Saponin Formosanin C-induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

(2020) Ross A. Weber et al.   MOLECULAR CELL

ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis

(2020) Junru Chen et al.   Oncogenesis

Dietary phytochemicals with anti-oxidant and pro-oxidant activities: A double-edged sword in relation to adjuvant chemotherapy and radiotherapy?

(2019) Wasundara Fernando et al.   CANCER LETTERS

p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine

(2018) Jelena Krstic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

(2018) Gaofei Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Autophagy mediates cytotoxicity of human colorectal cancer cells treated with garcinielliptone FC

(2017) Shen-Jeu Won et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

(2017) Shumei Ma et al.   PLoS One

Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis

(2017) Xiao-Jie Sun et al.   MEDICAL SCIENCE MONITOR

Iron and cancer: recent insights

(2016) David H. Manz et al.   Annals of the New York Academy of Sciences

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells

(2016) Jing Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mechanisms of Selective Autophagy in Normal Physiology and Cancer

(2016) Joseph D. Mancias et al.   JOURNAL OF MOLECULAR BIOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

(2015) Yu-Jie Zhang et al.   MOLECULES

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Paris saponin II inhibits human ovarian cancer cell-induced angiogenesis by modulating NF-κB signaling

(2015) MEI YANG et al.   ONCOLOGY REPORTS

ACSL4 promotes prostate cancer growth, invasion and hormonal resistance

(2015) Xinyu Wu et al.   Oncotarget

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Ras-Related Tumorigenesis Is Suppressed by BNIP3-Mediated Autophagy through Inhibition of Cell Proliferation

(2015) Shan-Ying Wu et al.   NEOPLASIA

The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling

(2014) Yuanyuan Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Justicidin A-Induced Autophagy Flux Enhances Apoptosis of Human Colorectal Cancer Cells via Class III PI3K and Atg5 Pathway

(2014) Shen-Jeu Won et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Why should autophagic flux be assessed?

(2013) Xiao-jie Zhang et al.   ACTA PHARMACOLOGICA SINICA

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Curcumin-Induced Mitotic Spindle Defect and Cell Cycle Arrest in Human Bladder Cancer Cells Occurs Partly through Inhibition of Aurora A

(2011) H.-S. Liu et al.   MOLECULAR PHARMACOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential

(2008) Jenq-Chang Lee et al.   CANCER SCIENCE

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Phloroglucinols with Prooxidant Activity fromGarcinia subelliptica

(2008) Chien-Chang Wu et al.   JOURNAL OF NATURAL PRODUCTS