Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia

MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders

(2020) Dong Han et al.   Frontiers in Pharmacology

MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles

(2020) Iñaki Osorio-Querejeta et al.   Pharmaceutics

Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury

(2020) Xiaobing Long et al.   Journal of Neuroinflammation

MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease

(2019) Longping Yao et al.   FASEB JOURNAL

Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice

(2019) Ke Liao et al.   Journal of Neuroimmune Pharmacology

Cocaine Induces Inflammatory Gut Milieu by Compromising the Mucosal Barrier Integrity and Altering the Gut Microbiota Colonization

(2019) Ernest T. Chivero et al.   Scientific Reports

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

(2019) Liuwan Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats

(2019) Raghubendra Singh Dagur et al.   Journal of Extracellular Vesicles

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson’s disease

(2018) Longping Yao et al.   Journal of Neuroinflammation

Astrocyte EV-induced lincRNA-Cox2 regulates microglial phagocytosis: Implications for morphine-mediated potentiation of neurodegeneration

(2018) Guoku Hu et al.   Molecular Therapy-Nucleic Acids

The Neuroprotective Role of MiR-124-3p in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5

(2017) Rui-Fang Dong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

(2017) David Rufino-Ramos et al.   JOURNAL OF CONTROLLED RELEASE

Screening the expression characteristics of several miRNAs in G93A-SOD1 transgenic mouse: altered expression of miRNA-124 is associated with astrocyte differentiation by targeting Sox2 and Sox9

(2017) Fenghua Zhou et al.   JOURNAL OF NEUROCHEMISTRY

HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation

(2017) Ernest T. Chivero et al.   JOURNAL OF NEUROSCIENCE

Cocaine-Mediated Downregulation of miR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling

(2017) Palsamy Periyasamy et al.   MOLECULAR NEUROBIOLOGY

Cell-to-cell communication: microRNAs as hormones

(2017) Recep Bayraktar et al.   Molecular Oncology

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10

(2016) Fernanda Pedrotti Moreira et al.   DRUG AND ALCOHOL DEPENDENCE

Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation

(2016) Ming-Lei Guo et al.   Epigenetics

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis

(2016) Ke Liao et al.   Journal of Neuroinflammation

Plasma interleukin-6 and executive function in crack cocaine-dependent women

(2016) Mateus Luz Levandowski et al.   NEUROSCIENCE LETTERS

Cocaine-mediated microglial activation involves the ER stress-autophagy axis

(2015) Ming-Lei Guo et al.   Autophagy

MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim

(2015) Huiqing Wang et al.   BRAIN PATHOLOGY

miR-124Contributes to the functional maturity of microglia

(2015) Adam J. Svahn et al.   Developmental Neurobiology

Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment

(2015) Patrice Penfornis et al.   INTERNATIONAL JOURNAL OF CANCER

Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins

(2014) N. Kanagaraj et al.   NEUROSCIENCE

Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

(2014) Mario Leonardo Squadrito et al.   Cell Reports

Aberrant Disgust Responses and Immune Reactivity in Cocaine-Dependent Men

(2013) Karen D. Ersche et al.   BIOLOGICAL PSYCHIATRY

IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and during Allergic Inflammation

(2013) Tatyana Veremeyko et al.   PLoS One

Data Available on the Extent of Cocaine Use and Dependence: Biochemistry, Pharmacologic Effects and Global Burden of Disease of Cocaine Abusers

(2012) C. Pomara et al.   CURRENT MEDICINAL CHEMISTRY

Immune system inflammation in cocaine dependent individuals: implications for medications development

(2012) Helen C. Fox et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Psychostimulant Abuse and Neuroinflammation: Emerging Evidence of Their Interconnection

(2012) Kenneth H. Clark et al.   NEUROTOXICITY RESEARCH

Intranasal drug delivery: An efficient and non-invasive route for systemic administration

(2012) Stanislas Grassin-Delyle et al.   PHARMACOLOGY & THERAPEUTICS

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Induction of innate immune genes in brain create the neurobiology of addiction

(2011) F.T. Crews et al.   BRAIN BEHAVIOR AND IMMUNITY

Intranasal Exosomes for Treatment of Neuroinflammation?: Prospects and Limitations

(2011) Samira Lakhal et al.   MOLECULAR THERAPY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease

(2011) Marong Fang et al.   TOXICOLOGY LETTERS

In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs

(2010) Pascal Smith et al.   JOURNAL OF NEUROCHEMISTRY

Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment

(2010) Sang-Soo Kim et al.   MOLECULAR THERAPY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Gene Dysregulation in Huntington’s Disease: REST, MicroRNAs and Beyond

(2009) Rory Johnson et al.   NEUROMOLECULAR MEDICINE