Article
Nutrition & Dietetics
Helena Tiekou Lorinczova, Gulshanara Begum, Derek Renshaw, Mohammed Gulrez Zariwala
Summary: This study aimed to evaluate the influence of a formulated bioavailable form of curcumin on acute iron absorption and status, and the results showed that the formulated curcumin did not negatively impact acute iron absorption in healthy humans, regardless of the dose used.
Article
Nutrition & Dietetics
Helena Tiekou Lorinczova, Gulshanara Begum, Lina Temouri, Derek Renshaw, Mohammed Gulrez Zariwala
Summary: The aim of this study was to evaluate whether co-administration of ferrous sulphate and formulated curcumin could reduce systemic inflammation and gastrointestinal side-effects. The results showed that the combination of ferrous sulphate and curcumin can reduce inflammation-related markers in the plasma. This supplementation approach may be a more cost-effective and convenient alternative to current oral iron-related treatments, but further research is needed.
Article
Nutrition & Dietetics
Shasta McMillen, Bo Lonnerdal
Summary: Iron supplementation in rat pups significantly increased body iron stores without affecting CNS mineral interactions, iron regulation, or myelination, suggesting that the source of iron may influence brain size. Further studies are needed to investigate the effects of different forms of iron on neurodevelopment in order to optimize iron recommendations for all infants.
Article
Biochemistry & Molecular Biology
Marina Friling, Ana Maria Garcia-Munoz, Tania Perrinjaquet-Moccetti, Desiree Victoria-Montesinos, Silvia Perez-Pinero, Maria Salud Abellan-Ruiz, Antonio J. Luque-Rubia, Ana Isabel Garcia-Guillen, Fernando Canovas, Eran Ivanir
Summary: This study compared the tolerability of oral supplementation with AB-Fortis (R) and conventional ferrous sulfate (FS) in healthy premenopausal women, and found that AB-Fortis (R) had significantly better tolerability than FS. The better tolerability of AB-Fortis (R) was further confirmed when compared to a real-life setting. Overall, the administration of both study products was safe with no serious or significant adverse events reported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Xiya Zhao, Xu Zhang, Teng Xu, Junjie Luo, Yongting Luo, Peng An
Summary: Lactoferrin supplementation has superior effects on serum iron, ferritin, and hemoglobin concentration compared to ferrous sulfate. However, it has a reducing effect on fractional iron absorption and IL-6 levels.
Review
Food Science & Technology
Lara Gomes Suhett, Rodrigo de Miranda Monteiro Santos, Brenda Kelly Souza Silveira, Arieta Carla Gualandi Leal, Alice Divina Melo de Brito, Juliana Farias de Novaes, Ceres Mattos Della Lucia
Summary: Curcumin, the main phenolic compound in turmeric, has been found to have positive effects on athletes and physical exercise practitioners, showing benefits such as reduced inflammation and oxidative stress, decreased pain and muscle damage, superior recovery and muscle performance, improved psychological and physiological responses, and enhanced gastrointestinal function.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Isabella Cristina de Castro Lippi, Fabiana Ribeiro Caldara, Ibiara Correia de Lima Almeida-Paz, Henrique Biasotto Morais, Agnes Markiy Odakura, Elisabete Castelon Konkiewitz, Welber Sanches Ferreira, Thiago Leite Fraga, Maria Fernanda de Castro Burbarelli, Gisele Aparecida Felix, Rodrigo Garofallo Garcia, Luan Sousa dos Santos
Summary: Environmental enrichment using music therapy can improve animal welfare, specifically in sows and their piglets. Music therapy helps to remove the sterility of the breeding environment and enhance the productive performance and neuroplasticity of the piglets.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Review
Medicine, General & Internal
Michal Piotrkowicz, Marlena Janoska-Jazdzik, Tytus Koweszko, Agata Szulc
Summary: Psychotherapy has been shown to lead to changes in brain structure and function, with BDNF identified as a potential research target. Limited studies indicate that BDNF concentration levels may increase after psychotherapy, but the impact of BDNF gene methylation status remains to be explored.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
He You, Bai Lu
Summary: In this manuscript, a comprehensive overview of the molecular regulation and structural characteristics of Bdnf promoters is presented, along with a summary of the current knowledge on the cellular and physiological functions of distinct Bdnf transcripts. The roles of Bdnf transcripts in psychiatric disorders, cognitive functions, and metabolism are discussed. Future research directions are proposed to enhance our understanding of the complex functions of Bdnf and its diverse promoters.
Article
Nutrition & Dietetics
Katia Urso, Javier Leal Martinez-Bujanda, Jaime Moscoso del Prado
Summary: This study compared the efficacy of ferrous sulphate (FeSO4) and iron protein succinylate (Ferplex) in the treatment of iron deficiency anemia (IDA). Results showed that both types of iron supplementation were equally effective in restoring anemia-related parameters within 15 days, with improvements in body weight and platelet levels. The study demonstrated that lower and higher doses of iron were equally effective, supporting the idea that lower therapeutic doses are sufficient for managing IDA.
Article
Nutrition & Dietetics
Shasta McMillen, Sydney Thomas, Emily Liang, Eric B. Nonnecke, Carolyn Slupsky, Bo Lonnerdal
Summary: The gut microbiota is implicated in the adverse developmental outcomes of postnatal iron supplementation, and the form of iron can influence microbiota diversity and metabolite changes. Early iron provision can have long-term effects on the gut microbiota and microbial metabolism in adult rats.
Review
Biochemistry & Molecular Biology
David Gustafsson, Andrea Klang, Sebastian Thams, Elham Rostami
Summary: BDNF plays a crucial role in neural repair and regeneration, making it a focus of TBI research. Studies have shown varied effects on BDNF expression based on different experimental setups and interventions. Clinical research emphasizes the significance of BDNF polymorphism in outcomes, highlighting its protective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lih-Geeng Chen, Ching-Chiung Wang, Yi-Shan Lee, Yi-Yan Sie, Chi- Chang, Wen-Chi Hou
Summary: Resveratrol tetramers of hopeaphenol, vitisin A, and vitisin B show potential in improving degenerative disorders.
Review
Neurosciences
Sara Abdolahi, Ameneh Zare-Chahoki, Farshid Noorbakhsh, Ali Gorji
Summary: The interactions between neurotrophins and miRNAs play a crucial role in neuropsychological disorders, and hold potential as diagnostic and therapeutic strategies. Future clinical studies are needed to validate the potential of targeting neurotrophin-miRNA interactions.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Corbin Griffen, Michael Duncan, John Hattersley, Martin O. Weickert, Alexander Dallaway, Derek Renshaw
Summary: The study showed that 12 weeks of resistance exercise and whey protein supplementation in older men can increase muscle strength, mass, physical function, and reduce inflammation. Whey protein supplementation alone can improve walking speed. No synergistic effects were observed.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Nutrition & Dietetics
Helena Tiekou Lorinczova, Gulshanara Begum, Lina Temouri, Derek Renshaw, Mohammed Gulrez Zariwala
Summary: The aim of this study was to evaluate whether co-administration of ferrous sulphate and formulated curcumin could reduce systemic inflammation and gastrointestinal side-effects. The results showed that the combination of ferrous sulphate and curcumin can reduce inflammation-related markers in the plasma. This supplementation approach may be a more cost-effective and convenient alternative to current oral iron-related treatments, but further research is needed.
Article
Nutrition & Dietetics
Sehar Sajid, Mohammed Gulrez Zariwala, Richard Mackenzie, Mark Turner, Theo Nell, Srikanth Bellary, Derek Renshaw
Summary: Obesity is associated with an increased risk of developing metabolic syndrome and comorbidities. The dysregulated expansion of adipose tissue during obesity leads to the development of low-grade chronic inflammation. Annexin A1 may play a protective role in obesity and inflammation, but its effect may be overshadowed by the systemic inflammation caused by obesity.
Article
Pharmacology & Pharmacy
Hisham Al-Obaidi, Ieva Petraityte, Thomas Hibbard, Mridul Majumder, Rachith Kalgudi, Mohammed Gulrez Zariwala
Summary: This study presents a novel approach to enhance the penetration and antifungal activity of the antifungal drug griseofulvin. The prepared nanosuspensions significantly suppressed fungal activity and showed improved solubility of the drug. The type of surfactant and milling conditions had varied effects on permeability and particle size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Physiology
Mark C. Turner, Ryan Brett, Amarjit Saini, Claire E. Stewart, Derek Renshaw
Summary: The concentration of serum affects the differentiation of LHCN-M2 skeletal muscle cells, but does not have a significant impact on mitochondrial function. The findings suggest that LHCN-M2 myoblast cell line can be used to study skeletal muscle development and metabolism.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leah Mursaleen, Stefanie Ho Yi Chan, Brendon Noble, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala
Summary: This study investigates the potential of nanocarrier delivery systems, specifically Pluronic(R) F68 (P68) and dequalinium (DQA) nanocarriers, to enhance the brain penetration and targeted delivery of curcumin, N-acetylcysteine (NAC), and/or deferoxamine (DFO). The results show that P68 + DQA nanocarriers significantly increase the passage of curcumin, NAC, and DFO across the blood-brain barrier (BBB) model. These nanocarriers also improve the protective effects of curcumin, NAC, and/or DFO against rotenone-induced toxicity and oxidative stress by targeting mitochondria. This study highlights the potential effectiveness of this nanocarrier strategy in utilizing the therapeutic benefits of these antioxidants.
Article
Sport Sciences
Freddy Brown, Mathew Hill, Derek Renshaw, Charles Pedlar, Jessica Hill, Jason Tallis
Summary: This study assessed the reliability of garment interface pressure measurements and lower-limb maximal voluntary contraction forces in non-resistance-trained males. The results showed that strength declined between days in consecutive testing, while cycling peak power increased. These findings highlight the importance of considering strength losses resulting from performance tests when assessing recovery.
SPORTS ENGINEERING
(2023)
Article
Chemistry, Applied
Stefanie Ho Yi Chan, Khalid Sheikh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu
Summary: This study aims to develop dry powder formulations of azithromycin-loaded PLGA nanocomposite microparticles for pulmonary delivery to improve its low bioavailability. The addition of chitosan changed the neutral azithromycin formulation to positively-charged nanoparticles, but also increased the particle size. The dry powder formulations were able to deliver azithromycin to the deep lung regions, demonstrating the potential of using pulmonary drug delivery as an effective method to treat COVID-19.
JOURNAL OF MICROENCAPSULATION
(2023)
Article
Medicine, General & Internal
Alexander Dallaway, Michael Duncan, Corbin Griffen, Jason Tallis, Derek Renshaw, John Hattersley
Summary: This study investigated age-related differences in trunk kinematics during walking in healthy men. Secondary aims were to investigate the covarying effects of physical activity (PA) and lumbar paravertebral muscle (LPM) morphology on trunk kinematics, and the effect of age on interplanar coupling between the trunk and pelvis. The results showed phase-specific differences in the coronal and transverse planes, with midstance and swing phases highlighted as instances when trunk and pelvic kinematics differed significantly between the younger group and older group. Controlling for age, fewer significant positive correlations were revealed between trunk and pelvic ranges and planes of motion. LPM morphology and PA were not significant covariates of age-related differences in trunk kinematics. Age-related differences in trunk kinematics were most apparent in the coronal and transverse planes. The results further indicate ageing causes an uncoupling of interplanar upper body movements during gait. These findings provide important information for rehabilitation programmes in older adults designed to improve trunk motion, as well as enable identification of higher-risk movement patterns related to falling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Freddy Brown, Matt Hill, Derek Renshaw, Charles Pedlar, Jessica Hill, Ken van Someren, Glyn Howatson, Jason Tallis
Summary: This study investigated the effects of compression garments on recovery from exercise-induced muscle damage and the repeated bout effect. The results showed that compression garments did not enhance recovery but impaired the repeated bout effect at higher isokinetic velocities.
EXPERIMENTAL PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Holly N. N. Brown, Thomas Barber, Derek Renshaw, Sebastien Farnaud, Dominic Oduro-Donkor, Mark C. C. Turner
Summary: The gut microbiome plays a key role in maintaining host health and wellbeing, and its dysregulation is associated with chronic diseases such as obesity. It is hypothesized that the gut microbiome contributes to obesity through various pathways, including food digestion, energy metabolism, and intestinal barrier function. Additionally, the gut microbiome may also influence the metabolic, inflammatory, and satiety benefits of bariatric procedures like sleeve gastrectomy. Further research is needed to address limitations such as small sample size, methodological variability, and lack of associative data in order to better understand the potential of the gut microbiome in optimizing post-surgery outcomes.
Article
Psychiatry
Hayley Crawford, Chris Oliver, Laura Groves, Louise Bradley, Kayla Smith, Abigail Hogan, Derek Renshaw, Jane Waite, Jane Roberts
Summary: Anxiety is particularly heightened in individuals with intellectual disability, especially those with specific neurogenetic syndromes. However, assessing anxiety in these individuals is challenging due to a lack of appropriate measures that account for communication impairment and co-occurring conditions. This study uses a multi-method approach to identify behavioral and physiological indicators of anxiety in individuals with fragile X and Cornelia de Lange syndromes, comparing them to neurotypical children. The results highlight the prominent behavioral indicators of anxiety, such as physical avoidance and proximity seeking, as well as the pervasive physiological arousal in these neurogenetic groups. Autism was found to be associated with anxiety in the fragile X group but not in the Cornelia de Lange group, suggesting syndrome-specific nuances in the relationship between anxiety and autism.
PSYCHIATRY RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Lucy Petagine, Mohammed Gulrez Zariwala, Vinood B. Patel
Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant global disease burden and a leading cause of mortality. The precise triggers for disease progression and the propagation to cirrhosis are still not fully understood. Treatment options have been explored, but an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical utility.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
