Article
Clinical Neurology
Edward M. Reece, Matthew J. Davis, Ryan D. Wagner, Amjed Abu-Ghname, Alex Cruz, Geoffrey Kaung, Terence Verla, Sebastian Winocour, Alexander E. Ropper
Summary: Vascularized posterior iliac crest bone graft, harvested from the same incision used for thoracolumbar spinal fusion, can cover recipient sites in the posterolateral bony spinal gutters from T12 to the sacrum. Utilizing Indocyanine green (ICG) angiography can ensure the vascularity of the bone graft prior to arthrodesis, reducing operative time and bleeding compared to free flap procedures.
OPERATIVE NEUROSURGERY
(2021)
Article
Clinical Neurology
Woojin Cho, Adam Nessim, Ariella Gartenberg, Richard Sekerak, Sam Brill, Jayson Lian, Karen Sperling, Dong-Gune Chang
Summary: This retrospective cohort study aimed to investigate the correlation between race and the ratio of cancellous to total bone at the iliac crest in American white and black patients. The results showed that American black patients had a lower mean cancellous bone ratio compared to American white patients, suggesting that alternative graft options should be considered for this population in fusion surgeries.
CLINICAL SPINE SURGERY
(2022)
Article
Clinical Neurology
Robert F. McLain, Fernando Techy
Summary: The study aimed to review surgical technique for a trephine graft harvest technique and assess perioperative complications/pain, long-term outcome, and patient satisfaction. The results showed that trephine graft harvest minimized complications and pain, and patients were satisfied with the long-term outcome.
Article
Clinical Neurology
Jeremy A. Lombardo, Nick Russell, Jiawei He, Michael J. Larson, William R. Walsh, Gregory M. Mundis Jr, Frank Vizesi
Summary: This study aimed to assess the cellular contribution of autograft to spinal fusion and determine the effects of intraoperative storage conditions on fusion. The results showed that the cellular component of autograft is important for spinal fusion, with adherent graft cells being more crucial in the rabbit model. Furthermore, the use of saline for storage maintained cellular viability and fusion performance.
Article
Orthopedics
Lukas Ernstbrunner, Torsten Pastor, Manuel Waltenspul, Christian Gerber, Karl Wieser
Summary: The study evaluated factors associated with success or failure of using ICBG to restore shoulder stability after Latarjet failure. Salvage ICBG procedures failed in 7 out of 16 patients, with success typically seen in patients with clear graft-related factors from the initial Latarjet procedure. Patients with unclear instability symptoms, subscapularis insufficiency, inferior subluxation, uncontrolled seizures, or psychological disorders may not be suitable candidates for salvage ICBG, highlighting the importance of careful patient selection for both the initial Latarjet procedure and salvage ICBG.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Review
Clinical Neurology
Aoife Gordon, Fiona Newsome, Daniel P. Ahern, Jake M. Mcdonnell, Grainne Cunniffe, Joseph S. Butler
Summary: This systematic review compared grafts with additional cellular supplementation to iliac crest bone graft (ICBG) for spinal arthrodesis. The study found that cell-based therapy is non-inferior to ICBG in terms of fusion rates and clinical outcomes, offering a promising alternative with reduced morbidity to patients.
EUROPEAN SPINE JOURNAL
(2023)
Review
Critical Care Medicine
Bryan J. M. van de Wall, Frank J. P. Beeres, Ingmar F. Rompen, Bjoern C. Link, Reto Babst, Carsten Schoeneberg, Christian Michelitsch, Sven Nebelung, Hans-Christoph Pape, Boyko Gueorguiev, Matthias Knobe
Summary: The Reamer-Irrigator-Aspirator (RIA) technique appears to have lower risk for chronic pain and infection at the donor site compared to iliac crest bone graft harvesting. However, iliac crest harvesting carries the risk of nerve injury and scar numbness. Both techniques seem to have similar healing potentials at the implantation site.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Orthopedics
Sanjit R. Konda, Connor P. Littlefield, Kurtis D. Carlock, Abhishek Ganta, Philipp Leucht, Kenneth A. Egol
Summary: Autogenous iliac crest bone grafting remains the gold standard for the treatment of persistent tibial nonunions, with a high union rate of 97.1% achieved at a mean time of 7.8 months postoperatively. Surgical approach did not significantly impact time to union, indicating the efficacy of ICBG regardless of approach.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Surgery
Humberto Fernandez-Olarte, Andres Gomez-Delgado, Juan P. Lopez, Maria P. Orjuela
Summary: The objective of this article is to propose a technique for mandibular reconstructions, utilizing corticotomies to lengthen smaller anterior iliac crest grafts. This method has been successfully performed in 5 patients requiring reconstruction after partial mandibulectomy due to pathology.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Orthopedics
Xin Chen, Kai Chen, Yuxi Su
Summary: Comparing the effects of inner side and two-sided approaches for iliac crest bone harvesting, it was found that exposing only the inner side can promote faster healing of bone defects post-surgery, suggesting the need to protect the outer side of the ilium during surgery.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jinhui Shi, Xuesong Zhu, Huilin Yang, Weimin Jiang
Summary: This study compared the use of low-dose rhBMP-2 and iliac crest autographs in ACDF and investigated whether rhBMP-2 can reduce the incidence and severity of local complications. The results showed that adverse events associated with low-dose rhBMP-2 for one-and two-level ACDF are rare. It is recommended to place the rhBMP-2 carrier in the center of the interbody fusion cage and cover it bilaterally with excised local osteophytes.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Clinical Neurology
Mohammed A. Munim, Elyse Berlinberg, Vincent P. Federico, Michael T. Nolte, Michael Prabhu, Hanna Pawlowski, Karan S. Patel, Matthew W. Colman
Summary: This study used retrospective cohort analysis to investigate the utilization of rhBMP-2 in spinal tumor surgery and its association with postoperative complications, revisions, and carcinogenicity. The results showed that patients who underwent fusion with rhBMP-2 had significantly increased rates of surgical site and systemic infections. However, there were no significant differences in survival, implant removal, revision rates, or new cancer diagnoses.
GLOBAL SPINE JOURNAL
(2023)
Review
Orthopedics
Francesco Oliva, Filippo Migliorini, Francesco Cuozzo, Ernesto Torsiello, Frank Hildebrand, Nicola Maffulli
Summary: This meta-analysis found that compared to the traditional ICBG, using RIA for bone defect treatment can reduce postoperative site pain and infections, as well as decrease the incidence of adverse events. However, the ICBG group had a higher bone union rate.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2021)
Article
Surgery
Zhi-Hui Liang, Yue-Hui Zhang, Hai-Tao Liu, Qiu-Qi Zhang, Jia Song, Jiang Shao
Summary: This study compared the clinical outcomes of structural autografts from the occipital bone or iliac crest in pediatric patients. The results showed that occipital bone grafts had advantages over iliac bone grafts in terms of operation time, blood loss, and length of hospitalization, with a lower risk of complications.
FRONTIERS IN SURGERY
(2023)
Article
Clinical Neurology
Vijay Letchuman, Leonel Ampie, Winward Choy, Joseph D. DiDomenico, Hasan R. Syed, Avery L. Buchholz
Summary: Pediatric spinal fusions have high nonunion rates, leading to the development of various bone grafts and biologics to promote bone formation and fusion. The current gold-standard bone graft is autologous bone, but it comes with postoperative pain and morbidity. Other bone graft substitutes and biologics require more research specific to the pediatric population.
NEUROSURGICAL FOCUS
(2021)
Article
Oncology
Jay K. Nathan, Amanda L. Brezzell, Michelle M. Kim, Denise Leung, D. Andrew Wilkinson, Shawn L. Hervey-Jumper
JOURNAL OF NEURO-ONCOLOGY
(2017)
Article
Computer Science, Information Systems
Jay K. Nathan, Jenevra Foley, Tiffany Hoang, Jim Hiner, Stephanie Brooks, Julian L. Gendreau, William J. Meurer, Aditya S. Pandey, Eric E. Adelman
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2018)
Review
Clinical Neurology
Omar Choudhri, Abdullah H. Feroze, Jay Nathan, Samuel Cheshier, Raphael Guzman
CHILDS NERVOUS SYSTEM
(2014)
Article
Clinical Neurology
Michael E. Ivan, Jay K. Nathan, Geoffery T. Manley, Michael C. Huang
JOURNAL OF CLINICAL NEUROSCIENCE
(2013)
Article
Clinical Neurology
Kaisorn L. Chaichana, Courtney Pendleton, Lola Chambless, Joaquin Camara-Quintana, Jay K. Nathan, Laila Hassam-Malani, Gordon Li, Griffith R. Harsh, Reid C. Thompson, Michael Lim, Alfredo Quinones-Hinojos
JOURNAL OF CLINICAL NEUROSCIENCE
(2013)
Article
Immunology
Penelope M. Drake, Jay K. Nathan, Christina M. Stock, Pamela V. Chang, Marcus O. Muench, Daisuke Nakata, J. Rachel Reader, Phung Gip, Kevin P. K. Golden, Birgit Weinhold, Rita Gerardy-Schahn, Frederic A. Troy, Carolyn R. Bertozzit
JOURNAL OF IMMUNOLOGY
(2008)
Article
Medicine, Research & Experimental
Shivanand P. Lad, Paul S. Kalanithi, Robert T. Arrigo, Chirag G. Patil, Jay K. Nathan, Maxwell Boakye, Jaimie M. Henderson
Article
Clinical Neurology
Shivanand P. Lad, Jay K. Nathan, Ryan D. Schubert, Maxwell Boakye
Article
Multidisciplinary Sciences
Penelope M. Drake, Christina M. Stock, Jay K. Nathan, Phung Gip, Kevin P. K. Golden, Birgit Weinhold, Rita Gerardy-Schahn, Carolyn R. Bertozzi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Clinical Neurology
Robert H. Andres, Raymond Choi, Arjun V. Pendharkar, Xavier Gaeta, Nancy Wang, Jaya K. Nathan, Joshua Y. Chua, Star W. Lee, Theo D. Palmer, Gary K. Steinberg, Raphael Guzman
Article
Clinical Neurology
Jay K. Nathan, Bridger M. Rodoni, Jacob R. Joseph, Brandon W. Smith, Paul Park
OPERATIVE NEUROSURGERY
(2020)
Article
Clinical Neurology
Timothy J. Yee, Brandon W. Smith, Jacob R. Joseph, Yamaan S. Saadeh, Jay K. Nathan, Elyne N. Kahn, Siri S. Khalsa, Kelsey J. Fearer, Michael J. Kirsch, David R. Nerenz, Victor Chang, Jason M. Schwalb, Muwaffak M. Abdulhak, Paul Park
JOURNAL OF NEUROSURGERY-SPINE
(2019)
Article
Clinical Neurology
Harsh Wadhwa, Jigyasa Sharma, Kunal Varshneya, Parastou Fatemi, Jay Nathan, Zachary A. Medress, Martin N. Stienen, John K. Ratliff, Anand Veeravagu
Summary: This retrospective study reviewed readmission and reoperation rates for patients who had undergone ACDF or laminoplasty for multilevel CSM from a national administrative claims database. Results showed higher postoperative complication rates, longer length of stay, and higher readmission rates in the laminoplasty group, as well as higher hospital and total payments.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Kunal Varshneya, Zachary A. Medress, Martin N. Stienen, Jay Nathan, Allen Ho, Arjun V. Pendharkar, Sheri Loo, Jessica Aikin, Gordon Li, Atman Desai, John K. Ratliff, Anand Veeravagu
Summary: This retrospective cohort study analyzed postoperative complications, quality outcomes, and costs of surgical approaches for adult cervical deformity (ACD). The study found that posterior fusion surgery for ACD had higher complication rates, readmission rates, and higher costs compared to anterior fusion, but was associated with a lower rate of reoperation.
GLOBAL SPINE JOURNAL
(2021)