18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice

Apoptotic or Antiproliferative Activity of Natural Products against Keratinocytes for the Treatment of Psoriasis

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The increase of mTOR expression is consistent with FoxO1 decrease at gene level in acne but not in psoriasis

(2019) Serena Lembo et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injury in mice

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A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway

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The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis

(2018) Cristina Albanesi et al.   Frontiers in Immunology

The role of PI3K/AKT/FOXO signaling in psoriasis

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Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway

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Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway

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Mechanistic target of rapamycin complex 1 is involved in psoriasis and regulated by anti-TNF-α treatment

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18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration

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Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models

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Anti-Psoriasis Agents from Natural Plant Sources

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Rhodomyrtone as a potential anti-proliferative and apoptosis inducing agent in HaCaT keratinocyte cells

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Zanthoxylum bungeanum essential oil induces apoptosis of HaCaT human keratinocytes

(2016) Keyou Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Amentoflavone protects against psoriasis-like skin lesion through suppression of NF-κB-mediated inflammation and keratinocyte proliferation

(2016) Jingang An et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2

(2016) Taotao Ma et al.   Scientific Reports

Glycyrrhizin Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice and Inhibits TNF-a-Induced ICAM-1 Expression via NF-κB/MAPK in HaCaT Cells

(2015) Hui Xiong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid

(2015) Xinchi Feng et al.   DRUG METABOLISM REVIEWS

Modelling epidermis homoeostasis and psoriasis pathogenesis

(2015) H. Zhang et al.   Journal of the Royal Society Interface

Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin

(2015) Tianhui Niu et al.   PLoS One

Phosphoinositide-3 Kinase/Protein Kinase-B/Mammalian Target of Rapamycin Pathway in Psoriasis Pathogenesis. A Potential Therapeutic Target?

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Oxidative Stress and Antioxidants in Disease and Cancer: A Review

(2014) Rakesh Kumar Gupta et al.   Asian Pacific Journal of Cancer Prevention

Erythrodermic psoriasis with bullous pemphigoid: combination treatment with methotrexate and compound glycyrrhizin

(2014) Xiaoqing Si et al.   Diagnostic Pathology

Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3

(2014) Zhouwei Wu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis

(2014) SI QIN et al.   Molecular Medicine Reports

Reactive Oxygen Species Prevent Imiquimod-Induced Psoriatic Dermatitis through Enhancing Regulatory T Cell Function

(2014) Hyung-Ran Kim et al.   PLoS One

18β-Glycyrrhetinic Acid Suppresses Cell Proliferation through Inhibiting Thromboxane Synthase in Non-Small Cell Lung Cancer

(2014) Run-Yue Huang et al.   PLoS One

Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice

(2014) I. Khmaladze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chicoric Acid Induces Apoptosis in 3T3-L1 Preadipocytes through ROS-Mediated PI3K/Akt and MAPK Signaling Pathways

(2013) Haifang Xiao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice

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18β-Glycyrrhetinic Acid Inhibits Methicillin-Resistant Staphylococcus aureus Survival and Attenuates Virulence Gene Expression

(2012) Danyelle R. Long et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade

(2012) Anupam Mitra et al.   CYTOKINE

Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through the caspase- and mitochondria-dependent pathways

(2012) FU-SHIN CHUEH et al.   ONCOLOGY REPORTS

Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis

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Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity

(2011) Lin-Li Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Excretion profile of glycyrrhizin metabolite in human urine

(2011) Nina Kočevar Glavač et al.   FOOD CHEMISTRY

18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells

(2011) Gunjan Sharma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glutathione Peroxidase 1 Deficiency Attenuates Allergen-Induced Airway Inflammation by Suppressing Th2 and Th17 Cell Development

(2010) Hee Yeon Won et al.   ANTIOXIDANTS & REDOX SIGNALING

Pathobiology of Chronic Inflammatory Skin Diseases: Interplay Between Keratinocytes and Immune Cells as a Target for Anti-Inflammatory Drugs

(2010) C. Albanesi et al.   CURRENT DRUG METABOLISM

Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid Inhibit Inflammation via PI3K/Akt/GSK3β Signaling and Glucocorticoid Receptor Activation

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Hypolipidemic activity of 18β-glycyrrhetinic acid on streptozotocin-induced diabetic rats

(2009) Panneerselvam Kalaiarasi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress in the pathogenesis of psoriasis

(2009) Qiang Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

(2009) Antonella Di Cesare et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

The protective role of ROS in autoimmune disease

(2009) Malin Hultqvist et al.   TRENDS IN IMMUNOLOGY

Effects of isocamptothecin, a novel camptothecin analogue, on proliferation, apoptosis and telomerase activity in HaCaT cells

(2008) Jingrong Lin et al.   EXPERIMENTAL DERMATOLOGY

Interplay between keratinocytes and immune cells—Recent insights into psoriasis pathogenesis

(2008) Giulia Tonel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neuroprotective Effects of Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid in PC12 Cells via Modulation of the PI3K/Akt Pathway

(2008) Tzu-Chien Kao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

18β-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity

(2008) Chung Soo Lee et al.   LIFE SCIENCES

Review of Pharmacological Effects ofGlycyrrhiza sp. and its Bioactive Compounds

(2008) Marjan Nassiri Asl et al.   PHYTOTHERAPY RESEARCH