High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes

Fibroblast Activation Protein (FAP) Overexpression Induces Epithelial–Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma by Down-Regulating Dipeptidyl Peptidase 9 (DPP9)

(2020) Qing-qing Wu et al.   OncoTargets and Therapy

Fibroblast activation protein-positive fibroblasts promote tumor progression through secretion of CCL2 and interleukin-6 in esophageal squamous cell carcinoma

(2019) Nobuhide Higashino et al.   LABORATORY INVESTIGATION

Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

(2019) Tessa P. Sandberg et al.   BMC CANCER

FAPI-PET/CT: Mean intensity of tracer-uptake (SUV) in 28 different kinds of cancer

(2019) Clemens Kratochwil et al.   JOURNAL OF NUCLEAR MEDICINE

Comparisons of cancer-associated fibroblasts in the intratumoral stroma and invasive front in colorectal cancer

(2019) Gyung Mo Son et al.   MEDICINE

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

The prognostic value of tumour stroma ratio and tumour budding in stage II colon cancer. A nationwide population-based study

(2018) Ann Christina Eriksen et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

FAPI-PET/CT: biodistribution and preliminary dosimetry estimate of two DOTA-containing FAP-targeting agents in patients with various cancers

(2018) Frederik Giesel et al.   JOURNAL OF NUCLEAR MEDICINE

Mesenchymal Cells in Colon Cancer

(2017) Vasiliki Koliaraki et al.   GASTROENTEROLOGY

Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016

(2017) Alessandro Lugli et al.   MODERN PATHOLOGY

Fibroblast Activation Protein-α-Positive Fibroblasts Promote Gastric Cancer Progression and Resistance to Immune Checkpoint Blockade

(2017) Xuyang Wen et al.   ONCOLOGY RESEARCH

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models

(2017) Peter W. Eide et al.   Scientific Reports

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Fibroblast activation in cancer: when seed fertilizes soil

(2016) Sanya-Eduarda Kuzet et al.   CELL AND TISSUE RESEARCH

Tumor budding in colorectal cancer—ready for diagnostic practice?

(2016) Viktor H. Koelzer et al.   HUMAN PATHOLOGY

Cyclophosphamide enhances anti-tumor effects of a fibroblast activation protein α-based DNA vaccine in tumor-bearing mice with murine breast carcinoma

(2016) Qiu Xia et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

PD-1 blockade in tumors with mismatch repair deficiency.

(2015) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

(2015) M.M. Koczorowska et al.   Molecular Oncology

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data

(2015) Antonio Colaprico et al.   NUCLEIC ACIDS RESEARCH

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

(2015) Eunyoung Chun et al.   Cell Reports

Immune checkpoints and immunotherapy for colorectal cancer

(2015) Preet Paul Singh et al.   Gastroenterology Report

The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer

(2014) J. H. Park et al.   ANNALS OF ONCOLOGY

The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance

(2014) D. T. Fearon   Cancer Immunology Research

3'-UTR Poly(T/U) Tract Deletions and Altered Expression of EWSR1 Are a Hallmark of Mismatch Repair-Deficient Cancers

(2013) S. Kishore et al.   CANCER RESEARCH

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

(2013) Jérôme Galon et al.   JOURNAL OF PATHOLOGY

High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis

(2013) Maria L. Wikberg et al.   TUMOR BIOLOGY

Fibroblast Activation Protein in Remodeling Tissues

(2012) M. Jacob et al.   CURRENT MOLECULAR MEDICINE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Colorectal Cancer Cells Activate Adjacent Fibroblasts Resulting in FGF1/FGFR3 Signaling and Increased Invasion

(2011) Maria L. Henriksson et al.   AMERICAN JOURNAL OF PATHOLOGY

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Cancer-associated fibroblasts correlate with poor prognosis in rectal cancer after chemoradiotherapy

(2011) Saigusa   INTERNATIONAL JOURNAL OF ONCOLOGY

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

(2009) Robert M Eager et al.   BMC CANCER

Phase II Trial of Talabostat and Docetaxel in Advanced Non-small Cell Lung Cancer

(2009) R.M. Eager et al.   CLINICAL ONCOLOGY

Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

(2009) Markus Loeffler et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

(2009) Angélica M. Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

(2008) E. Ostermann et al.   CLINICAL CANCER RESEARCH