ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

(2019) Sam C. Nalle et al.   JOURNAL OF CLINICAL INVESTIGATION

BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease

(2018) Evelyn Ullrich et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide

(2017) Christopher G. Kanakry et al.   HAEMATOLOGICA

Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells

(2017) Norihito Hayatsu et al.   IMMUNITY

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

(2017) Abdulraouf Ramadan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide

(2017) Christopher G. Kanakry et al.   HAEMATOLOGICA

STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter

(2017) Kenji Tago et al.   FEBS Open Bio

The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases

(2017) Brad Griesenauer et al.   Frontiers in Immunology

Plasma biomarkers of risk for death in a multicenter phase 3 trial with uniform transplant characteristics post–allogeneic HCT

(2016) Mohammad Abu Zaid et al.   BLOOD

Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD

(2016) B. M. Matta et al.   BLOOD

Pathogenesis of acute graft-versus-host disease: from intestinal microbiota alterations to donor T cell activation

(2016) Robert Zeiser et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12

(2016) Mousa Komai-Koma et al.   IMMUNOBIOLOGY

Biomarker Panel for Chronic Graft-Versus-Host Disease

(2016) Jeffrey Yu et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

(2016) Mª Carmen Herrero-Sánchez et al.   Journal of Hematology & Oncology

Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival

(2016) Christopher M. Borges et al.   TRANSPLANT INTERNATIONAL

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

(2016) Emily R. Mercadante et al.   Frontiers in Immunology

Danger Signals and Graft-versus-host Disease: Current Understanding and Future Perspectives

(2016) Tomomi Toubai et al.   Frontiers in Immunology

IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release

(2016) Julia Siede et al.   PLoS One

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

(2015) D. K. Reichenbach et al.   BLOOD

Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment

(2015) G. B. McDonald et al.   BLOOD

Effect of upregulated TLR2 expression from G-CSF-mobilized donor grafts on acute graft-versus-host disease

(2015) Won-Sik Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cytokines in Graft-versus-Host Disease

(2015) Andrea S. Henden et al.   JOURNAL OF IMMUNOLOGY

CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response

(2015) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis

(2015) Niranjan Butchi et al.   JOURNAL OF VIROLOGY

T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses

(2015) Claudia Baumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

(2015) Jilu Zhang et al.   Science Translational Medicine

Various Forms of Tissue Damage and Danger Signals Following Hematopoietic Stem-Cell Transplantation

(2015) Abdulraouf Ramadan et al.   Frontiers in Immunology

A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study

(2015) John E Levine et al.   Lancet Haematology

Metagenomic Analysis of the Stool Microbiome in Patients Receiving Allogeneic Stem Cell Transplantation: Loss of Diversity Is Associated with Use of Systemic Antibiotics and More Pronounced in Gastrointestinal Graft-versus-Host Disease

(2014) Ernst Holler et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation

(2014) Doris M. Ponce et al.   BLOOD

The biology of graft-versus-host disease: experimental systems instructing clinical practice

(2014) K. A. Markey et al.   BLOOD

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

(2014) Y. Taur et al.   BLOOD

STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

(2014) Wanqiang Sheng et al.   CELL RESEARCH

Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells

(2014) Dominik Schenten et al.   IMMUNITY

MyD88 Plays a Critical T Cell-Intrinsic Role in Supporting CD8 T Cell Expansion during Acute Lymphocytic Choriomeningitis Virus Infection

(2014) A. H. Rahman et al.   JOURNAL OF IMMUNOLOGY

The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease

(2014) M. Fukata et al.   JOURNAL OF IMMUNOLOGY

IL-33 Induces Antigen-Specific IL-5+ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

(2014) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

T cell-intrinsic role of IL-6 signaling in primary and memory responses

(2014) Simone A Nish et al.   eLife

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 Enhances the Activity of the TLR-MyD88-STAT3 Pathway but Not the Classical TLR-MyD88-NF- B Pathway in Human B Cells To Boost Antibody Production

(2013) B.-S. Liu et al.   JOURNAL OF IMMUNOLOGY

ST2 as a Marker for Risk of Therapy-Resistant Graft-versus-Host Disease and Death

(2013) Mark T. Vander Lugt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Kinetics of IL-6 Production Defines T Effector Cell Responsiveness to Regulatory T Cells in Multiple Sclerosis

(2013) Bettina Trinschek et al.   PLoS One

In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6-Mediated Signaling

(2013) A. Schneider et al.   Science Translational Medicine

IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent

(2012) Zhonghan Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Defining the Role of Sirolimus in the Management of Graft-versus-Host Disease: From Prophylaxis to Treatment

(2012) Ahmed Abouelnasr et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

(2012) Yi Zhao et al.   Cellular & Molecular Immunology

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

(2012) Robert R. Jenq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis

(2012) D Piehler et al.   Mucosal Immunology

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

(2012) Haifa H Jabara et al.   NATURE IMMUNOLOGY

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat3 Phosphorylation Mediates Resistance of Primary Human T Cells to Regulatory T Cell Suppression

(2011) W. A. Goodman et al.   JOURNAL OF IMMUNOLOGY

Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation

(2010) I. Tawara et al.   CLINICAL CANCER RESEARCH

MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease

(2010) M. M. Heimesaat et al.   GUT

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

(2010) José M. González-Navajas et al.   JOURNAL OF CLINICAL INVESTIGATION

Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells

(2010) H. Li et al.   JOURNAL OF IMMUNOLOGY

MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus

(2009) Yosuke Yamawaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

IL-15 Renders Conventional Lymphocytes Resistant to Suppressive Functions of Regulatory T Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway

(2009) M. B. Ahmed et al.   JOURNAL OF IMMUNOLOGY

The Adaptor Molecule MyD88 Directly Promotes CD8 T Cell Responses to Vaccinia Virus

(2009) Yuan Zhao et al.   JOURNAL OF IMMUNOLOGY

MyD88 Intrinsically Regulates CD4 T-Cell Responses

(2008) S. Zhou et al.   JOURNAL OF VIROLOGY