Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

(2019) Chuan-xia Zhang et al.   CELL DEATH AND DIFFERENTIATION

Plasticity of myeloid-derived suppressor cells in cancer

(2018) Evgenii Tcyganov et al.   CURRENT OPINION IN IMMUNOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

EMT: Mechanisms and therapeutic implications

(2018) Mohini Singh et al.   PHARMACOLOGY & THERAPEUTICS

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

(2018) Kazuki Kato et al.   Nature Communications

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

(2017) Bridget Larkin et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP–AMP Synthase Is the Cytosolic Sensor ofPlasmodium falciparumGenomic DNA and Activates Type I IFN in Malaria

(2017) Carolina Gallego-Marin et al.   JOURNAL OF IMMUNOLOGY

A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection

(2017) Jessica L. Smith et al.   JOURNAL OF VIROLOGY

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

(2017) Hua Liang et al.   Nature Communications

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

(2017) Maria Ouzounova et al.   Nature Communications

CXCR2+ MDSCs promote breast cancer progression by inducing EMT and activated T cell exhaustion

(2017) Ha Zhu et al.   Oncotarget

Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma

(2017) Yago Pico de Coana et al.   Oncotarget

Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation

(2017) Xin Guo et al.   Scientific Reports

Stat6 Promotes Intestinal Tumorigenesis in a Mouse Model of Adenomatous Polyposis by Expansion of MDSCs and Inhibition of Cytotoxic CD8 Response

(2017) Asha Jayakumar et al.   NEOPLASIA

Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells

(2017) et al.   Cancers

Clinical Significance of Circulating CD33+CD11b+HLA-DR- Myeloid Cells in Patients with Stage IV Melanoma Treated with Ipilimumab

(2016) M. Sade-Feldman et al.   CLINICAL CANCER RESEARCH

Frontline Science: Myeloid-derived suppressor cells (MDSCs) facilitate maternal–fetal tolerance in mice

(2016) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

(2016) Tiejun Li et al.   Scientific Reports

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

(2015) Thomas Condamine et al.   Annual Review of Medicine

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer

(2015) L. Corrales et al.   CLINICAL CANCER RESEARCH

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Obesity Triggers Enhanced MDSC Accumulation in Murine Renal Tumors via Elevated Local Production of CCL2

(2015) Malika Hale et al.   PLoS One

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis

(2013) Junchao Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipocytes as a critical component of the tumor microenvironment

(2013) Linda Vona-Davis et al.   LEUKEMIA RESEARCH

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Mitotic and mitogenic Wnt signalling

(2012) Christof Niehrs et al.   EMBO JOURNAL

Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species

(2011) Robert S. Tacke et al.   HEPATOLOGY

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

(2011) Benjamin Toh et al.   PLOS BIOLOGY

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL