mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells

EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology

(2019) Barbara Colella et al.   Cancers

Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion

(2019) Emily S. Bell et al.   Cell Reports

Current and emerging EGFR therapies for glioblastoma

(2018) Stefan Alexandru Artene et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

(2018) Zhenyi An et al.   ONCOGENE

Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking

(2018) William Critchley et al.   Cells

Autophagy induction impairs Wnt/β-catenin signalling through β-catenin relocalisation in glioblastoma cells

(2018) Barbara Colella et al.   CELLULAR SIGNALLING

Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking

(2017) Jane Fraser et al.   Essays in Biochemistry

mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery

(2017) Kristin Dauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EGFR odyssey – from activation to destruction in space and time

(2017) Jeroen Bakker et al.   JOURNAL OF CELL SCIENCE

Emerging functions of the EGFR in cancer

(2017) Sara Sigismund et al.   Molecular Oncology

Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis

(2017) Giusi Caldieri et al.   SCIENCE

Epidermal growth factor receptor in glioblastoma

(2017) Hongsheng Xu et al.   Oncology Letters

A phase I dose-escalation study of XL147 (SAR245408), a PI3K inhibitor administered orally to patients (pts) with advanced malignancies.

(2017) G. Edelman et al.   JOURNAL OF CLINICAL ONCOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

(2015) C. Larrue et al.   BLOOD

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(2015) Xiaojun Tan et al.   CELL

The effect of the size of fluorescent dextran on its endocytic pathway

(2015) Lei Li et al.   CELL BIOLOGY INTERNATIONAL

Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells

(2015) Myriam Catalano et al.   Molecular Oncology

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

(2013) H. Ebi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

Endocytosis of Receptor Tyrosine Kinases

(2013) L. K. Goh et al.   Cold Spring Harbor Perspectives in Biology

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling

(2012) Kristy J. Wilson et al.   GROWTH FACTORS

Src family kinases mediate epidermal growth factor receptor signaling from lipid rafts in breast cancer cells

(2011) Mary E. Irwin et al.   CANCER BIOLOGY & THERAPY

Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

(2011) G. Prasad et al.   NEURO-ONCOLOGY

Nuclear trafficking of the epidermal growth factor receptor family membrane proteins

(2010) Y-N Wang et al.   ONCOGENE

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

Epidermal Growth Factor Receptor Translocation to the Mitochondria

(2009) Michelle L. Demory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic EGFR Signaling Networks in Glioma

(2009) P. H. Huang et al.   Science Signaling

c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling

(2008) Mrudula Donepudi et al.   CELLULAR SIGNALLING

Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer

(2008) Kirstine Roepstorff et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Functional selectivity of EGF family peptide growth factors: Implications for cancer

(2008) Kristy J. Wilson et al.   PHARMACOLOGY & THERAPEUTICS