Article
Biochemistry & Molecular Biology
Yueyun Ding, Yinhui Hou, Zijing Ling, Qiong Chen, Tao Xu, Lifei Liu, Na Yu, Wenliang Ni, Xiaoling Ding, Xiaodong Zhang, Xianrui Zheng, Wenbin Bao, Zongjun Yin
Summary: This study assessed the whole transcriptome expression profiles of pigs' Longissimus dorsi muscle with high and low IMF content to identify genes involved in porcine IMF adipogenesis. The findings revealed the involvement of non-coding RNAs in fatty acid metabolic processes, lipid metabolism, and fat cell differentiation. The study also constructed competing endogenous RNAs (ceRNA) regulatory networks, highlighting the roles of lncRNAs, circRNAs, and miRNAs in IMF deposition. These findings provide potential regulators and molecular regulatory networks for future research on IMF traits in pigs, which can aid in improving pork quality through marker-assisted selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yanxia Chen, Dong Chen, Jing Wang, Yu Zhang, Ji Zhang, Bing Chen, Yaru Chen, Yi Zhang, Cailing Ma
Summary: Through RNA sequencing, this study identified dysregulated lncRNAs and mRNAs in cervical cancer tissues of Uyghur women in western China, revealing their involvement in viral carcinogenesis, cell cycle, and cytokine-cytokine receptor signaling. Specifically, two miRNA-host lncRNAs were found to be upregulated in cervical cancer samples but associated with prolonged survival time of patients. Additionally, a network of 545 lncRNAs potentially regulating miRNAs as ceRNAs in cervical cancer was identified.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Xiaonan Xu, Kaizhen Wang, Olga Vera, Akanksha Verma, Neel Jasani, Ilah Bok, Olivier Elemento, Dongliang Du, Xiaoqing Yu, Florian A. Karreth
Summary: The study reveals that ceRNAs play a crucial role in the oncogenic effects of somatic copy-number alterations (CNA), sequestering tumor suppressor microRNAs and promoting cancer progression and metastasis.
Article
Oncology
HengChen Liu, MingZhao Zhang, ManYu Shi, TingTing Zhang, ZeNan Zhang, QingBo Cui, ShuLong Yang, ZhaoZhu Li
Summary: In this study, multiple RNAs were evaluated in Wilms tumor samples to construct predictive survival models and a survival-related ceRNA network. The models showed good prognostic ability and were highly correlated with tumor stage and histological classification. These findings provide potential new biomarkers for improving the prognosis and treatment of Wilms tumor patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yu-Yuan Hu, Xin-Meng Cheng, Nan Wu, Yang Tao, Xue-Ning Wang
Summary: This article summarizes the roles of various non-coding RNAs in the pathogenesis of aortic dissection and discusses their potential as clinical biomarkers and therapeutic targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yuyao Ji, Tao Yan, Shijie Zhu, Runda Wu, Miao Zhu, Yangyang Zhang, Changfa Guo, Kang Yao
Summary: This study explored the ceRNA mechanism in coronary artery disease (CAD) using bioinformatics analysis and identified three crucial ceRNA regulatory networks that play key roles in the occurrence and development of CAD, providing novel insights into the ceRNA mechanism in CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Mathematical & Computational Biology
Jie Qiu, Maolin Sun, Chuanshan Zang, Liwei Jiang, Zuorong Qin, Yan Sun, Mingbo Liu, Wenwei Zhang
Summary: This study identified potential circRNAs, miRNAs, and mRNAs in papillary thyroid carcinoma through multiomics analysis, revealing their regulatory networks. Key genes were found to be associated with patient prognosis and clinical characteristics, with LPAR5 potentially affecting patient survival and other genes potentially correlated with PTC metastasis.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Simona Cataldi, Mariagiovanna Tramontano, Valerio Costa, Marianna Aprile, Alfredo Ciccodicola
Summary: The increasing prevalence of diabetes mellitus worldwide leads to a higher incidence of macro- and micro-vascular complications, including diabetic retinopathy (DR), which is the leading cause of blindness in older diabetic patients. Chronic hyperglycemia is the main factor causing damage to retinal cells. Oxidative stress, inflammatory factors, and vascular endothelial growth factor signaling have been identified as contributors to the onset and progression of DR. Emerging evidence also suggests the involvement of non-coding RNA, particularly long non-coding RNAs (lncRNAs), in DR pathogenesis.
Article
Genetics & Heredity
Yujuan Yang, Qi Sun, Jing Guo, Zhen Liu, Jianwei Wang, Yao Yao, Pengyi Yu, Jiayu Cao, Yu Zhang, Xicheng Song
Summary: LncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) networks are believed to regulate the development of various inflammatory diseases. In this study, a ceRNA network associated with allergic rhinitis (AR) was constructed using microarray analysis and bioinformatics methods. The network may provide potential biomarkers for the diagnosis and treatment of AR.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Quanah J. Hudson, Katharina Proestling, Alexandra Perricos, Lorenz Kuessel, Heinrich Husslein, Rene Wenzl, Iveta Yotova
Summary: Studies have shown that lncRNAs play an important role in the pathogenesis of endometriosis, with SNPs and genome-wide transcriptomic studies confirming this.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Giasemi C. Eptaminitaki, Nora Wolff, Dimitris Stellas, Konstantinos Sifakis, Stavroula Baritaki
Summary: Long non-coding RNAs (lncRNAs) play critical roles in cancer immunity, influencing tumorigenesis, malignant characteristics, and regulating cancer immune evasion and treatment response.
Review
Genetics & Heredity
Maedeh Bagheri Moghaddam, Majid Maleki, Maziar Oveisee, Mahrokh Bagheri Moghaddam, Maedeh Arabian, Mahshid Malakootian
Summary: Cardiomyopathies are a group of cardiac diseases that lead to heart failure and mortality. Circular RNAs, a novel type of noncoding RNAs with unique structure, have been found to play significant roles in cardiomyopathies and have potential clinical applications.
Review
Biochemistry & Molecular Biology
Edyta Koscianska, Emilia Kozlowska, Agnieszka Fiszer
Summary: The role of non-coding RNAs in neuromuscular diseases, particularly in myotonic dystrophy type 1 and 2, and the impact of expanded repeat-containing transcripts on miRNA-mediated RNA crosstalk, are highlighted in this review. Specifically, the potential for long repeat tracts in mutant transcripts to act as potent miRNA sponges affecting ceRNA crosstalk in these diseases is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jianguo Wu, Laura E. Nagy, Li Wang
Summary: Long non-coding RNAs (lncRNAs) are a diverse class of RNA molecules longer than 200 nucleotides, involved in gene regulation and associated with disease pathogenesis. The small heterodimer partner (SHP) is an orphan nuclear receptor playing a crucial role in various biological processes. Recent findings demonstrate the regulatory relationship between lncRNAs and SHP in liver disease.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Cell Biology
Aleksa Petkovic, Sanja Erceg, Jelena Munjas, Ana Ninic, Sandra Vladimirov, Aleksandar Davidovic, Luka Vukmirovic, Marko Milanov, Dane Cvijanovic, Tijana Mitic, Miron Sopic
Summary: Despite efforts to develop new therapies, atherosclerotic cardiovascular diseases (ASCVD) remain a leading cause of death worldwide. However, current approaches to prognosis, diagnosis, and classification of acute coronary syndrome do not consider the diversity of plaque phenotypes.
Letter
Biochemistry & Molecular Biology
Feng Liu, Huiyang Yu, Yingtian Deng, Jingyuan Zheng, Minglei Liu, Lijun Ou, Bozhi Yang, Xiongze Dai, Yanqing Ma, Shengyu Feng, Shuang He, Xuefeng Li, Zhuqing Zhang, Wenchao Chen, Shudong Zhou, Rong Chen, Minmin Liu, Sha Yang, Ruimin Wei, Huadong Li, Feng Li, Bo Ouyang, Xuexiao Zou
Article
Geriatrics & Gerontology
Ruichan Jiang, Jiaming Gao, Junyan Shen, Xiaoqi Zhu, Hao Wang, Shengyu Feng, Ce Huang, Haitao Shen, Hailiang Liu
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Shengyu Feng, Ce Huang, Liuling Guo, Hao Wang, Hailiang Liu
Summary: This study identified a 12-gene signature that can help predict the prognosis of lung adenocarcinoma (LUAD) patients. The signature showed better stability and accuracy in predicting overall survival compared to other published signatures. Functional analysis revealed that these genes are related to immunity and are significantly negatively correlated with risk score.
Article
Microbiology
Ce Huang, Shengyu Feng, Fengjiao Huo, Hailiang Liu
Summary: Oral antibiotics have long-term negative effects on the intestinal microbiota, causing an imbalance in bacterial populations and increasing the risk of host disease.
MICROBIOLOGY SPECTRUM
(2022)
Article
Geriatrics & Gerontology
Xue Gong, Haitao Shen, Liuling Guo, Ce Huang, Tingting Su, Hao Wang, Shengyu Feng, Shanshan Yang, Fenjiao Huo, Haifeng Liu, Jianbo Zhu, Jian-Kang Zhu, Hongbin Li, Hailiang Liu
Summary: Glycyrrhizic acid (GA) exerts anti-aging effects by binding to S100A8 to remodel the immune system of aged mice.
Article
Microbiology
Xiaoqi Zhu, Junyan Shen, Shengyu Feng, Ce Huang, Hao Wang, Fengjiao Huo, Hailiang Liu
Summary: This study finds that metformin alters the composition of the gut microbiota and improves cognitive function in aged mice by reducing the levels of the pro-inflammatory cytokine IL-6. By increasing the abundance of Akkermansia muciniphila, metformin mediates changes in the gut microbiota, resulting in cognitive improvement.
Article
Biology
Shengyu Feng, Liuling Guo, Hao Wang, Shanshan Yang, Hailiang Liu
Summary: The PncA gene in microbiota plays an important role in regulating NAD(+) synthesis in the host, thereby providing a potential target for modulating host NAD(+) levels.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Xiaoqi Zhu, Junyan Shen, Shengyu Feng, Ce Huang, Zhongmin Liu, Yi Eve Sun, Hailiang Liu