Article
Pharmacology & Pharmacy
Jun Huang, Zhuang Li, Yunwei Hu, Guanyu Chen, Zuoyi Li, Yanyan Xie, Haixiang Huang, Wenru Su, Xiaoqing Chen, Dan Liang
Summary: Azithromycin alleviates experimental autoimmune uveitis (EAU) in mice by regulating the balance between T effector cells (Teff) and T regulatory cells (Treg) through the mTOR signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Ruo-Nan Shao, Kun-Hao Bai, Qian-Qian Huang, Si-Liang Chen, Xin Huang, Yu-Jun Dai
Summary: In this study, a risk model based on CRGs was constructed and five of these CRGs were found to be associated with prognosis in HCC. High-risk patients had shorter overall survival times. Functional analysis revealed the presence of Treg cells in high-risk patients, indicating a suppressed immune state. Furthermore, certain immunotherapies were found to potentially benefit high-risk patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Zhizhong Ren, Yuanxun Yue, Yuewei Zhang, Jiahong Dong, Ying Liu, Xiaowei Yang, Xin Lin, Xueqiang Zhao, Zhanqi Wei, Yu Zheng, Tianxiao Wang
Summary: The study demonstrated that m-TACE has a positive regulatory effect on the anticancer immune function of HCC patients and can be used in combination with immune adjuvant therapies to enhance the efficacy of HCC treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Li Wu, Fu-Rong Yang, Mu-Lan Xing, Sheng-Feng Lu, Hong-Lin Chen, Qiao-Wei Yang, Yu-Ting Zhang, Yin Lu, Yan Huang
Summary: This study investigates the effects of Dahuang Zhechong pill (DHZCP) on hepatocellular carcinoma (HCC) by regulating Treg/Th1 balance. The findings suggest that DHZCP inhibits the differentiation of Tregs, reverses the balance of Treg/Th1, and improves tumor immunity. Furthermore, the study reveals the multi-target mechanism and material basis of DHZCP.
Article
Immunology
Lisha Zhou, Meiling Wang, Hanrui Guo, Jun Hou, Yingna Zhang, Man Li, Xiangwei Wu, Xueling Chen, Lianghai Wang
Summary: The role of TREM2 signaling in the tumor microenvironment of hepatocellular carcinoma (HCC) was investigated. TREM2 was predominantly expressed by a macrophage subpopulation enriched in tumor tissues and correlated with high infiltrating macrophage abundance and poor prognosis. TREM2(+) LAM-like cells recruited suppressive Treg cells, facilitating microenvironment remodeling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Eslam E. Abd El-Fattah, Amr Y. Zakaria
Summary: This article investigates the mechanisms of action of metformin (an antidiabetic medication) on hepatocellular carcinoma (HCC), focusing on the modulation of the HCC immune microenvironment and changes in immune mediators. Metformin corrects pathological changes in HCC by affecting proliferation, apoptosis, and angiogenesis, leading to improved immune fitness and prognosis. It acts as a robust antineoplastic agent with multiple mechanisms of action, particularly for individuals with diabetes and HCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Jing Huo, Taibin Liu, Fenghua Li, Xinfeng Song, Xiuli Hou
Summary: This study found that in patients with vitiligo, the proportions of CD4(+) T cells, Treg cells, and T helper 1 (Th1) cells were decreased, while Teff cells (Th17 and Th22 cells) were increased. Additionally, miR-21-5p may protect melanocytes by targeting STAT3 and regulating Treg/Teff balance.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Changlin Zhao, Xianlin Wu, Jia Chen, Guoqiang Qian
Summary: The therapeutic effects of IL-21 and IFN-gamma inducing the formation of CD4(+)CXCR5(+)CD57(+)T cells on liver cancer were evaluated in this study. The increase in CD4(+)CXCR5(+)CD57(+)T cells and the elevated expression of IL-21 and IFN-gamma were associated with prolonged survival in liver cancer patients. HBV infection led to a decrease in CD4(+)CXCR5(+)CD57(+)T cells and chronic inflammation.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Katherine A. McGlynn, Jessica L. Petrick, Hashem B. El-Serag
Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), is a major global health concern. While HBV and HCV remain important risk factors for HCC, efforts in vaccination and treatment are showing promise. However, the increasing prevalence of metabolic risk factors like obesity and diabetes, as well as other factors like excessive alcohol consumption, present ongoing challenges in the prevention of liver cancer.
Article
Multidisciplinary Sciences
Belete Tessema, Girma Gonfa, Sintayehu Mekuria Hailegiorgis, Venkatesa Prabhu Sundramurthy
Summary: The utilization of biomass is important for both economic and environmental reasons. In order to use biomass for industrial purposes and reduce its impact on the environment, it is necessary to understand its composition. This study analyzed the proximate and chemical composition of Teff straw from four different varieties and found that it can be used for the production of silica.
Article
Oncology
Lin Zhou, Jing Wang, Shao-cheng Lyu, Li-chao Pan, Xian-jie Shi, Guo-sheng Du, Qiang He
Summary: The study found that PD-L1(+)NEUT, NLR, and Foxp3(+)Treg are independent risk factors for diagnosis and prognosis, associated with survival benefits.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Gastroenterology & Hepatology
Maria Reig, Giuseppe Cabibbo
Summary: The potential impact of DAAs in BCLC-B/C stage patients with HCC is understudied, as HCC patients have been excluded from DAA trials. The decision on using DAAs should be made based on individual patient profiles.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Lorenza Rimassa, Richard S. Finn, Bruno Sangro
Summary: Single-agent immune checkpoint inhibitors (ICIs) have limited efficacy in advanced hepatocellular carcinoma (HCC) patients, and approximately 30% of patients show intrinsic resistance to ICIs. Therefore, researchers are exploring combination therapies, such as anti-angiogenic agents and other ICIs. Some trials have shown promising results and potential for clinical application. However, there are still many unanswered questions that require further research.
JOURNAL OF HEPATOLOGY
(2023)
Review
Oncology
Tian-Run Lv, Hai-Jie Hu, Parbatraj Regmi, Fei Liu, Fu-Yu Li
Summary: Sarcomatoid hepatocellular carcinoma (SHCC) is a rare subtype of primary liver malignancies. Compared to conventional hepatocellular carcinoma (HCC), SHCC has worse prognosis and exhibits more aggressive behavior.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xudong Zhang, Jincheng Wang, Baoqiang Wu, Tao Li, Lei Jin, Yong Wu, Peng Gao, Zhen Zhang, Xihu Qin, Chunfu Zhu
Summary: This study developed a nomogram-based model to evaluate the neoplastic potential of patients with gallbladder polyps. The results showed that the model had better discrimination for neoplastic GBPs and provided the greatest clinical benefit compared to other methods.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lu Liu, Xianfeng Cheng, Hui Yang, Senlin Lian, Yuegen Jiang, Jinhua Liang, Xiao Chen, Suo Mo, Yu Shi, Sishu Zhao, Jianyong Li, Runqiu Jiang, Dong-Hua Yang, Yujie Wu
Summary: BCL-2 expression in T cells of CLL patients is associated with immunosuppression through promoting regulatory T cell abundance and cytotoxic T lymphocyte exhaustion.
Article
Gastroenterology & Hepatology
Xudong Zhang, Jincheng Wang, Baoqiang Wu, Tao Li, Lei Jin, Yong Wu, Peng Gao, Zhen Zhang, Xihu Qin, Chunfu Zhu
Summary: We established an accurate neoplastic predictive model for gallbladder polyps (GBPs) using clinical data and verified the effectiveness of radiomics in predicting malignancy. The model showed good discrimination ability and the use of radiomics may help avoid unnecessary surgery.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yuan Zong, Yijing Liu, Chenxiao Xue, Boshu Li, Xiangyang Li, Yanpeng Wang, Ji Li, Guanwen Liu, Xingxu Huang, Xiaofeng Cao, Caixia Gao
Summary: In this study, we have improved the editing efficiency of prime editing by engineering the structure of the prime editor and combining it with specific guide RNAs. The optimized prime editor showed significantly increased editing efficiency in plant cells, and when combined with engineered guide RNAs, it resulted in the generation of herbicide-tolerant rice plants.
NATURE BIOTECHNOLOGY
(2022)
Review
Biology
Guanglei Li, Xiangyang Li, Songkuan Zhuang, Liren Wang, Yifan Zhu, Yangcan Chen, Wen Sun, Zeguang Wu, Zhuo Zhou, Jia Chen, Xingxu Huang, Jin Wang, Dali Li, Wei Li, Haoyi Wang, Wensheng Wei
Summary: The steady progress in genome editing has provided enormous opportunities for biomedical research and human health. It has yielded significant advances in studying human diseases and offers unprecedented capabilities in clinical diagnosis, prevention, and treatment.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Editorial Material
Genetics & Heredity
Xiangyang Li, Xingxu Huang
Summary: The prime editing system is not only capable of small insertions and deletions, but it can also be modified to efficiently and precisely delete large DNA fragments.
TRENDS IN GENETICS
(2022)
Letter
Cell Biology
Xiangyang Li, Xin Wang, Wenjun Sun, Shisheng Huang, Mingtian Zhong, Yuan Yao, Quanjiang Ji, Xingxu Huang
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yafeng Wang, Guiquan Zhang, Qingzhou Meng, Shisheng Huang, Panpan Guo, Qibin Leng, Lingyun Sun, Geng Liu, Xingxu Huang, Jianghuai Liu
Summary: Reinvigoration of antitumor immunity through gene circuit-based tumor-localized immune activation using CRISPRa is explored in this study. By assembling circuits with oncogenic TF-driven CRISPRa effector and p53-inducible off-switch, an AND-NOT logic is executed for accurate tumor targeting. The optimized circuit enables specific tumor recognition and immune rewiring in vivo.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yan Cao, Zongxing He, Qimingxing Chen, Xiaoyan He, Lili Su, Wenxia Yu, Mingming Zhang, Huiying Yang, Xingxu Huang, Jianfeng Li
Summary: A highly efficient lung-specific mRNA delivery platform named five-element nanoparticles (FNPs) was developed using a combination of helper-polymer poly(beta-amino esters) (PBAEs) and DOTAP. The FNPs exhibited high stability due to increased charge repulsion and binding force. Structure-activity relationship (SAR) analysis showed that specific PBAEs with certain structural features exhibited higher delivery efficiency. Lyophilized FNP formulations showed long-term stability at low temperatures. Overall, this novel delivery platform is important for advancing mRNA-based therapies for lung-associated diseases.
Article
Multidisciplinary Sciences
Xuelong Yao, Zongyang Lu, Zhanying Feng, Lei Gao, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu, Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang, Xiaoqun Wang, Jiang Liu
Summary: This study investigates the differences in the epigenetic regulation of brain development between primates and identifies regulatory elements that may be related to cognitive capacity.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Yuyu Huang, Dekun Gao, Yan Wu, Lianhua Sun, Jianyong Chen, Junmin Chen, Xingxu Huang, Jun Yang, Shuna Li
Summary: This study investigated the potential mechanisms of YTHDF1 in cisplatin-induced damage in sensory hair cells. The authors found that the overexpression of YTHDF1 alleviated the injury induced by cisplatin, while its deficiency exacerbated the damage. Additionally, YTHDF1 was found to promote the activation of autophagy by enhancing the translation of the autophagy-related gene ATG14. Overall, YTHDF1 could be a potential target for ameliorating drug-induced sensory hair cell damage through m6A modification.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Ying Xue, Min Li, Jie Hu, Yuanlin Song, Wei Guo, Changhong Miao, Di Ge, Yingyong Hou, Xuefei Wang, Xingxu Huang, Tianshu Liu, Xiaoping Zhang, Qihong Huang
Summary: Through analysis of genomic data, it was discovered that Ca(v)2.2 plays a significant role in breast cancer metastasis and promotes cell migration, invasion, and metastasis. Ca(v)2.2 facilitates invadopodia formation and extracellular matrix degradation by stabilizing the invadopodia component cortactin. Additionally, Ca(v)2.2 mediates these functions by regulating the expression of the deubiquitinating enzyme USP43.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Zhenwu Zhang, Wanyu Tao, Shisheng Huang, Wenjun Sun, Yue Wang, Wen Jiang, Xingxu Huang, Chao-Po Lin
Summary: Genome editing in pluripotent stem cells using CRISPR technology holds promise for therapeutic applications, but it can cause DNA deletions, rearrangements, and mutations. Adenine base editors have been proposed as an alternative, but their off-target effects limit their applications. This study tested different methods to reduce off-target effects and identified the best editor, CE-8e-dV, which showed no off-target effects in pluripotent stem cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Gastroenterology & Hepatology
Suyavaran Arumugam, Binghua Li, Sri Lakshmi Tejaswi Boodapati, Michael H. Nathanson, Beicheng Sun, Xinshou Ouyang, Wajahat Z. Mehal
Summary: TGF-beta induces HSC transdifferentiation by releasing mitochondrial DNA and activating the cGAS-STING-IRF3 pathway.
Article
Biochemistry & Molecular Biology
Ziwen Zheng, Guo Li, Chong Cui, Fang Wang, Xiaohan Wang, Zhijiao Xu, Huiping Guo, Yuxin Chen, Honghai Tang, Daqi Wang, Mingqian Huang, Zheng-Yi Chen, Xingxu Huang, Huawei Li, Geng-Lin Li, Xiaoxiang Hu, Yilai Shu
Summary: The CRISPR/CasRx editing system was used to specifically and precisely reduce the expression of target gene in a mouse model of autosomal-dominant hearing loss, leading to improved hearing performance.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
