miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1

Beta-arrestins operate an on/off control switch for focal adhesion kinase activity

(2020) Revu Ann Alexander et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Levels of Circulating miR‐122 are Associated with Weight Loss and Metabolic Syndrome

(2020) Anne Lundby Hess et al.   Obesity

Cardiomyocyte‐derived exosomal microRNA‐92a mediates post‐ischemic myofibroblast activation both in vitro and ex vivo

(2020) Xujun Wang et al.   ESC Heart Failure

No pleotropic effects of linagliptin on atherosclerotic plaques: Case closed

(2020) Mouaz H. Al-Mallah et al.   ATHEROSCLEROSIS

Terminating G-Protein Coupling: Structural Snapshots of GPCR-β-Arrestin Complexes

(2020) Madhu Chaturvedi et al.   CELL

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

(2020) Lauren M. Slosky et al.   CELL

MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes

(2020) Lena Eliasson et al.   DIABETES

Pervasive Small RNAs in Cardiometabolic Research: Great Potential Accompanied by Biological and Technical Barriers

(2020) Danielle L. Michell et al.   DIABETES

Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G protein–coupled receptors

(2020) Mithu Baidya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COVID-19-associated hyperviscosity: a link between inflammation and thrombophilia?

(2020) Cheryl L Maier et al.   LANCET

MiR-337-3p Promotes Adipocyte Browning by Inhibiting TWIST1

(2020) Indira G.C. Vonhögen et al.   Cells

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

(2019) Tiia A. Turunen et al.   Scientific Reports

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

(2019) Anthony H. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion

(2019) Marco B. Morelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNAs as Prognostic Markers in Acute Coronary Syndrome Patients—A Systematic Review

(2019) Jennifer Y. Barraclough et al.   Cells

Expression of miR-206 in human islets and its role in glucokinase regulation

(2018) Mugdha V. Joglekar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Targeting GLP-1 receptor trafficking to improve agonist efficacy

(2018) Ben Jones et al.   Nature Communications

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

(2018) Yi-Lynn Liang et al.   NATURE

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

(2018) Louis M. Luttrell et al.   Science Signaling

G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor

(2018) Minjung Choi et al.   Science Signaling

Exosomal microRNA: The revolutionary endogenous Innerspace nanotechnology

(2018) Gaetano Santulli   Science Translational Medicine

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility

(2018) Jihee Kim et al.   Skeletal Muscle

Crystal structure of the GLP-1 receptor bound to a peptide agonist

(2017) Ali Jazayeri et al.   NATURE

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

(2017) Gaojie Song et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

(2017) Rodrigo Carlessi et al.   Scientific Reports

Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells

(2017) Angela Lombardi et al.   Scientific Reports

Combined Analysis of Three Large Interventional Trials With Gliptins Indicates Increased Incidence of Acute Pancreatitis in Patients With Type 2 Diabetes

(2016) Ivan Tkáč et al.   DIABETES CARE

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

(2015) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

(2015) Mathieu Latreille et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function

(2015) Ashish Srivastava et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial oxidative stress promotes atrial fibrillation

(2015) Wenjun Xie et al.   Scientific Reports

Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison

(2015) Samalia Dabul et al.   Scientific Reports

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

(2015) Huanyu Xu et al.   Scientific Reports

Tyr Phosphatase-Mediated P-ERK Inhibition Suppresses Senescence in EIA + v-raf Transformed Cells, Which, Paradoxically, Are Apoptosis-Protected in a MEK-Dependent Manner

(2015) Stefania De Vitis et al.   NEOPLASIA

Role of non-coding RNAs in pancreatic beta-cell development and physiology

(2014) L. Eliasson et al.   Acta Physiologica

A selective microRNA-based strategy inhibits restenosis while preserving endothelial function

(2014) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)

(2014) Anja Sørensen et al.   Genes

Adrenal Signaling in Heart Failure

(2013) Gaetano Santulli   HYPERTENSION

The QKI-5 and QKI-6 RNA Binding Proteins Regulate the Expression of MicroRNA 7 in Glial Cells

(2013) Yunling Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Age-Related Impairment in Insulin Release: The Essential Role of  2-Adrenergic Receptor

(2012) G. Santulli et al.   DIABETES

Regulation of Pancreatic microRNA-7 Expression

(2012) Sharon Kredo-Russo et al.   Experimental Diabetes Research

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

(2012) Juris J. Meier   Nature Reviews Endocrinology

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice

(2011) Benjamin J. Lamont et al.   JOURNAL OF CLINICAL INVESTIGATION

GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells

(2009) Julie Quoyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic   cells

(2008) N. Sonoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative differential expression analysis reveals miR-7 as major islet microRNA

(2007) Valia Bravo-Egana et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS