The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

Review: Current and new generation pneumococcal vaccines

(2014) Charles Feldman et al.   JOURNAL OF INFECTION

Human Monocyte Recognition of Adenosine-Based Cyclic Dinucleotides Unveils the A2a GαsProtein-Coupled Receptor Tonic Inhibition of Mitochondrially Induced Cell Death

(2014) Marie Tosolini et al.   MOLECULAR AND CELLULAR BIOLOGY

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness

(2014) Marco Lolicato et al.   Nature Chemical Biology

Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice

(2014) Ivana Škrnjug et al.   PLoS One

IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection

(2013) Derek A. Pociask et al.   AMERICAN JOURNAL OF PATHOLOGY

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Airway epithelial regulation of pulmonary immune homeostasis and inflammation

(2013) Teal S. Hallstrand et al.   CLINICAL IMMUNOLOGY

Species-specific detection of the antiviral small-molecule compound CMA by STING

(2013) Taner Cavlar et al.   EMBO JOURNAL

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome

(2013) Ali A Abdul-Sater et al.   EMBO REPORTS

STING/MPYS Mediates Host Defense against Listeria monocytogenes Infection by Regulating Ly6Chi Monocyte Migration

(2013) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

MPYS/STING-Mediated TNF- , Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3'-5')-Cyclic-Di-Guanosine-Monophosphate In Vivo

(2013) S. M. Blaauboer et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

(2013) Guanghui Yi et al.   PLoS One

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities

(2012) Peter M. Gray et al.   CELLULAR IMMUNOLOGY

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

(2012) Songying Ouyang et al.   IMMUNITY

Interleukin-22 Is Produced by Invariant Natural Killer T Lymphocytes during Influenza A Virus Infection

(2012) Christophe Paget et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

(2012) Qian Yin et al.   MOLECULAR CELL

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

(2012) Chang Shu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

(2012) Guijun Shang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Identification and characterization of a loss-of-function human MPYS variant

(2011) L Jin et al.   GENES AND IMMUNITY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

(2011) Thomas Ebensen et al.   VACCINE

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

(2010) Wangxue Chen et al.   VACCINE

3′,5′-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection

(2009) Hongbin Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection

(2009) Dong-Liang Hu et al.   VACCINE

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection

(2008) Abiodun D. Ogunniyi et al.   VACCINE