (Josh) Berman   Expert Opinion on Drug Metabolism & Toxicology

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE