Redirecting T Cells against Epstein–Barr Virus Infection and Associated Oncogenesis

Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection

(2020) Stuart G. Tangye et al.   BLOOD

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

(2020) Enli Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

(2020) Kristen Fousek et al.   LEUKEMIA

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

(2020) Michael Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice

(2020) Nicole Caduff et al.   PLoS Pathogens

Current Challenges in Providing Good Leukapheresis Products for Manufacturing of CAR-T Cells for Patients with Relapsed/Refractory NHL or ALL

(2020) Felix Korell et al.   Cells

MicroRNAs of Epstein-Barr Virus Attenuate T-Cell-Mediated Immune Control In Vivo

(2019) Anita Murer et al.   mBio

Defective Epstein–Barr virus in chronic active infection and haematological malignancy

(2019) Yusuke Okuno et al.   Nature Microbiology

Heterologous prime-boost vaccination protects against EBV antigen–expressing lymphomas

(2019) Julia Rühl et al.   JOURNAL OF CLINICAL INVESTIGATION

Infection and immune control of human oncogenic γ-herpesviruses in humanized mice

(2019) Donal McHugh et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo

(2019) Bithi Chatterjee et al.   PLoS Pathogens

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

(2019) Benjamin J. Meckiff et al.   JOURNAL OF IMMUNOLOGY

Signaling pathways involved in the T‐cell‐mediated immunity against Epstein‐Barr virus: Lessons from genetic diseases

(2019) Sylvain Latour et al.   IMMUNOLOGICAL REVIEWS

Latency and lytic replication in Epstein–Barr virus-associated oncogenesis

(2019) Christian Münz   NATURE REVIEWS MICROBIOLOGY

First Days in the Life of Naive Human B Lymphocytes Infected with Epstein-Barr Virus

(2019) Dagmar Pich et al.   mBio

The T-cell Response to Epstein-Barr Virus–New Tricks From an Old Dog

(2019) Heather M. Long et al.   Frontiers in Immunology

The Global Landscape of EBV-Associated Tumors

(2019) Claire Shannon-Lowe et al.   Frontiers in Oncology

Common variable immune deficiency: case studies

(2019) Charlotte Cunningham-Rundles   BLOOD

CD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo

(2019) Xiaojun Tang et al.   OncoTargets and Therapy

Cell therapies for hematological malignancies: don't forget non-gene-modified t cells!

(2018) Melanie L. Grant et al.   BLOOD REVIEWS

A novel Epstein–Barr virus-latent membrane protein-1-specific T-cell receptor for TCR gene therapy

(2018) Hyun-Il Cho et al.   BRITISH JOURNAL OF CANCER

Primary Epstein-Barr virus infection

(2018) Samantha K. Dunmire et al.   JOURNAL OF CLINICAL VIROLOGY

EBV persistence without its EBNA3A and 3C oncogenes in vivo

(2018) Anita Murer et al.   PLoS Pathogens

Emergence of CD4+ and CD8+ Polyfunctional T Cell Responses Against Immunodominant Lytic and Latent EBV Antigens in Children With Primary EBV Infection

(2018) Janice K. P. Lam et al.   Frontiers in Microbiology

Epstein–Barr Virus and Cancer

(2018) Paul J. Farrell   Annual Review of Pathology-Mechanisms of Disease

Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1–Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice

(2018) Simon Danisch et al.   AMERICAN JOURNAL OF PATHOLOGY

Emerging Cellular Therapies for Cancer

(2018) Sonia Guedan et al.   Annual Review of Immunology

Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice

(2018) Dwain G. van Zyl et al.   PLoS Pathogens

Cognate HLA absence in trans diminishes human NK cell education

(2016) Vanessa Landtwing et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

(2016) Yew Ann Leong et al.   NATURE IMMUNOLOGY

Does persistent HIV replication explain continued lymphoma incidence in the era of effective antiretroviral therapy?

(2016) Jennifer Totonchy et al.   Current Opinion in Virology

Early T Cell Recognition of B Cells following Epstein-Barr Virus Infection: Identifying Potential Targets for Prophylactic Vaccination

(2016) Jill M. Brooks et al.   PLoS Pathogens

The Immunology of Epstein-Barr Virus–Induced Disease

(2015) Graham S. Taylor et al.   Annual Review of Immunology

Role of the 2B4 Receptor in CD8+T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components

(2015) Obinna Chijioke et al.   JOURNAL OF INFECTIOUS DISEASES

Long-term Outcome of Extranodal NK/T Cell Lymphoma Patients Treated With Postremission Therapy Using EBV LMP1 and LMP2a-specific CTLs

(2015) Seok-Goo Cho et al.   MOLECULAR THERAPY

Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma

(2015) Y. Zheng et al.   Cancer Immunology Research

Targeted Activation of Human Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative Disease

(2014) Zheng Xiang et al.   CANCER CELL

Virus and Autoantigen-Specific CD4+ T Cells Are Key Effectors in a SCID Mouse Model of EBV-Associated Post-Transplant Lymphoproliferative Disorders

(2014) Stefanie Linnerbauer et al.   PLoS Pathogens

Adoptive Transfer of EBV Specific CD8+ T Cell Clones Can Transiently Control EBV Infection in Humanized Mice

(2014) Olga Antsiferova et al.   PLoS Pathogens

Gammaherpesviruses and Lymphoproliferative Disorders

(2013) Ethel Cesarman   Annual Review of Pathology-Mechanisms of Disease

Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

(2013) C. R. Y. Cruz et al.   BLOOD

Human CD8+ memory and EBV-specific T cells show low alloreactivity in vitro and in CD34+ stem cell–engrafted NOD/SCID/IL-2Rγcnull mice

(2013) Simone Thomas et al.   EXPERIMENTAL HEMATOLOGY

Sustained Complete Responses in Patients With Lymphoma Receiving Autologous Cytotoxic T Lymphocytes Targeting Epstein-Barr Virus Latent Membrane Proteins

(2013) Catherine M. Bollard et al.   JOURNAL OF CLINICAL ONCOLOGY

A new cloning and expression system yields and validates TCRs from blood lymphocytes of patients with cancer within 10 days

(2013) Eiji Kobayashi et al.   NATURE MEDICINE

Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection

(2013) Obinna Chijioke et al.   Cell Reports

Cord Blood T Cells Retain Early Differentiation Phenotype Suitable for Immunotherapy After TCR Gene Transfer to Confer EBV Specificity

(2012) G. Frumento et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Effective Treatment of Metastatic Forms of Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma with a Novel Adenovirus-Based Adoptive Immunotherapy

(2012) C. Smith et al.   CANCER RESEARCH

Adoptive Transfer of Epstein-Barr Virus (EBV) Nuclear Antigen 1–Specific T Cells As Treatment for EBV Reactivation and Lymphoproliferative Disorders After Allogeneic Stem-Cell Transplantation

(2012) Vanya Icheva et al.   JOURNAL OF CLINICAL ONCOLOGY

Global burden of cancers attributable to infections in 2008: a review and synthetic analysis

(2012) Catherine de Martel et al.   LANCET ONCOLOGY

Characteristics of Early and Late PTLD Development in Pediatric Solid Organ Transplant Recipients

(2012) Tilmann Schober et al.   TRANSPLANTATION

Human MHC Class I-restricted high avidity CD4+T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

(2012) Shao-An Xue et al.   OncoImmunology

Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector

(2011) Dongchang Yang et al.   Clinical & Developmental Immunology

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

(2011) Frederik J Verweij et al.   EMBO JOURNAL

An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells

(2010) Pavel A. Nikitin et al.   Cell Host & Microbe

A New Model of Epstein-Barr Virus Infection Reveals an Important Role for Early Lytic Viral Protein Expression in the Development of Lymphomas

(2010) S.-D. Ma et al.   JOURNAL OF VIROLOGY

Infectious Mononucleosis

(2010) Katherine Luzuriaga et al.   NEW ENGLAND JOURNAL OF MEDICINE

EBV-Induced Human CD8+ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies

(2009) H. Yuling et al.   CANCER RESEARCH

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

(2009) Till Strowig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell–Mediated Control of Epstein‐Barr Virus Infection in Humanized Mice

(2009) Misako Yajima et al.   JOURNAL OF INFECTIOUS DISEASES

A review of human carcinogens—Part B: biological agents

(2009) Véronique Bouvard et al.   LANCET ONCOLOGY