A cell is more than the sum of its (dilute) parts: A brief history of quinary structure

Direct Evidence for Metabolon Formation and Substrate Channeling in Recombinant TCA Cycle Enzymes

(2016) Beyza Bulutoglu et al.   ACS Chemical Biology

Grasping the nature of the cell interior: fromPhysiological ChemistrytoChemical Biology

(2016) Ciara Kyne et al.   FEBS Journal

Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

(2016) John B. Jordan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure

(2016) Kang Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Electrostatic Contributions to Protein Quinary Structure

(2016) Rachel D. Cohen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Applications of 19F-NMR in Fragment-Based Drug Discovery

(2016) Raymond Norton et al.   MOLECULES

Disorder in the court

(2016) T. Reid Alderson et al.   NATURE

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

The architecture of respiratory supercomplexes

(2016) James A. Letts et al.   NATURE

The architecture of the mammalian respirasome

(2016) Jinke Gu et al.   NATURE

Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells

(2016) Letizia Barbieri et al.   Nature Protocols

Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment

(2016) Clifford T Gee et al.   Nature Protocols

In-cell thermodynamics and a new role for protein surfaces

(2016) Austin E. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial colocalization and functional link of purinosomes with mitochondria

(2016) J. B. French et al.   SCIENCE

Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

(2016) Tomas Laursen et al.   SCIENCE

Combined ligand-observe 19F and protein-observe 15N,1H-HSQC NMR suggests phenylalanine as the key Δ-somatostatin residue recognized by human protein disulfide isomerase

(2016) Kirsty L. Richards et al.   Scientific Reports

Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain through Protein-Observed19F NMR Spectroscopy

(2015) Clifford T. Gee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Architecture of the Purinosome Involved in Human De Novo Purine Biosynthesis

(2015) Minjoung Kyoung et al.   BIOCHEMISTRY

Probing Protein Quinary Interactions by In-Cell Nuclear Magnetic Resonance Spectroscopy

(2015) Subhabrata Majumder et al.   BIOCHEMISTRY

Respiratory supercomplexes plasticity and implications

(2015) Yidong Bai   Frontiers in Bioscience-Landmark

Thermodynamics of protein destabilization in live cells

(2015) Jens Danielsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinosome formation as a function of the cell cycle

(2015) Chung Yu Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinary structure modulates protein stability in cells

(2015) William B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular pH modulates quinary structure

(2015) Rachel D. Cohen et al.   PROTEIN SCIENCE

Protein interaction patterns in different cellular environments are revealed by in-cell NMR

(2015) Letizia Barbieri et al.   Scientific Reports

Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling Revealed by Cross-Linking and Mass Spectrometry

(2014) Fei Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Residue level quantification of protein stability in living cells

(2014) W. B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific ion effects on macromolecular interactions inEscherichia coliextracts

(2014) Ciara Kyne et al.   PROTEIN SCIENCE

The function of the respiratory supercomplexes: The plasticity model

(2013) Rebeca Acin-Perez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes

(2013) Eugenia Mileykovskaya et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Intracellular protein and nucleic acid measured in eight cell types using deep-ultraviolet mass mapping

(2013) Man C. Cheung et al.   CYTOMETRY PART A

The Extracellular Protein VlsE Is Destabilized Inside Cells

(2013) Irisbel Guzman et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

(2012) Andres Binolfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Simple and inexpensive incorporation of 19F-Tryptophan for protein NMR spectroscopy

(2012) Peter B. Crowley et al.   CHEMICAL COMMUNICATIONS

Mapping Protein-Protein Proximity in the Purinosome

(2012) Yijun Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temperature dependence of protein folding kinetics in living cells

(2012) M. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring Weak, Transient Protein–Protein Interactions in Crowded In Vivo Environments by In-Cell Nuclear Magnetic Resonance Spectroscopy

(2011) Qinghua Wang et al.   BIOCHEMISTRY

Protein Stability and Folding Kinetics in the Nucleus and Endoplasmic Reticulum of Eucaryotic Cells

(2011) A. Dhar et al.   BIOPHYSICAL JOURNAL

Protein Interactions in the Escherichia coli Cytosol: An Impediment to In-Cell NMR Spectroscopy

(2011) Peter B. Crowley et al.   CHEMBIOCHEM

Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1

(2011) Thorsten Althoff et al.   EMBO JOURNAL

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

(2011) Florence Verrier et al.   Nature Chemical Biology

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography

(2011) N. V. Dudkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Internal and Global Protein Motion Assessed with a Fusion Construct and In-Cell NMR Spectroscopy

(2010) Christopher O. Barnes et al.   CHEMBIOCHEM

Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2

(2010) Songon An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-assisted mechanism for functional metabolic macromolecular complex formation

(2010) S. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formulation and manufacturability of biologics

(2009) Steven J Shire   CURRENT OPINION IN BIOTECHNOLOGY

Protein19F NMR inEscherichia coli

(2009) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein structure determination in living cells by in-cell NMR spectroscopy

(2009) Daisuke Sakakibara et al.   NATURE

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

(2009) Kohsuke Inomata et al.   NATURE

Megacomplex organization of the oxidative phosphorylation system by structural analysis of respiratory supercomplexes from potato

(2008) Jelle B. Bultema et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Differential Dynamical Effects of Macromolecular Crowding on an Intrinsically Disordered Protein and a Globular Protein: Implications for In-Cell NMR Spectroscopy

(2008) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL

Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution

(2008) Bo Huang et al.   NATURE METHODS

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE

Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy

(2008) B. Huang et al.   SCIENCE