Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway

(2019) Jiaomeng Pan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Modeling cancer drug response through drug-specific informative genes

(2019) Luca Parca et al.   Scientific Reports

The contributions of cancer cell metabolism to metastasis

(2018) Gloria Pascual et al.   Disease Models & Mechanisms

Colorectal cancer lung metastasis treatment with polymer–drug nanoparticles

(2018) Piotr Rychahou et al.   JOURNAL OF CONTROLLED RELEASE

Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization

(2018) Jan F. C. Glatz et al.   JOURNAL OF LIPID RESEARCH

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

(2018) Yekaterina Y. Zaytseva et al.   Oncotarget

Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?

(2018) Ana-Maria Enciu et al.   Biomed Research International

Abstract 1437: De novo fatty acid synthesis-driven sphingolipid metabolism promotes metastatic potential of colorectal cancer

(2018) Naser Jafari et al.   CANCER RESEARCH

De Novo Fatty Acid Synthesis Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer

(2018) Naser Jafari et al.   MOLECULAR CANCER RESEARCH

CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells

(2018) Yu Liang et al.   Oncogenesis

Exogenous lipids promote the growth of breast cancer cells via CD36

(2017) Jing Zhao et al.   ONCOLOGY REPORTS

Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target

(2017) Douglas Buckley et al.   PHARMACOLOGY & THERAPEUTICS

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

(2017) Timothy S. Heuer et al.   EBioMedicine

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

(2016) Joost J.F.P. Luiken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Survivin: a unique target for tumor therapy

(2016) Himani Garg et al.   Cancer Cell International

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Bothde novosynthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells

(2016) Dan Cao et al.   LIVER INTERNATIONAL

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Abstract 2675: Biomarker and PK/PD analyses of first in class FASN inhibitor TVB-2640 in a first-in-human phase 1 study in solid tumor patients

(2015) Marie O'Farrell et al.   CANCER RESEARCH

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?

(2015) Seher Balaban et al.   Biomed Research International

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

(2015) Richard Ventura et al.   EBioMedicine

Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

(2014) Marta Yanina Pepino et al.   Annual Review of Nutrition

Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer

(2014) Yekaterina Y. Zaytseva et al.   CARCINOGENESIS

Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells

(2014) Ji Tae Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Obesity and cancer—mechanisms underlying tumour progression and recurrence

(2014) Jiyoung Park et al.   Nature Reviews Endocrinology

Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

(2014) James S. Hale et al.   STEM CELLS

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Increased Saturated Fatty Acids in Obesity Alter Resolution of Inflammation in Part by Stimulating Prostaglandin Production

(2013) J. Hellmann et al.   JOURNAL OF IMMUNOLOGY

ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer

(2013) Q Ye et al.   ONCOGENE

Epigenetic and genetic features of 24 colon cancer cell lines

(2013) D Ahmed et al.   Oncogenesis

Targeting survivin in cancer

(2012) Dario C. Altieri   CANCER LETTERS

Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer

(2012) Y. Y. Zaytseva et al.   CANCER RESEARCH

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

(2012) S. Julien et al.   CLINICAL CANCER RESEARCH

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Complete deletion of Apc results in severe polyposis in mice

(2009) A F Cheung et al.   ONCOGENE

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling