Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells

Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches

(2020) Jean-Francois Poulin et al.   TRENDS IN NEUROSCIENCES

Preparing for first human trial of induced pluripotent stem cell-derived cells for Parkinson's disease: an interview with Jun Takahashi

(2019) Jun Takahasi   Regenerative Medicine

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

(2019) Katarína Tiklová et al.   Nature Communications

Single-cell metabolomics by mass spectrometry: Advances, challenges, and future applications

(2019) Ahmed Ali et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution

(2019) Samuel G. Rodriques et al.   SCIENCE

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

(2019) Chee-Huat Linus Eng et al.   NATURE

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

(2019) Leif S. Ludwig et al.   CELL

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

(2019) Jin Xu et al.   eLife

Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease

(2019) Roger A. Barker et al.   NATURE MEDICINE

CUT&Tag for efficient epigenomic profiling of small samples and single cells

(2019) Hatice S. Kaya-Okur et al.   Nature Communications

Multiplexed detection of RNA using MERFISH and branched DNA amplification

(2019) Chenglong Xia et al.   Scientific Reports

Sci-Hi-C: A single-cell Hi-C method for mapping 3D genome organization in large number of single cells

(2019) Vijay Ramani et al.   METHODS

High-definition spatial transcriptomics for in situ tissue profiling

(2019) Sanja Vickovic et al.   NATURE METHODS

Optical Pooled Screens in Human Cells

(2019) David Feldman et al.   CELL

Overlapping genetic architecture between Parkinson disease and melanoma

(2019) Umber Dube et al.   ACTA NEUROPATHOLOGICA

Deep Profiling of Cellular Heterogeneity by Emerging Single‐Cell Proteomic Technologies

(2019) Liwei Yang et al.   PROTEOMICS

Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease

(2018) Paul W. Hook et al.   AMERICAN JOURNAL OF HUMAN GENETICS

bHLH transcription factors in neural development, disease, and reprogramming

(2018) Daniel J. Dennis et al.   BRAIN RESEARCH

Single-Cell Transcriptomics Meets Lineage Tracing

(2018) Lennart Kester et al.   Cell Stem Cell

Exponential scaling of single-cell RNA-seq in the past decade

(2018) Valentine Svensson et al.   Nature Protocols

Pluripotent stem cell-based therapy for Parkinson’s disease: Current status and future prospects

(2018) Kai-C. Sonntag et al.   PROGRESS IN NEUROBIOLOGY

Three-dimensional intact-tissue sequencing of single-cell transcriptional states

(2018) Xiao Wang et al.   SCIENCE

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

(2018) Jean-Francois Poulin et al.   NATURE NEUROSCIENCE

Spatial organization of the somatosensory cortex revealed by osmFISH

(2018) Simone Codeluppi et al.   NATURE METHODS

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

(2017) Blue B Lake et al.   NATURE BIOTECHNOLOGY

Pooled CRISPR screening with single-cell transcriptome readout

(2017) Paul Datlinger et al.   NATURE METHODS

Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

(2017) Sara Nolbrant et al.   Nature Protocols

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets

(2017) Marten P. Smidt   Frontiers in Neuroanatomy

Neuronal Subset-Specific Migration and Axonal Wiring Mechanisms in the Developing Midbrain Dopamine System

(2017) Sara Brignani et al.   Frontiers in Neuroanatomy

Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons

(2017) Joseph D. Dougherty   Scientific Reports

Replacing Dopamine Neurons in Parkinson’s Disease: How did it happen?

(2017) Anders Björklund et al.   Journal of Parkinsons Disease

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

(2017) Daniela Lehnen et al.   Stem Cell Reports

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

(2016) Diego Adhemar Jaitin et al.   CELL

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease

(2016) J Carlos Villaescusa et al.   EMBO JOURNAL

Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons

(2016) Panojot Bifsha et al.   MOLECULAR NEUROBIOLOGY

Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling

(2016) Susanne Nichterwitz et al.   Nature Communications

Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1

(2016) Bumpei Samata et al.   Nature Communications

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents

(2016) Jonathan C. Niclis et al.   Stem Cells Translational Medicine

Midbrain dopamine neurons in Parkinson׳s disease exhibit a dysregulated miRNA and target-gene network

(2015) Christine E. Briggs et al.   BRAIN RESEARCH

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

(2015) Jop Kind et al.   CELL

How to make a midbrain dopaminergic neuron

(2015) E. Arenas et al.   DEVELOPMENT

Establishing diversity in the dopaminergic system

(2015) Gabriela O. Bodea et al.   FEBS LETTERS

Clinical translation of stem cell transplantation in Parkinson's disease

(2015) O. Lindvall   JOURNAL OF INTERNAL MEDICINE

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state

(2015) Assaf Rotem et al.   NATURE BIOTECHNOLOGY

Cell-based therapies for Parkinson disease—past insights and future potential

(2015) Roger A. Barker et al.   Nature Reviews Neurology

Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors

(2015) Chris R. Bye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons

(2015) J.-I. Kim et al.   SCIENCE

Genetic control of midbrain dopaminergic neuron development

(2015) Sandra Blaess et al.   Wiley Interdisciplinary Reviews-Developmental Biology

WNT signaling in midbrain dopaminergic neuron development and cell replacement therapies for Parkinson’s disease

(2015) Ernest Arenas et al.   SpringerPlus

Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis

(2014) B. Artegiani et al.   EMBO JOURNAL

Highly Multiplexed Subcellular RNA Sequencing in Situ

(2014) J. H. Lee et al.   SCIENCE

Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons

(2014) Lia Panman et al.   Cell Reports

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra

(2014) Panojot Bifsha et al.   PLoS Genetics

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

(2014) Daisuke Doi et al.   Stem Cell Reports

Morphogen interpretation: the transcriptional logic of neural tube patterning

(2013) Michael Cohen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development

(2013) J. Yang et al.   DEVELOPMENT

Specification of dopaminergic subsets involves interplay of En1 and Pitx3

(2013) J. V. Veenvliet et al.   DEVELOPMENT

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

(2013) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species

(2013) A. D. Workman et al.   JOURNAL OF NEUROSCIENCE

In situ sequencing for RNA analysis in preserved tissue and cells

(2013) Rongqin Ke et al.   NATURE METHODS

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

(2013) E. R. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detailed Expression Analysis of Regulatory Genes in the Early Developing Human Neural Tube

(2013) Ulrika Marklund et al.   STEM CELLS AND DEVELOPMENT

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

(2013) Lars Brichta et al.   TRENDS IN NEUROSCIENCES

Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease

(2013) Zinovia Kefalopoulou et al.   JAMA Neurology

Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans

(2012) Leonie C. Jacobs et al.   HUMAN GENETICS

The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification

(2011) M. Karus et al.   DEVELOPMENT

Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo

(2011) Ashly Brown et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

(2011) Sandra Blaess et al.   Neural Development

Cell Therapeutics in Parkinson’s Disease

(2011) Olle Lindvall et al.   Neurotherapeutics

Towards stem cell replacement therapies for Parkinson’s disease

(2010) Ernest Arenas   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell transplantation in Parkinsonʼs disease: problems and perspectives

(2010) Laura E Allan et al.   CURRENT OPINION IN NEUROLOGY

Isthmus organizer for mesencephalon and metencephalon

(2010) Harukazu Nakamura et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate

(2010) Juan Antonio Moreno-Bravo et al.   DEVELOPMENTAL DYNAMICS

Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants

(2010) M. Politis et al.   Science Translational Medicine

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

(2009) N. Prakash et al.   DEVELOPMENT

Organization of the human embryonic ventral mesencephalon

(2009) Jenny Nelander et al.   GENE EXPRESSION PATTERNS

Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics

(2009) Josephine B. Hebsgaard et al.   GLIA

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Spatiotemporally separableShhdomains in the midbrain define distinct dopaminergic progenitor pools

(2009) Milan Joksimovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Ciliogenesis

(2009) A. M. Ashique et al.   Science Signaling

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

(2008) D. Omodei et al.   DEVELOPMENT

Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors

(2008) Sonia Bonilla et al.   GLIA

Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL

(2008) Vipul C. Chitalia et al.   NATURE CELL BIOLOGY

Research in motion: the enigma of Parkinson's disease pathology spread

(2008) Patrik Brundin et al.   NATURE REVIEWS NEUROSCIENCE