Role of FOXO Transcription Factors in Cancer Metabolism and Angiogenesis

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth

(2019) Sameer H. Issaq et al.   Oncogenesis

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

(2019) Lisha Xiang et al.   Cell Death & Disease

Lipid metabolism in cancer cells under metabolic stress

(2019) Rimsha Munir et al.   BRITISH JOURNAL OF CANCER

Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis

(2019) Miao Lu et al.   BMC CANCER

The FoxO–Autophagy Axis in Health and Disease

(2019) Zhiyong Cheng   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Tumor Vessel Targeting Strategy: A Double-Edged Sword in Tumor Metastasis

(2019) Xiaobo Li et al.   Cells

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

(2018) Brent E. Fitzwalter et al.   DEVELOPMENTAL CELL

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

FoxO transcription factors in cancer metabolism

(2018) Raj Kumar Yadav et al.   SEMINARS IN CANCER BIOLOGY

Re-evaluating the role of FOXOs in cancer

(2018) M. Hornsveld et al.   SEMINARS IN CANCER BIOLOGY

Autophagy inhibition improves anti-cancer drugs via FOXO3a activation

(2018) Brent E. Fitzwalter et al.   Oncotarget

Unraveling the Role of Angiogenesis in Cancer Ecosystems

(2018) Iratxe Zuazo-Gaztelu et al.   Frontiers in Oncology

Arsenic Trioxide Suppressed Migration and Angiogenesis by Targeting FOXO3a in Gastric Cancer Cells

(2018) Lin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FOXO Signaling Pathways as Therapeutic Targets in Cancer

(2017) Mohd Farhan et al.   International Journal of Biological Sciences

Overexpression of FoxO3a is associated with glioblastoma progression and predicts poor patient prognosis

(2017) Zhongrun Qian et al.   INTERNATIONAL JOURNAL OF CANCER

Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?

(2017) Xianwang Wang et al.   Oncology Letters

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

(2017) Zhen-Dong Xiao et al.   Nature Communications

Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis

(2017) Shiri Procaccia et al.   Scientific Reports

The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy

(2016) Jing Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Angiogenesis and wound repair: when enough is enough

(2016) Luisa A. DiPietro   JOURNAL OF LEUKOCYTE BIOLOGY

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

FOXO3 is essential for CD44 expression in pancreatic cancer cells

(2016) M Kumazoe et al.   ONCOGENE

Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma

(2016) Judith Hagenbuchner et al.   Oncotarget

FOXO1 inhibits the invasion and metastasis of hepatocellular carcinoma by reversing ZEB2-induced epithelial-mesenchymal transition

(2016) Tianxiu Dong et al.   Oncotarget

Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1

(2016) Sue Youn Kim et al.   Cancer Research and Treatment

Evolutionary Acquisition of Cysteines Determines FOXO Paralog-Specific Redox Signaling

(2015) Marrit Putker et al.   ANTIOXIDANTS & REDOX SIGNALING

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor

(2015) Y. Zhao et al.   ONCOLOGIST

Gluconeogenesis combats cancer: opening new doors in cancer biology

(2015) M W Khan et al.   Cell Death & Disease

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

(2015) Huanjie Shao et al.   Oncotarget

Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma

(2015) Decai Yu et al.   Oncotarget

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Downregulation of FOXO3a Promotes Tumor Metastasis and Is Associated with Metastasis-Free Survival of Patients with Clear Cell Renal Cell Carcinoma

(2014) D. Ni et al.   CLINICAL CANCER RESEARCH

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

A Genome-Wide RNAi Screen Identifies FOXO4 as a Metastasis-Suppressor through Counteracting PI3K/AKT Signal Pathway in Prostate Cancer

(2014) Bing Su et al.   PLoS One

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation

(2014) Shoshana M. Bartell et al.   Nature Communications

Analysis of FOXO1 mutations in diffuse large B-cell lymphoma

(2013) D. L. Trinh et al.   BLOOD

FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role

(2013) M D Bullock et al.   BRITISH JOURNAL OF CANCER

FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma

(2013) E. E. Santo et al.   CANCER RESEARCH

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Redox-Dependent Control of FOXO/DAF-16 by Transportin-1

(2013) Marrit Putker et al.   MOLECULAR CELL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme

(2013) Anna Rosati et al.   NEURO-ONCOLOGY

Involvement of post-transcriptional regulation of FOXO1 by HuR in 5-FU-induced apoptosis in breast cancer cells

(2013) YUNBO LI et al.   Oncology Letters

Antagonism between FOXO and MYC Regulates Cellular Powerhouse

(2013) Barrie Peck et al.   Frontiers in Oncology

Glutamine metabolism links growth factor signaling to the regulation of autophagy

(2012) Kristan E. van der Vos et al.   Autophagy

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

FoxO1 Inhibits Sterol Regulatory Element-binding Protein-1c (SREBP-1c) Gene Expression via Transcription Factors Sp1 and SREBP-1c

(2012) Xiong Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

(2011) Sue Youn Kim et al.   BMC CANCER

FOXO3a nuclear localisation is associated with good prognosis in luminal-like breast cancer

(2011) Hany Onsy Habashy et al.   BREAST CANCER RESEARCH AND TREATMENT

FoxO family members in cancer

(2011) Yuqing Zhang et al.   CANCER BIOLOGY & THERAPY

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

(2011) Stephen M. Sykes et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

(2011) E C Ferber et al.   CELL DEATH AND DIFFERENTIATION

Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells

(2011) X. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis

(2011) Theresia R. Kress et al.   MOLECULAR CELL

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression

(2011) Stefano Amente et al.   NUCLEIC ACIDS RESEARCH

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer

(2011) C T Karadedou et al.   ONCOGENE

FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis

(2010) Boyi Gan et al.   CANCER CELL

Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence

(2010) P. L. J. de Keizer et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer

(2010) Jie Chen et al.   PLoS One

Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

(2010) Qinghe Chen et al.   PLoS One

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Prognostic Significance of Phosphorylated FOXO1 Expression in Soft Tissue Sarcoma

(2009) Binglin Zhang et al.   ANNALS OF SURGICAL ONCOLOGY

The paradox of autophagy and its implication in cancer etiology and therapy

(2009) Avital Eisenberg-Lerner et al.   APOPTOSIS

FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes

(2009) Partha Chakrabarti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics

(2009) Carlos M. Santamaría et al.   LEUKEMIA RESEARCH

FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases

(2009) P. Storz et al.   MOLECULAR AND CELLULAR BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The involvement of FOXO1 in cytotoxic stress and drug-resistance induced by paclitaxel in ovarian cancers

(2008) T Goto et al.   BRITISH JOURNAL OF CANCER

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells

(2008) C.-Y. Han et al.   CARCINOGENESIS

O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene

(2008) MeiShiue Kuo et al.   FEBS LETTERS

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

(2008) R. C-Y. Hui et al.   MOLECULAR CANCER THERAPEUTICS

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unravelling the tumor-suppressive functions of FOXO proteins

(2008) Tobias B. Dansen et al.   TRENDS IN CELL BIOLOGY