Article
Oncology
Jae Young So, Howard H. Yang, Woo Yong Park, Nicolas Skrypek, Hiroki Ishii, Jennifer M. Chen, Maxwell P. Lee, Li Yang
Summary: This study finds that high expression of DNA methyltransferase 3B (DNMT3B) is associated with poor clinical outcomes in breast cancer patients. Clonal cells with high DNMT3B expression display enhanced epithelial-to-mesenchymal transition capacity, and perioperative targeting of DNMT3B in combination with chemotherapy can significantly suppress tumor recurrence and metastasis.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Hallie M. Hintz, Kristin M. Snyder, Jianming Wu, Robert Hullsiek, James D. Dahlvang, Geoffrey T. Hart, Bruce Walcheck, Aaron M. LeBeau
Summary: The study engineered NK cells to express CD64 and bind antibodies for tumor targeting in mCRPC, showing enhanced cytotoxicity through ADCC. Targeting prostate tumor antigen TROP2 and fibroblast marker FAP, the combination approach demonstrated significantly higher cytotoxicity compared to single mAbs and NK cells alone, suggesting a potential immunotherapy for mCRPC.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Chemistry, Medicinal
Atziri Corin Chavez Alvarez, Chahrazed Bouzriba, Emmanuel Moreau, Philippe Auzeloux, Sophie Besse, Vincent Ouellette, Mitra Zarifi Khosroshahi, Marie-France Cote, Sylvie Pilote, Elisabeth Miot-Noirault, Jean-Michel Chezal, Chantale Simard, Rene C-Gaudreault, Sebastien Fortin
Summary: PAIB-SOs are new antimitotic prodrugs bioactivated in breast cancer cells expressing CYP1A1. Homologation of the alkyl side chain of PAIB-SOs improves their stability and selectivity, and n-pentyl PAIB-SOs show significant antitumor activity and low toxicity. The study confirms the suitability of homologation to enhance the hepatic stability of PAIB-SOs.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Haas de Mello, Camila Medianeira da Silva D'Avila, Altevir Rossato Viana, Luciana Maria Fontanari Krause, Francine Carla Cadona
Summary: This study found that cocoa can reduce the viability and proliferation of melanoma cell lines by increasing oxidative stress, while causing no harm to fibroblast cells. Additionally, cocoa can enhance the activity of paclitaxel on melanoma cells, leading to reduced cell proliferation and increased oxidative stress.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Ya-Ru Wu, Liang Li, Xian-Chang Sun, Jun Wang, Chun-Yan Ma, Yue Zhang, Hui-Lin Qu, Rui-Xia Xu, Jian-Jun Li
Summary: The study found that DADS can significantly reduce PCSK9 expression induced by LPS in HepG2 cells by activating the PI3K/Akt-SREBP2 signaling pathway, leading to an increase in LDLR expression.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Yuge Jiang, Chuanxing Feng, Yonghui Shi, Xingran Kou, Guowei Le
Summary: Eugenol has been found to have potential protective effects on muscle function and prevention of muscle inflammation. It can lower blood glucose and insulin resistance, reduce muscle inflammation induced by a high-fat diet and streptozocin injection, and prevent muscle weakness and atrophy. This may be explained by the increased translocation of GLUT4 and phosphorylation of AMPK in skeletal muscle, resulting in enhanced glucose uptake.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Colin S. Hill, Lauren M. Rosati, Chen Hu, Wei Fu, Shuchi Sehgal, Amy Hacker-Prietz, Christopher L. Wolfgang, Matthew J. Weiss, Richard A. Burkhart, Ralph H. Hruban, Ana De Jesus-Acosta, Dung T. Le, Lei Zheng, Daniel A. Laheru, Jin He, Amol K. Narang, Joseph M. Herman
Summary: Despite having more advanced disease, the nCT-SBRT cohort was still more likely to undergo an R0 resection and experienced similar survival outcomes compared with the nCT alone cohort.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Gavin Pharaoh, Varun Kamat, Sricharan Kannan, Rudolph S. Stuppard, Jeremy Whitson, Miguel Martin-Perez, Wei-Jun Qian, Michael J. MacCoss, Judit Villen, Peter Rabinovitch, Matthew D. Campbell, Ian R. Sweet, David J. Marcinek
Summary: Aging muscle experiences functional decline due to impaired mitochondrial ADP sensitivity. Elamipretide (ELAM) improves physiological and mitochondrial function in aging by increasing ADP sensitivity through the mitochondrial ADP transporter ANT. ELAM treatment increases ADP uptake in old muscle mitochondria, rescuing muscle force and heart systolic function. This research establishes a link between mitochondrial ADP sensitivity and physiological function, supporting the role of ELAM in improving aging muscle function.
