Rapid Evaluation of Antibody Fragment Endocytosis for Antibody Fragment–Drug Conjugates

Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension

(2019) Qing Li et al.   BIOCONJUGATE CHEMISTRY

Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes

(2019) Anne Ljungars et al.   Frontiers in Pharmacology

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

(2018) Łukasz Opaliński et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fate of Antibody-Drug Conjugates in Cancer Cells

(2018) Cécile Chalouni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer

(2018) Babak Nami et al.   Cancers

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

(2017) Łukasz Opaliński et al.   Scientific Reports

Specific Conjugation of the Hinge Region for Homogeneous Preparation of Antibody Fragment-Drug Conjugate: A Case Study for Doxorubicin-PEG-anti-CD20 Fab′ Synthesis

(2016) Zhan Zhou et al.   BIOCONJUGATE CHEMISTRY

The tumor-inhibitory effectiveness of a novel anti-Trop2 Fab conjugate in pancreatic cancer

(2016) Yuan Mao et al.   Oncotarget

Targeting membrane proteins for antibody discovery using phage display

(2016) Martina L. Jones et al.   Scientific Reports

Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics

(2015) Eunhee G. Kim et al.   Biomolecules & Therapeutics

Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes

(2015) Paul R Moody et al.   MOLECULAR THERAPY

Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results

(2015) Emily Mason-Osann et al.   Scientific Reports

Precise Quantification of Nanoparticle Internalization

(2013) Claudia Gottstein et al.   ACS Nano

Anti-hepatoma human single-chain Fv antibody and adriamycin conjugates with potent antitumor activity

(2013) Lin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells

(2013) M. G. Terp et al.   JOURNAL OF IMMUNOLOGY

Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates

(2013) Michael Ritchie et al.   mAbs

A confocal microscopy image analysis method to measure adhesion and internalization of Pseudomonas aeruginosa multicellular structures into epithelial cells

(2013) Paola Lepanto et al.   MOLECULAR AND CELLULAR PROBES

Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy

(2013) Gwendlyn Kollmorgen et al.   Molecular Oncology

A Human Anti-c-Met Fab Fragment Conjugated with Doxorubicin as Targeted Chemotherapy for Hepatocellular Carcinoma

(2013) Ximin Chen et al.   PLoS One

Bispecific small molecule-antibody conjugate targeting prostate cancer

(2013) C. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

(2011) S. I. Rudnick et al.   CANCER RESEARCH

Structural and Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody

(2011) Li Peng et al.   JOURNAL OF MOLECULAR BIOLOGY

Porcine Sialoadhesin (CD169/Siglec-1) Is an Endocytic Receptor that Allows Targeted Delivery of Toxins and Antigens to Macrophages

(2011) Peter L. Delputte et al.   PLoS One

Internalizing Cancer Antibodies from Phage Libraries Selected on Tumor Cells and Yeast-Displayed Tumor Antigens

(2010) Yu Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

Certolizumab Pegol

(2010) Niti Goel et al.   mAbs

Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments

(2010) Meghan L. Marre et al.   PLoS One

Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC

(2010) Akito Natsume   Drug Design Development and Therapy

Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability

(2008) Michael M. Schmidt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anti-CD30 diabody-drug conjugates with potent antitumor activity

(2008) K. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS