Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications
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Title
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications
Authors
Keywords
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Journal
Pharmaceutics
Volume 12, Issue 7, Pages 649
Publisher
MDPI AG
Online
2020-07-10
DOI
10.3390/pharmaceutics12070649
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Note: Only part of the references are listed.- Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy
- (2020) Yazhe Wang et al. ACS Applied Materials & Interfaces
- Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles
- (2020) Kuldeep K. Bansal et al. Applied Sciences-Basel
- Ultrasound Responsive Magnetic Mesoporous Silica Nanoparticle-Loaded Microbubbles for Efficient Gene Delivery
- (2020) Meng Du et al. ACS Biomaterials-Science & Engineering
- Supercritically dried superparamagnetic mesoporous silica nanoparticles for cancer theranostics
- (2020) Joana Vaz-Ramos et al. Materials Science & Engineering C-Materials for Biological Applications
- Charge-Selective Delivery of Proteins Using Mesoporous Silica Nanoparticles Fused with Lipid Bilayers
- (2019) Hongdong Shi et al. ACS Applied Materials & Interfaces
- Organic/inorganic nanohybrids as multifunctional gene delivery systems
- (2019) Kangli Guo et al. JOURNAL OF GENE MEDICINE
- Silica cloaking of adenovirus enhances gene delivery while reducing immunogenicity
- (2019) Ajay A. Sapre et al. JOURNAL OF CONTROLLED RELEASE
- Biodegradable hybrid mesoporous silica nanoparticles for gene/chemo-synergetic therapy of breast cancer
- (2019) Beibei Zhang et al. JOURNAL OF BIOMATERIALS APPLICATIONS
- Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery
- (2019) Zhe Li et al. Expert Opinion on Drug Delivery
- Silica coated iron oxide nanoparticles-induced cytotoxicity, genotoxicity and its underlying mechanism in human HK-2 renal proximal tubule epithelial cells
- (2019) Karel Královec et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Cumulative directional calcium gluing between phosphate and silicate: A facile, robust and biocompatible strategy for siRNA delivery by amine-free non-positive vector
- (2019) Eunshil Choi et al. BIOMATERIALS
- Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis
- (2019) Ye Yang et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Functionalized mesoporous silica nanoparticles in anticancer therapeutics
- (2019) Abul Barkat et al. SEMINARS IN CANCER BIOLOGY
- Nanosilica: Recent Progress in Synthesis, Functionalization, Biocompatibility, and Biomedical Applications
- (2019) Priti Singh et al. ACS Biomaterials-Science & Engineering
- Evaluation of in vitro toxicity of silica nanoparticles (NPs) to lung cells: Influence of cell types and pulmonary surfactant component DPPC
- (2019) Jing Li et al. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer grafted mesoporous silica nanoparticles for drug and gene co-delivery in vitro
- (2019) Shuai Zhou et al. Materials Science & Engineering C-Materials for Biological Applications
- Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing
- (2018) Coline Pinese et al. Acta Biomaterialia
- Biopebbles: DNA-Functionalized Core-Shell Silica Nanospheres for Cellular Uptake and Cell Guidance Studies
- (2018) Arnold Leidner et al. ADVANCED FUNCTIONAL MATERIALS
- Porous Porphyrin-Based Organosilica Nanoparticles for NIR Two-Photon Photodynamic Therapy and Gene Delivery in Zebrafish
- (2018) Chiara Mauriello Jimenez et al. ADVANCED FUNCTIONAL MATERIALS
- Disulfide-Bridged Organosilica Frameworks: Designed, Synthesis, Redox-Triggered Biodegradation, and Nanobiomedical Applications
- (2018) Xin Du et al. ADVANCED FUNCTIONAL MATERIALS
- Shape-controlled magnetic mesoporous silica nanoparticles for magnetically-mediated suicide gene therapy of hepatocellular carcinoma
- (2018) Zheng Wang et al. BIOMATERIALS
- Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics
- (2018) Jianliang Shen et al. CHEMICAL SOCIETY REVIEWS
- Nonviral Delivery Systems for Cancer Gene Therapy: Strategies and Challenges
- (2018) Gayong Shim et al. CURRENT GENE THERAPY
- Co-delivery of sorafenib and siVEGF based on mesoporous silica nanoparticles for ASGPR mediated targeted HCC therapy
- (2018) Guirong Zheng et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Lyophilization and stability of antibody-conjugated mesoporous silica nanoparticle with cationic polymer and PEG for siRNA delivery
- (2018) Worapol Ngamcherdtrakul et al. International Journal of Nanomedicine
- Functionalization of silica nanoparticles for nucleic acid delivery
- (2018) Rimpei Kamegawa et al. Nano Research
- Enhanced gene delivery by polyethyleneimine coated mesoporous silica nanoparticles
- (2018) Hassan Zarei et al. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
- Mesoporous silica nanoparticles for drug and gene delivery
- (2018) Yixian Zhou et al. Acta Pharmaceutica Sinica B
- Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery
- (2018) Anna Slita et al. Asian Journal of Pharmaceutical Sciences
- Delivery of MTH1 inhibitor (TH287) and MDR1 siRNA via hyaluronic acid-based mesoporous silica nanoparticles for oral cancers treatment
- (2018) Xiao-Lei Shi et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Dual targeting delivery of miR-328 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy
- (2018) Yang Li et al. Nanomedicine
- The toxicity of silica nanoparticles to the immune system
- (2018) Liangjiao Chen et al. Nanomedicine
- Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances
- (2018) Reema Narayan et al. Pharmaceutics
- Genotoxicity of amorphous silica nanoparticles: Status and prospects
- (2018) Mostafa Yazdimamaghani et al. Nanomedicine-Nanotechnology Biology and Medicine
- Nanoengineered silica: Properties, applications and toxicity
- (2017) Andrea M. Mebert et al. FOOD AND CHEMICAL TOXICOLOGY
- Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma
- (2017) Huiying Xue et al. International Journal of Nanomedicine
- Targeted Treatment of Metastatic Breast Cancer by PLK1 siRNA Delivered by an Antioxidant Nanoparticle Platform
- (2017) Jingga Morry et al. MOLECULAR CANCER THERAPEUTICS
- Lipid Bilayer-Gated Mesoporous Silica Nanocarriers for Tumor-Targeted Delivery of Zoledronic Acid in Vivo
- (2017) Diti Desai et al. MOLECULAR PHARMACEUTICS
- Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells
- (2017) Cédric Pisani et al. Nanotoxicology
- Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications
- (2017) Jonas G. Croissant et al. Advanced Healthcare Materials
- Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayer-modified magnetic mesoporous silica nanocomposites
- (2017) Hong Yang et al. Biomaterials Science
- A redox-responsive strategy using mesoporous silica nanoparticles for co-delivery of siRNA and doxorubicin
- (2017) Shuang Zhao et al. Journal of Materials Chemistry B
- Dual delivery of siRNA and plasmid DNA using mesoporous silica nanoparticles to differentiate induced pluripotent stem cells into dopaminergic neurons
- (2017) Jen-Hsuan Chang et al. Journal of Materials Chemistry B
- Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer
- (2017) et al. Nanomaterials
- Recent Advances in Nanomaterials for Gene Delivery—A Review
- (2017) Michael Riley et al. Nanomaterials
- The Serum-Resistant Transfection Evaluation and Long-Term Stability of Gene Delivery Dry Powder Based on Mesoporous Silica Nanoparticles and Polyethyleneimine by Freezing-Drying
- (2016) Xiaoxu Zhang et al. AAPS PHARMSCITECH
- Folate-Functionalized Magnetic-Mesoporous Silica Nanoparticles for Drug/Gene Codelivery To Potentiate the Antitumor Efficacy
- (2016) Tingting Li et al. ACS Applied Materials & Interfaces
- Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells
- (2016) Paul N. Durfee et al. ACS Nano
- Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy
- (2016) Meiying Wu et al. ADVANCED MATERIALS
- Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery
- (2016) Xin Du et al. BIOMATERIALS
- Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery
- (2016) Neeraj Prabhakar et al. International Journal of Nanomedicine
- Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery
- (2016) Yujie Li et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Advances in silica based nanoparticles for targeted cancer therapy
- (2016) Yannan Yang et al. Nanomedicine-Nanotechnology Biology and Medicine
- Highly efficient siRNA delivery from core–shell mesoporous silica nanoparticles with multifunctional polymer caps
- (2016) Karin Möller et al. Nanoscale
- NIR-Responsive Polycationic Gatekeeper-Cloaked Hetero-Nanoparticles for Multimodal Imaging-Guided Triple-Combination Therapy of Cancer
- (2016) Shun Duan et al. Small
- Magnetic Core-Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery
- (2016) Lin Xiong et al. Small
- In-depth study on the gene silencing capability of silica nanoparticles with different pore sizes: degree and duration of RNA interference
- (2016) Seongchan Kim et al. RSC Advances
- Recent progress in nanomaterials for gene delivery applications
- (2016) Erhan Keles et al. Biomaterials Science
- Utilising inorganic nanocarriers for gene delivery
- (2016) Xian Jun Loh et al. Biomaterials Science
- Silica nanoparticle-generated ROS as a predictor of cellular toxicity: mechanistic insights and safety by design
- (2016) Sean E. Lehman et al. Environmental Science-Nano
- Facile Synthesis of Large-Pore Bicontinuous Cubic Mesoporous Silica Nanoparticles for Intracellular Gene Delivery
- (2016) Anand Kumar Meka et al. ChemNanoMat
- Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice
- (2015) Huan Meng et al. ACS Nano
- The shape and size effects of polycation functionalized silica nanoparticles on gene transfection
- (2015) Xinyi Lin et al. Acta Biomaterialia
- Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer
- (2015) Worapol Ngamcherdtrakul et al. ADVANCED FUNCTIONAL MATERIALS
- Genotoxicity of mesoporous silica nanoparticles in human embryonic kidney 293 cells
- (2015) Quanan Zhang et al. Drug Testing and Analysis
- Quaternary Ammonium Groups Exposed at the Surface of Silica Nanoparticles Suitable for DNA Complexation in the Presence of Cationic Lipids
- (2015) Nora Reinhardt et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Size-dependent gene delivery of amine-modified silica nanoparticles
- (2015) Meihua Yu et al. Nano Research
- Toxicity of silica nanoparticles depends on size, dose, and cell type
- (2015) In-Yong Kim et al. Nanomedicine-Nanotechnology Biology and Medicine
- Silica–gold nanoparticles for atheroprotective management of plaques: results of the NANOM-FIM trial
- (2015) Alexander N. Kharlamov et al. Nanoscale
- Gene transfer on inorganic/organic hybrid silica nanosheets
- (2015) Nien-Chi Huang et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Nanosheet transfection: effective transfer of naked DNA on silica glass
- (2015) Nien-Chi Huang et al. NPG Asia Materials
- Silica-coated super-paramagnetic iron oxide nanoparticles (SPIONPs): a new type contrast agent of T1 magnetic resonance imaging (MRI)
- (2015) M. Zubair Iqbal et al. Journal of Materials Chemistry B
- Killing cancer cells using nanotechnology: novel poly(I:C) loaded liposome–silica hybrid nanoparticles
- (2015) Valentina Colapicchioni et al. Journal of Materials Chemistry B
- A facilely controlled length, cytotoxicity, length-dependent and cell type-dependent cellular uptake of silica nanotubes and their applications in the delivery of immunostimulatory CpG oligodeoxynucleotides
- (2015) Song Chen et al. Journal of Materials Chemistry B
- Monodispersed and Ordered Large-Pore Mesoporous Silica Nanospheres with Tunable Pore Structure for Magnetic Functionalization and Gene Delivery
- (2014) Dechao Niu et al. ADVANCED MATERIALS
- Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery
- (2014) Meiying Wu et al. ADVANCED MATERIALS
- Core-Shell-Type Magnetic Mesoporous Silica Nanocomposites for Bioimaging and Therapeutic Agent Delivery
- (2014) Yao Wang et al. ADVANCED MATERIALS
- Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier
- (2014) Yijie Chen et al. BIOMATERIALS
- Improved gene transfer with histidine-functionalized mesoporous silica nanoparticles
- (2014) David Brevet et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Synthesis of multi-functional large pore mesoporous silica nanoparticles as gene carriers
- (2014) Sandy B Hartono et al. NANOTECHNOLOGY
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe
- (2014) E. Phillips et al. Science Translational Medicine
- Synthesis and surface functionalization of silica nanoparticles for nanomedicine
- (2014) Alexander Liberman et al. SURFACE SCIENCE REPORTS
- Virus-Mimetic Cytoplasm-Cleavable Magnetic/Silica Nanoclusters for Enhanced Gene Delivery to Mesenchymal Stem Cells
- (2013) Naveen Gandra et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
- (2013) Ellen C. Dengler et al. JOURNAL OF CONTROLLED RELEASE
- Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis
- (2013) Ayman El-Sayed et al. MOLECULAR THERAPY
- Nonporous silica nanoparticles for nanomedicine application
- (2013) Li Tang et al. Nano Today
- Poly-L-Arginine Grafted Silica Mesoporous Nanoparticles for Enhanced Cellular Uptake and their Application in DNA Delivery and Controlled Drug Release
- (2013) Mrityunjoy Kar et al. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
- Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery
- (2012) Sandy B. Hartono et al. ACS Nano
- Delivery of Small Interfering RNA by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers
- (2012) Carlee E. Ashley et al. ACS Nano
- A mesoporous silica nanoparticle – PEI – Fusogenic peptide system for siRNA delivery in cancer therapy
- (2012) Xu Li et al. BIOMATERIALS
- How long a functionalized carbon nanotube can passively penetrate a lipid membrane
- (2012) Sebastian Kraszewski et al. CARBON
- Silica-based gene reverse transfection: an upright nanosheet network for promoted DNA delivery to cells
- (2012) Qingmin Ji et al. CHEMICAL COMMUNICATIONS
- Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling
- (2012) Eric C. Freeman et al. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
- Novel luminescent silica nanoparticles (LSN): p53 gene delivery system in breast cancer in vitro and in vivo
- (2012) Chandrababu Rejeeth et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Chemically Reducible Lipid Bilayer Coated Mesoporous Silica Nanoparticles Demonstrating Controlled Release and HeLa and Normal Mouse Liver Cell Biocompatibility and Cellular Internalization
- (2012) Robert A. Roggers et al. MOLECULAR PHARMACEUTICS
- Silica-Iron Oxide Magnetic Nanoparticles Modified for Gene Delivery: A Search for Optimum and Quantitative Criteria
- (2012) Olga Mykhaylyk et al. PHARMACEUTICAL RESEARCH
- Facile Synthesis of Monodispersed Mesoporous Silica Nanoparticles with Ultralarge Pores and Their Application in Gene Delivery
- (2011) Mi-Hee Kim et al. ACS Nano
- Stabilization of Soft Lipid Colloids: Competing Effects of Nanoparticle Decoration and Supported Lipid Bilayer Formation
- (2011) Sushma Savarala et al. ACS Nano
- Multifunctional silica nanotubes for dual-modality gene delivery and MR imaging
- (2011) Ran Namgung et al. BIOMATERIALS
- Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
- (2011) Miriam Benezra et al. JOURNAL OF CLINICAL INVESTIGATION
- Templated-assisted one-dimensional silica nanotubes: synthesis and applications
- (2011) Xiaofei Yang et al. JOURNAL OF MATERIALS CHEMISTRY
- Hollow Mesoporous Silica/Poly(l-lysine) Particles for Codelivery of Drug and Gene with Enzyme-Triggered Release Property
- (2011) Yufang Zhu et al. Journal of Physical Chemistry C
- The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers
- (2011) Carlee E. Ashley et al. NATURE MATERIALS
- Biofunctionalized Phospholipid-Capped Mesoporous Silica Nanoshuttles for Targeted Drug Delivery: Improved Water Suspensibility and Decreased Nonspecific Protein Binding
- (2010) Li-Sheng Wang et al. ACS Nano
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- (2010) Jennifer Ziello et al. MOLECULAR MEDICINE
- Colchicine-Loaded Lipid Bilayer-Coated 50 nm Mesoporous Nanoparticles Efficiently Induce Microtubule Depolymerization upon Cell Uptake
- (2010) Valentina Cauda et al. NANO LETTERS
- Enhanced Gene and siRNA Delivery by Polycation-Modified Mesoporous Silica Nanoparticles Loaded with Chloroquine
- (2010) Shanta Raj Bhattarai et al. PHARMACEUTICAL RESEARCH
- Mesoporous Silica Nanoparticles Facilitate Delivery of siRNA to Shutdown Signaling Pathways in Mammalian Cells
- (2010) Christopher Hom et al. Small
- Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs
- (2009) Tian Xia et al. ACS Nano
- The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function
- (2009) Xinglu Huang et al. BIOMATERIALS
- Silica nanoparticle supported lipid bilayers for gene delivery
- (2009) Juewen Liu et al. CHEMICAL COMMUNICATIONS
- Monodispersed Mesoporous Silica Nanoparticles with Very Large Pores for Enhanced Adsorption and Release of DNA
- (2009) Fei Gao et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Mechanical Capping of Silica Nanotubes for Encapsulation of Molecules
- (2009) Jaeeun Yu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Uniform Mesoporous Dye-Doped Silica Nanoparticles Decorated with Multiple Magnetite Nanocrystals for Simultaneous Enhanced Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery
- (2009) Ji Eun Lee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Novel amino-modified silica nanoparticles as efficient vector for hepatocellular carcinoma gene therapy
- (2009) Xuxian Xiao et al. MEDICAL ONCOLOGY
- Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles
- (2009) Fang Lu et al. Small
- Ultrasmall, Well-Dispersed, Hollow Siliceous Spheres with Enhanced Endocytosis Properties
- (2009) Jie Zhu et al. Small
- Mannosylated polyethylenimine coupled mesoporous silica nanoparticles for receptor-mediated gene delivery
- (2008) In Young Park et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Toxicity of amorphous silica nanoparticles in mouse keratinocytes
- (2008) Kyung O. Yu et al. JOURNAL OF NANOPARTICLE RESEARCH
- Improved Biocompatibility and Pharmacokinetics of Silica Nanoparticles by Means of a Lipid Coating: A Multimodality Investigation
- (2008) Matti M. van Schooneveld et al. NANO LETTERS
- Bioconjugated silica nanoparticles: Development and applications
- (2008) Lin Wang et al. Nano Research
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