Integrating GWAS and Transcriptomics to Identify the Molecular Underpinnings of Thermal Stress Responses in Drosophila melanogaster

Insect responses to heat: physiological mechanisms, evolution and ecological implications in a warming world

(2020) Daniel González‐Tokman et al.   BIOLOGICAL REVIEWS

High-Throughput Assays of Critical Thermal Limits in Insects

(2020) David N. Awde et al.   Jove-Journal of Visualized Experiments

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

(2019) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

The central nervous system and muscular system play different roles for chill coma onset and recovery in insects

(2019) Mads Kuhlmann Andersen et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Stage-specific genotype-by-environment interactions for cold and heat hardiness in Drosophila melanogaster

(2019) Philip J. Freda et al.   HEREDITY

Thermal tolerance patterns across latitude and elevation

(2019) Jennifer Sunday et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The mode of action of Fruitless: Is it an easy matter to switch the sex?

(2019) Kosei Sato et al.   GENES BRAIN AND BEHAVIOR

Insights into the Functions of LncRNAs in Drosophila

(2019) Keqin Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial dysfunction and infection generate immunity-fecundity tradeoffs in Drosophila

(2018) Justin L Buchanan et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Genetic variation in the shape of cold-survival curves in a single fly population suggests potential for selection from climate variability

(2018) N. M. Teets et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Central nervous system shutdown underlies acute cold tolerance in tropical and temperateDrosophilaspecies

(2018) Mads Kuhlmann Andersen et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Nitric Oxide Controls Constitutive Freezing Tolerance in Arabidopsis by Attenuating the Levels of Osmoprotectants, Stress-Related Hormones and Anthocyanins

(2018) Álvaro Costa-Broseta et al.   Scientific Reports

Alterations of GABAergic Neuron-Associated Extracellular Matrix and Synaptic Responses in Gad1-Heterozygous Mice Subjected to Prenatal Stress

(2018) Tianying Wang et al.   Frontiers in Cellular Neuroscience

FlyBase 2.0: the next generation

(2018) Jim Thurmond et al.   NUCLEIC ACIDS RESEARCH

Genetic variation for tolerance to high temperatures in a population of Drosophila melanogaster

(2018) Carmen Rolandi et al.   Ecology and Evolution

Transcriptome Analysis Reveals Candidate Genes for Cold Tolerance in Drosophila ananassae

(2018) Annabella Königer et al.   Genes

Environmental variation partitioned into separate heritable components

(2017) Michael Ørsted et al.   EVOLUTION

Variation in Position Effect Variegation Within a Natural Population

(2017) Keegan J. P. Kelsey et al.   GENETICS

Genetic Decoupling of Thermal Hardiness across Metamorphosis in Drosophila melanogaster

(2017) Philip J Freda et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Proteome stability, heat hardening and heat-shock protein expression profiles inCataglyphisdesert ants

(2017) Quentin Willot et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Survival and gene expression under different temperature and humidity regimes in ants

(2017) Dimitri Stucki et al.   PLoS One

Nitric Oxide (NO) in Plant Heat Stress Tolerance: Current Knowledge and Perspectives

(2017) Santisree Parankusam et al.   Frontiers in Plant Science

Variation in Position Effect Variegation Within a Natural Population

(2017) Keegan J. P. Kelsey et al.   GENETICS

Charting the genotype-phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel

(2017) Trudy F.C. Mackay et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Insect cold hardiness: metabolic, gene, and protein adaptation1This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

(2017) Kenneth B. Storey et al.   CANADIAN JOURNAL OF ZOOLOGY

Effects of short-term heat shock and physiological responses to heat stress in two Bradysia adults, Bradysia odoriphaga and Bradysia difformis

(2017) Guodong Zhu et al.   Scientific Reports

Canalization of gene expression is a major signature of regulatory cold adaptation in temperate Drosophila melanogaster

(2016) Korbinian von Heckel et al.   BMC GENOMICS

Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation

(2016) Arnaldo Carreira-Rosario et al.   DEVELOPMENTAL CELL

Linear reaction norms of thermal limits in Drosophila : predictable plasticity in cold but not in heat tolerance

(2016) Mads Fristrup Schou et al.   FUNCTIONAL ECOLOGY

Gene expression under thermal stress varies across a geographical range expansion front

(2016) Lesley T. Lancaster et al.   MOLECULAR ECOLOGY

Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation inDrosophila melanogaster

(2016) Alan O. Bergland et al.   MOLECULAR ECOLOGY

Thermal fluctuations affect the transcriptome through mechanisms independent of average temperature

(2016) Jesper Givskov Sørensen et al.   Scientific Reports

A Quantitative Genomic Approach for Analysis of Fitness and Stress Related Traits in aDrosophila melanogasterModel Population

(2016) Palle Duun Rohde et al.   International Journal of Genomics

Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome

(2016) Heath A. MacMillan et al.   Scientific Reports

Sodium distribution predicts the chill tolerance of Drosophila melanogaster raised in different thermal conditions

(2015) Heath A. MacMillan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Heat tolerance inDrosophila subobscuraalong a latitudinal gradient: Contrasting patterns between plastic and genetic responses

(2015) Luis E. Castañeda et al.   EVOLUTION

Thermal variation, thermal extremes and the physiological performance of individuals

(2015) W. W. Dowd et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'

(2015) P. A. Fields et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

An invitation to measure insect cold tolerance: Methods, approaches, and workflow

(2015) Brent J. Sinclair et al.   JOURNAL OF THERMAL BIOLOGY

Longevity GWAS Using theDrosophilaGenetic Reference Panel

(2015) Dobril K. Ivanov et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Constraints, independence, and evolution of thermal plasticity: Probing genetic architecture of long- and short-term thermal acclimation

(2015) Alison R. Gerken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concurrent effects of cold and hyperkalaemia cause insect chilling injury

(2015) Heath A. MacMillan et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Temperature-Stress Resistance and Tolerance along a Latitudinal Cline in North American Arabidopsis lyrata

(2015) Guillaume Wos et al.   PLoS One

Cold truths: how winter drives responses of terrestrial organisms to climate change

(2014) Caroline M. Williams et al.   BIOLOGICAL REVIEWS

Developmental thermal plasticity amongDrosophila melanogasterpopulations

(2014) L. C. Fallis et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Cold-induced depolarization of insect muscle: differing roles of extracellular K+ during acute and chronic chilling

(2014) H. A. MacMillan et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Diversity and dynamics of the Drosophila transcriptome

(2014) James B. Brown et al.   NATURE

Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits

(2014) Mary F. Durham et al.   Nature Communications

Genomic Evidence of Rapid and Stable Adaptive Oscillations over Seasonal Time Scales in Drosophila

(2014) Alan O. Bergland et al.   PLoS Genetics

Serum Response Factor-Mediated Gene Regulation in a Drosophila Visual Working Memory

(2013) Julia Thran et al.   CURRENT BIOLOGY

New Levels of Transcriptome Complexity at Upper Thermal Limits in Wild Drosophila Revealed by Exon Expression Analysis

(2013) Marina Telonis-Scott et al.   GENETICS

Proteomic profiling of thermal acclimation in Drosophila melanogaster

(2013) Hervé Colinet et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Introns in UTRs: Why we should stop ignoring them

(2012) Alicia A. Bicknell et al.   BIOESSAYS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Temperature and neuronal circuit function: compensation, tuning and tolerance

(2012) R Meldrum Robertson et al.   CURRENT OPINION IN NEUROBIOLOGY

PHYLOGENETIC CONSTRAINTS IN KEY FUNCTIONAL TRAITS BEHIND SPECIES’ CLIMATE NICHES: PATTERNS OF DESICCATION AND COLD RESISTANCE ACROSS 95DROSOPHILASPECIES

(2012) Vanessa Kellermann et al.   EVOLUTION

IN A VARIABLE THERMAL ENVIRONMENT SELECTION FAVORS GREATER PLASTICITY OF CELL MEMBRANES IN DROSOPHILA MELANOGASTER

(2012) Brandon S. Cooper et al.   EVOLUTION

Genome-wide patterns of latitudinal differentiation among populations ofDrosophila melanogasterfrom North America

(2012) Daniel K. Fabian et al.   MOLECULAR ECOLOGY

The Drosophila melanogaster Genetic Reference Panel

(2012) Trudy F. C. Mackay et al.   NATURE

Combined transcriptomic and metabolomic approach uncovers molecular mechanisms of cold tolerance in a temperate flesh fly

(2012) Nicholas M. Teets et al.   PHYSIOLOGICAL GENOMICS

Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster

(2012) Allison L. Weber et al.   PLoS One

Upper thermal limits of Drosophila are linked to species distributions and strongly constrained phylogenetically

(2012) V. Kellermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic Plasticity of the Drosophila Transcriptome

(2012) Shanshan Zhou et al.   PLoS Genetics

The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila

(2011) Subhash C. Lakhotia et al.   CHROMOSOMA

A comparison of Frost expression among species and life stages of Drosophila

(2011) X. Bing et al.   INSECT MOLECULAR BIOLOGY

Basal cold but not heat tolerance constrains plasticity among Drosophila species (Diptera: Drosophilidae)

(2011) C. NYAMUKONDIWA et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Silkworm Thermal Biology: A Review of Heat Shock Response, Heat Shock Proteins and Heat Acclimation in the Domesticated Silkworm,Bombyx mori

(2011) H. B. Manjunatha et al.   JOURNAL OF INSECT SCIENCE

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Contributions of astrocytes to synapse formation and maturation — Potential functions of the perisynaptic extracellular matrix

(2010) Andreas Faissner et al.   BRAIN RESEARCH REVIEWS

Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila

(2010) N. Usha et al.   DEVELOPMENTAL BIOLOGY

Gene and protein expression of Drosophila Starvin during cold stress and recovery from chill coma

(2010) Hervé Colinet et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

A comprehensive assessment of geographic variation in heat tolerance and hardening capacity in populations of Drosophila melanogaster from eastern Australia

(2010) C. M. SGRÒ et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Transcriptomic responses to heat stress in invasive and native blue mussels (genus Mytilus): molecular correlates of invasive success

(2010) B. L. Lockwood et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Identification of X-linked quantitative trait loci affecting cold tolerance in Drosophila melanogaster and fine mapping by selective sweep analysis

(2010) NICOLAS SVETEC et al.   MOLECULAR ECOLOGY

The dual role of the extracellular matrix in synaptic plasticity and homeostasis

(2010) Alexander Dityatev et al.   NATURE REVIEWS NEUROSCIENCE

Functional Characterization of the Frost Gene in Drosophila melanogaster: Importance for Recovery from Chill Coma

(2010) Hervé Colinet et al.   PLoS One

Global analysis of thermal tolerance and latitude in ectotherms

(2010) J. M. Sunday et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

What determines a species’ geographical range? Thermal biology and latitudinal range size relationships in European diving beetles (Coleoptera: Dytiscidae)

(2009) Piero Calosi et al.   JOURNAL OF ANIMAL ECOLOGY

Selection for cold resistance alters gene transcript levels in Drosophila melanogaster

(2009) M. Telonis-Scott et al.   JOURNAL OF INSECT PHYSIOLOGY

Sequence-Based Analysis of Protein Energy Landscapes Reveals Nonuniform Thermal Adaptation within the Proteome

(2009) J. Gu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Use-Dependent Plasticity in Clock Neurons Regulates Sleep Need in Drosophila

(2009) Jeffrey M. Donlea et al.   SCIENCE