ST2 as checkpoint target for colorectal cancer immunotherapy

IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation

(2019) Amir H. Ameri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

(2019) Jun Wang et al.   NATURE MEDICINE

IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation

(2019) Aurora Holgado et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells

(2019) Brad Griesenauer et al.   JOURNAL OF IMMUNOLOGY

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer

(2019) Eva Pastille et al.   Mucosal Immunology

An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion

(2019) Aikaterini Hatzioannou et al.   NATURE IMMUNOLOGY

Defining and Understanding Adaptive Resistance in Cancer Immunotherapy

(2018) Tae Kon Kim et al.   TRENDS IN IMMUNOLOGY

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

(2018) Mirjana Efremova et al.   Nature Communications

Emerging strategies for combination checkpoint modulators in cancer immunotherapy

(2018) Aleksandra Popovic et al.   JOURNAL OF CLINICAL INVESTIGATION

Drug resistance and new therapies in colorectal cancer

(2018) Kevin Van der Jeught et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II

(2018) Yujing Li et al.   Nature Communications

LAG3 (CD223) as a cancer immunotherapy target

(2017) Lawrence P. Andrews et al.   IMMUNOLOGICAL REVIEWS

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

(2017) Abdulraouf Ramadan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases

(2017) Kiah L. Butler et al.   Scientific Reports

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting the tumor microenvironment to enhance antitumor immune responses

(2015) Kevin Van der Jeught et al.   Oncotarget

Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

(2014) John C Castle et al.   BMC GENOMICS

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series

(2012) M. A. Merok et al.   ANNALS OF ONCOLOGY

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

(2011) Peng Qiu et al.   NATURE BIOTECHNOLOGY

Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice

(2010) Xiang Zhiguang et al.   IMMUNOLOGY LETTERS

Clinical Relevance of Microsatellite Instability in Colorectal Cancer

(2010) Albert de la Chapelle et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-33–activated dendritic cells induce an atypical TH2-type response

(2009) Matthew A. Rank et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One