Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H2S/Cav3.2 Signaling in Mice

Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL/6 mice

(2019) Kazuki Matsui et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

(2019) Yam Nath Paudel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants

(2019) Maho Tsubota et al.   Journal of Neuroinflammation

Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers

(2018) Huy Du Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca v 3.2 in mice

(2018) Tomoka Ozaki et al.   TOXICOLOGY

Role of P2X4 Receptor in Mouse Voiding Function

(2018) Weiqun Yu et al.   Scientific Reports

RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer—a Review

(2018) Gowri Palanissami et al.   Hormones & Cancer

Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk

(2018) Fumiko Sekiguchi et al.   NEUROPHARMACOLOGY

ATP Evokes Ca2+Responses and CXCL5 Secretion via P2X4Receptor Activation in Human Monocyte-Derived Macrophages

(2017) Janice A. Layhadi et al.   JOURNAL OF IMMUNOLOGY

Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis

(2017) Yuhei Irie et al.   Journal of Neuroimmune Pharmacology

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

(2016) Daichi Yamasoba et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

(2016) Wolfgang Fischer et al.   PLoS One

Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells

(2014) Fumiko Sekiguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation

(2014) Zhiyong Yang et al.   JOURNAL OF IMMUNOLOGY

Ulcerative and Nonulcerative Forms of Bladder Pain Syndrome/Interstitial Cystitis Do Not Differ in Symptom Intensity or Response to Onabotulinum Toxin A

(2014) Rui Pinto et al.   UROLOGY

Bladder pain relief by HMGB1 neutralization and soluble thrombomodulin in mice with cyclophosphamide-induced cystitis

(2013) Junichi Tanaka et al.   NEUROPHARMACOLOGY

Involvement of the endogenous hydrogen sulfide/Cav3.2 T-type Ca2+channel pathway in cystitis-related bladder pain in mice

(2012) Maho Matsunami et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-Substituted Phenoxazine and Acridone Derivatives: Structure–Activity Relationships of Potent P2X4 Receptor Antagonists

(2012) Victor Hernandez-Olmos et al.   JOURNAL OF MEDICINAL CHEMISTRY

The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain

(2012) Polina Feldman et al.   Journal of Neuroinflammation

Dengue Virus Infection Mediates HMGB1 Release from Monocytes Involving PCAF Acetylase Complex and Induces Vascular Leakage in Endothelial Cells

(2012) Siew Pei Ong et al.   PLoS One

The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice

(2011) JP Martins et al.   BRITISH JOURNAL OF PHARMACOLOGY

LPS Induces HMGB1 Relocation and Release by Activating the NF-κB-CBP Signal Transduction Pathway in the Murine Macrophage-Like Cell Line RAW264.7

(2011) Chuan-Xin Wu et al.   JOURNAL OF SURGICAL RESEARCH

Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse

(2011) Vinícios T. Boeira et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis

(2011) Takahiro Miki et al.   PAIN

P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain

(2010) Lauriane Ulmann et al.   EMBO JOURNAL

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY