Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6

Impaired vascular function with age and RhoGTPase

(2020) Edward Dempsey et al.   Aging-US

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments

(2020) Julia Matthias et al.   JOURNAL OF CLINICAL INVESTIGATION

Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease

(2020) Hiroshi Nishiwaki et al.   MOVEMENT DISORDERS

Microbiota modulate sympathetic neurons via a gut–brain circuit

(2020) Paul A. Muller et al.   NATURE

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation

(2020) Dehui Chang et al.   IMMUNITY

Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance

(2020) Juneyoung Lee et al.   Gut Microbes

High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats

(2019) Min Yu et al.   BRAIN BEHAVIOR AND IMMUNITY

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

(2019) Rosina Pryor et al.   CELL

Regulation of inflammation as an anti‐aging intervention

(2019) Joana Neves et al.   FEBS Journal

Microglia and the Aging Brain: Are Senescent Microglia the Key to Neurodegeneration?

(2019) Dafina M. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

(2019) María Fernanda Zurita et al.   Gut Microbes

The multiple sclerosis gut microbiota: A systematic review

(2019) Ali Mirza et al.   Multiple Sclerosis and Related Disorders

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions

(2018) Sophie Miquel et al.   AGEING RESEARCH REVIEWS

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

(2018) Benthe van der Lugt et al.   Aging-US

Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway

(2018) Paige V. Bauer et al.   Cell Metabolism

Aging, inflammation and the environment

(2018) Arsun Bektas et al.   EXPERIMENTAL GERONTOLOGY

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Trim33 mediates the proinflammatory function of Th17 cells

(2018) Shinya Tanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of Peripheral Interleukin-6 with Global Cognitive Decline in Non-demented Adults: A Meta-Analysis of Prospective Studies

(2018) Steven Bradburn et al.   Frontiers in Aging Neuroscience

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

(2018) Kyria M. Webster et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

(2018) Hemraj B. Dodiya et al.   NEUROBIOLOGY OF DISEASE

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

(2018) Monica Bodogai et al.   Science Translational Medicine

Akkermansia muciniphila and its role in regulating host functions

(2017) Muriel Derrien et al.   MICROBIAL PATHOGENESIS

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

(2017) Ilse Gantois et al.   NATURE MEDICINE

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

(2017) Svetlana Di Benedetto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Metformin Is Associated With Higher Relative Abundance of Mucin-DegradingAkkermansia muciniphilaand Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

(2016) Jacobo de la Cuesta-Zuluaga et al.   DIABETES CARE

Persistent microbiome alterations modulate the rate of post-dieting weight regain

(2016) Christoph A. Thaiss et al.   NATURE

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding the Role of T Cells in CNS Homeostasis

(2016) Erik Ellwardt et al.   TRENDS IN IMMUNOLOGY

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Aguamiel concentrate from Agave salmiana and its extracted saponins attenuated obesity and hepatic steatosis and increased Akkermansia muciniphila in C57BL6 mice

(2016) Ana María Leal-Díaz et al.   Scientific Reports

Diet Dominates Host Genotype in Shaping the Murine Gut Microbiota

(2015) Rachel N. Carmody et al.   Cell Host & Microbe

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Gut microbiota and aging

(2015) P. W. OToole et al.   SCIENCE

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

(2014) Linlin Guo et al.   CELL

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice

(2014) Fernando F Anhê et al.   GUT

Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity

(2014) Amandine Everard et al.   ISME Journal

Interleukin 6 and cognitive dysfunction

(2014) Isabel Trapero et al.   METABOLIC BRAIN DISEASE

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Novel Gut-Based Pharmacology of Metformin in Patients with Type 2 Diabetes Mellitus

(2014) Antonella Napolitano et al.   PLoS One

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

TAM Receptors Affect Adult Brain Neurogenesis by Negative Regulation of Microglial Cell Activation

(2013) R. Ji et al.   JOURNAL OF IMMUNOLOGY

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

(2013) Nicolas Buchon et al.   NATURE REVIEWS MICROBIOLOGY

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster

(2013) Arshad Ayyaz et al.   Frontiers in Cellular and Infection Microbiology

Microbes inside—from diversity to function: the case of Akkermansia

(2012) Clara Belzer et al.   ISME Journal

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SMAD2 Is Essential for TGFβ-mediated Th17 Cell Generation

(2010) Nidhi Malhotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Supplementation and Life Span in Fischer-344 Rats

(2010) D. L. Smith et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults

(2008) Anna L. Marsland et al.   BIOLOGICAL PSYCHIATRY

Inflammaging as a prodrome to Alzheimer's disease

(2008) Brian Giunta et al.   Journal of Neuroinflammation