Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

(2018) John D. Belcher et al.   PLoS One

Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135in Transfer of Lipopolysaccharide from CD14 to MD-2

(2016) Jožica Vašl et al.   JOURNAL OF IMMUNOLOGY

Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

(2016) Gregory M Vercellotti et al.   MOLECULAR MEDICINE

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Modulation of Toll-Like Receptor 4. Insights from X-Ray Crystallography and Molecular Modeling

(2015) Javier Klett et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma–hemorrhage

(2015) Ryan Stapley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme as a danger molecule in pathogen recognition

(2015) Barbara Wegiel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammasome-Induced IL-1  Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases

(2015) S. M. Burm et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HemeBIND: a novel method for heme binding residue prediction by combining structural and sequence information

(2011) Rong Liu et al.   BMC BIOINFORMATICS

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll‐Like Receptor Agonists and Is Blocked by Hemopexin

(2010) Tian Lin et al.   JOURNAL OF INFECTIOUS DISEASES

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE