Engineered biomaterials for in situ tissue regeneration

Inorganic Biomaterials for Regenerative Medicine

(2020) Anna M. Brokesh et al.   ACS Applied Materials & Interfaces

Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels

(2019) Claudia Loebel et al.   NATURE MATERIALS

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

(2019) Kalina Paunovska et al.   ADVANCED MATERIALS

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

(2019) Lauren M. Cross et al.   ACS Applied Materials & Interfaces

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

(2019) Guang Yang et al.   ACS Nano

Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing

(2019) Jiah Shin Chin et al.   Acta Biomaterialia

2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

(2019) Akhilesh K. Gaharwar et al.   ADVANCED MATERIALS

Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice

(2019) Elya A. Shamskhou et al.   BIOMATERIALS

Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials

(2019) Jared A. Shadish et al.   NATURE MATERIALS

Biomaterial Surface Hydrophobicity-Mediated Serum Protein Adsorption and Immune Responses

(2019) Rahul M. Visalakshan et al.   ACS Applied Materials & Interfaces

Logic‐Based Delivery of Site‐Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials

(2019) Prathamesh Milind Gawade et al.   ADVANCED MATERIALS

Therapeutic mRNA delivery to leukocytes

(2019) Yasmin Granot-Matok et al.   JOURNAL OF CONTROLLED RELEASE

3D bioprinting of collagen to rebuild components of the human heart

(2019) A. Lee et al.   SCIENCE

Non-viral delivery of chemically modified mRNA to the retina: Subretinal versus intravitreal administration

(2019) Joke Devoldere et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces

(2019) Weiyang Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell mass cytometry reveals in vivo immunological response to surgical biomaterials

(2019) Haoyu Wu et al.   Applied Materials Today

Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies

(2019) David Chimene et al.   ADVANCED MATERIALS

Nanoengineered Ionic–Covalent Entanglement (NICE) Bioinks for 3D Bioprinting

(2018) David Chimene et al.   ACS Applied Materials & Interfaces

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

(2018) Ying-Li Luo et al.   ACS Nano

Nanoengineered injectable hydrogels for wound healing application

(2018) Giriraj Lokhande et al.   Acta Biomaterialia

Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration

(2018) Yan Huang et al.   Acta Biomaterialia

RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects

(2018) Minh K. Nguyen et al.   Acta Biomaterialia

An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering

(2018) Can Zhang et al.   Acta Biomaterialia

In situ forming injectable hydrogels for drug delivery and wound repair

(2018) Robert Dimatteo et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymeric microneedles for transdermal protein delivery

(2018) Yanqi Ye et al.   ADVANCED DRUG DELIVERY REVIEWS

Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting

(2018) Amir K. Miri et al.   ADVANCED MATERIALS

Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy

(2018) Peng Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke

(2018) Lina R. Nih et al.   NATURE MATERIALS

Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates

(2018) James K. Carrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold in the treatment of large bone defects

(2018) Linyang Chu et al.   Journal of Materials Chemistry B

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

Photoresponsive biomaterials for targeted drug delivery and 4D cell culture

(2018) Emily R. Ruskowitz et al.   Nature Reviews Materials

Injectable Supramolecular Hydrogel/Microgel Composites for Therapeutic Delivery

(2018) Minna H. Chen et al.   MACROMOLECULAR BIOSCIENCE

Single-cell genomics to guide human stem cell and tissue engineering

(2018) J. Gray Camp et al.   NATURE METHODS

mRNA-Based Genetic Reprogramming

(2018) Luigi Warren et al.   MOLECULAR THERAPY

Author Correction: Bi-directional cell-pericellular matrix interactions direct stem cell fate

(2018) Silvia A. Ferreira et al.   Nature Communications

Cardiac cell–integrated microneedle patch for treating myocardial infarction

(2018) Junnan Tang et al.   Science Advances

Divergent immune responses to synthetic and biological scaffolds

(2018) Kaitlyn Sadtler et al.   BIOMATERIALS

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability

(2017) Shuoran Li et al.   NATURE MATERIALS

Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing

(2017) Claudia Loebel et al.   Nature Protocols

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

(2017) Kunwoo Lee et al.   Nature Biomedical Engineering

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties

(2016) Yi Wen et al.   ACS Nano

Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates

(2016) Yun Wang et al.   Acta Biomaterialia

Rapid Continuous Multimaterial Extrusion Bioprinting

(2016) Wanjun Liu et al.   ADVANCED MATERIALS

A Generalizable Strategy for the 3D Bioprinting of Hydrogels from Nonviscous Photo-crosslinkable Inks

(2016) Liliang Ouyang et al.   ADVANCED MATERIALS

Modulation of Immune Responses by Particulate Materials

(2016) Filipa Lebre et al.   ADVANCED MATERIALS

Advanced Bioinks for 3D Printing: A Materials Science Perspective

(2016) David Chimene et al.   ANNALS OF BIOMEDICAL ENGINEERING

Epigenetic Therapeutics: A New Weapon in the War Against Cancer

(2016) Nita Ahuja et al.   Annual Review of Medicine

Bone induction at physiological doses of BMP through localization by clay nanoparticle gels

(2016) D.M.R. Gibbs et al.   BIOMATERIALS

Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation

(2016) Fraz Anjum et al.   BIOMATERIALS

In Vivo Cellular Reprogramming: The Next Generation

(2016) Deepak Srivastava et al.   CELL

Nanotechnology for protein delivery: Overview and perspectives

(2016) Mikyung Yu et al.   JOURNAL OF CONTROLLED RELEASE

Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration

(2016) Renae Waters et al.   Nanoscale

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

Immune modulation by MANF promotes tissue repair and regenerative success in the retina

(2016) J. Neves et al.   SCIENCE

Immunomodulation and Mobilization of Progenitor Cells by Extracellular Matrix Bioscaffolds for Volumetric Muscle Loss Treatment

(2016) Jenna L. Dziki et al.   TISSUE ENGINEERING PART A

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

(2016) Ajaykumar Vishwakarma et al.   TRENDS IN BIOTECHNOLOGY

Design principles for therapeutic angiogenic materials

(2016) Priscilla S. Briquez et al.   Nature Reviews Materials

3D Scaffolds with Different Stiffness but the Same Microstructure for Bone Tissue Engineering

(2015) Guobao Chen et al.   ACS Applied Materials & Interfaces

Inducing Stem Cell Myogenesis Using NanoScript

(2015) Sahishnu Patel et al.   ACS Nano

Bioactive Nanoengineered Hydrogels for Bone Tissue Engineering: A Growth-Factor-Free Approach

(2015) Janet R. Xavier et al.   ACS Nano

Mechanically Stiff Nanocomposite Hydrogels at Ultralow Nanoparticle Content

(2015) Manish K. Jaiswal et al.   ACS Nano

3D surface topology guides stem cell adhesion and differentiation

(2015) Priyalakshmi Viswanathan et al.   BIOMATERIALS

Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues

(2015) Constant Morez et al.   BIOMATERIALS

Nano-hydroxyapatite modulates osteoblast lineage commitment by stimulation of DNA methylation and regulation of gene expression

(2015) Shin-Woo Ha et al.   BIOMATERIALS

Shape and size-dependent immune response to antigen-carrying nanoparticles

(2015) Sunny Kumar et al.   JOURNAL OF CONTROLLED RELEASE

Stiffness of Hydrogels Regulates Cellular Reprogramming Efficiency Through Mesenchymal-to-Epithelial Transition and Stemness Markers 

(2015) Bogyu Choi et al.   MACROMOLECULAR BIOSCIENCE

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

In vivo delivery of transcription factors with multifunctional oligonucleotides

(2015) Kunwoo Lee et al.   NATURE MATERIALS

Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks

(2015) Donald R. Griffin et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Self-assembled hydrogels utilizing polymer–nanoparticle interactions

(2015) Eric A. Appel et al.   Nature Communications

3D Printing of Scaffolds for Tissue Regeneration Applications

(2015) Anh-Vu Do et al.   Advanced Healthcare Materials

Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels

(2015) T. J. Hinton et al.   Science Advances

NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation

(2014) Sahishnu Patel et al.   ACS Nano

Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage

(2014) Akhilesh K. Gaharwar et al.   ACS Nano

Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells

(2014) Anne Schellenberg et al.   BIOMATERIALS

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

(2014) Pouria Moshayedi et al.   BIOMATERIALS

Materials as stem cell regulators

(2014) William L. Murphy et al.   NATURE MATERIALS

Nanoengineered Particles for Enhanced Intra-Articular Retention and Delivery of Proteins

(2014) Ankur Singh et al.   Advanced Healthcare Materials

Porous Implants Modulate Healing and Induce Shifts in Local Macrophage Polarization in the Foreign Body Reaction

(2013) Eric M. Sussman et al.   ANNALS OF BIOMEDICAL ENGINEERING

The promotion of bone regeneration through positive regulation of angiogenic–osteogenic coupling using microRNA-26a

(2013) Yan Li et al.   BIOMATERIALS

Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway

(2013) Zetao Chen et al.   BIOMATERIALS

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

(2013) Julia Ladewig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Nanotopographical Cues Augment Mesenchymal Differentiation of Human Embryonic Stem Cells

(2013) Emmajayne Kingham et al.   Small

Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells

(2012) Weiqiang Chen et al.   ACS Nano

Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor

(2012) Anuradha Biswas et al.   BIOMATERIALS

Osteogenesis and angiogenesis induced by porous β-CaSiO3/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways

(2012) Chen Wang et al.   BIOMATERIALS

Improvement in the delivery system of bone morphogenetic protein-2: a new approach to promote bone formation

(2012) Quan Zhang et al.   Biomedical Materials

Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012

(2012) Anna K. Blakney et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Clay Gels For the Delivery of Regenerative Microenvironments

(2011) Jonathan I. Dawson et al.   ADVANCED MATERIALS

Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation

(2011) Tomoya Manaka et al.   BIOMATERIALS

A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics

(2011) Alexander Hoppe et al.   BIOMATERIALS

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

(2011) Cole A. DeForest et al.   Nature Chemistry

Mechanical regulation of vascular growth and tissue regeneration in vivo

(2011) J. D. Boerckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Additive manufacturing of tissues and organs

(2011) Ferry P.W. Melchels et al.   PROGRESS IN POLYMER SCIENCE

Trends in the Use of Bone Morphogenetic Protein as a Substitute to Autologous Iliac Crest Bone Grafting for Spinal Fusion Procedures in the United States

(2011) Shivanand P. Lad et al.   SPINE

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned

(2011) Eugene J. Carragee et al.   Spine Journal

Rapid Uptake of Gold Nanorods by Primary Human Blood Phagocytes and Immunomodulatory Effects of Surface Chemistry

(2010) Matthias Bartneck et al.   ACS Nano

Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium

(2010) S. Khoshniat et al.   BONE

Strategies for the intracellular delivery of nanoparticles

(2010) Leo Y. T. Chou et al.   CHEMICAL SOCIETY REVIEWS

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Off-Label Use of Bone Morphogenetic Proteins in the United States Using Administrative Data

(2010) Kevin L. Ong et al.   SPINE

Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component

(2009) Bryan N. Brown et al.   BIOMATERIALS

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

(2009) Evelyn K.F. Yim et al.   BIOMATERIALS

Intrinsic extracellular matrix properties regulate stem cell differentiation

(2009) Gwendolen C. Reilly et al.   JOURNAL OF BIOMECHANICS

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides

(2009) S. Gallorini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

(2008) Mikaël M. Martino et al.   BIOMATERIALS

Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs

(2008) Simon Storgård Jensen et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Transdermal drug delivery

(2008) Mark R Prausnitz et al.   NATURE BIOTECHNOLOGY