Article
Immunology
Ling Yan, Min-Qing Gu, Zhi-You Yang, Juan Xia, Peng Li, Eero Vasar, Li Tian, Cai Song
Summary: The study reveals that depression is associated with abnormal lipid metabolism, and treatment with Ω-3 PUFAs can effectively alleviate depression by restoring lipid metabolism and suppressing inflammatory response.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Qingyao Yu, Tiantian Wang, Feng Wang, Yong Yang, Canxia He, Wenge Yang, JinJie Zhang, Zuquan Zou
Summary: The study showed that n-3 PUFAs can increase insulin sensitivity and improve glucose tolerance by inhibiting inflammasome activity in pre-adipocytes.
Article
Biochemistry & Molecular Biology
Lei Hao, Yong-Hui Nie, Chih-Yu Chen, Xiang-Yong Li, Kanakaraju Kaliannan, Jing X. Kang
Summary: This study utilized a transgenic fat-1 mouse model to investigate the regulation of brown adipose tissue (BAT) morphology and function by n-3 polyunsaturated fatty acids (n-3 PUFAs). The findings showed that elevated tissue levels of n-3 PUFAs can alleviate high-fat diet-induced obesity by enhancing thermogenesis and reducing inflammation in BAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Nikolina Kolobaric, Ines Drenjancevic, Anita Matic, Petar Susnjara, Zrinka Mihaljevic, Martina Mihalj
Summary: This study demonstrated that supplementation of hen eggs with n-3 polyunsaturated fatty acids can alter lipid mediator levels, affect cytokine secretion by T lymphocytes, and shift immune responses towards resolving inflammation conditions in healthy individuals. Both diets significantly changed systemic levels of lipid mediators, but only the n-3 PUFAs group showed a shift towards anti-inflammatory prostanoids and increased levels of pro-resolving oxylipins. Additionally, functional capacity for cytokine secretion was significantly altered only in the n-3 PUFAs group with increased TGF-β1 and reduced IL-6 secretion.
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ornella Selmin, Andreas J. Papoutsis, Sabine Hazan, Christopher Smith, Nick Greenfield, Micah G. Donovan, Spencer N. Wren, Thomas C. Doetschman, Justin M. Snider, Ashley J. Snider, Sherry H-H Chow, Donato F. Romagnolo
Summary: This study compared the effects of a typical Western diet and a soybean oil-rich n-6HFD on gut inflammation and microbiome using a mouse model. The results showed that n-6HFD induced colonic inflammation and altered gut bacterial composition, promoting the growth of proinflammatory bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Josiah E. Hardesty, Jeffrey B. Warner, Ying L. Song, Eric C. Rouchka, Craig J. McClain, Dennis R. Warner, Irina A. Kirpich
Summary: The study reveals that n-3 polyunsaturated fatty acids can reduce alcohol-induced intestinal inflammation, enhance antibacterial capacity, and promote intestinal repair. This may be beneficial for intestinal damage caused by excessive alcohol consumption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Arzu Ulu, Jalene V. Velazquez, Abigail Burr, Stefanie N. Sveiven, Jun Yang, Carissa Bravo, Bruce D. Hammock, Tara M. Nordgren
Summary: Workers in agriculture industries are at a higher risk of developing pulmonary diseases due to inhalation of agricultural dust. Previous research has shown that the omega-3 polyunsaturated fatty acid (omega-3 PUFA) DHA has protective effects against the negative inflammatory effects of repetitive dust exposure in the lung. By manipulating the dietary intake of omega-3 PUFA and using transgenic mouse models, it is possible to attenuate agricultural dust-induced lung inflammation and improve resilience to its effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Rachel E. Walker, Valentina Parkhomenko, Yun Ying, Natalie Urrutia, Kevin J. Harvatine
Summary: This study compared the effects of saturated fatty acids (SFA) and n-6 polyunsaturated fatty acids (PUFA) on the incorporation of n-3 PUFA in milk and tissues of lactating mice and their offspring. The findings suggest that high dietary n-6 PUFA may suppress n-3 PUFA incorporation in neonates.
JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Viswanathan Saraswathi, Narendra Kumar, Weilun Ai, Thiyagarajan Gopal, Saumya Bhatt, Edward N. Harris, Geoffrey A. Talmon, Cyrus Desouza
Summary: The intake of myristic acid (MA) exacerbates obesity-associated insulin resistance, partially mediated by increased adipose tissue inflammation and secretion of resistin.
Article
Biochemistry & Molecular Biology
Seohyun Park, Jae-Joon Lee, Jisu Lee, Jennifer K. Lee, Jaemin Byun, Inyong Kim, Jung-Heun Ha
Summary: Obesity is closely associated with chronic inflammation and dyslipidemia, and the consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) may regulate obesity-related disorders. This study aimed to investigate the importance of n-3 PUFA consumption, including the ratio of n-6/n-3 PUFAs and the amount of n-3 PUFAs. The results suggest that a dietary intervention with a lower n-6/n-3 PUFA ratio can significantly alleviate metabolic dysfunction in LPS-induced ob/ob mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jiaomei Li, Yi Wan, Zhaohong Zheng, Huaqi Zhang, Yang Li, Xiaofei Guo, Kelei Li, Duo Li
Summary: Our study found that a maternal diet rich in n-3 PUFAs significantly reduces the risk of offspring developing mammary cancer, and supplementation of maternal n-3 PUFAs can also alter the composition of offspring's gut microbiota and decrease the levels of inflammatory factors.
Article
Biochemistry & Molecular Biology
Alexander V. Sorokin, Hildur Arnardottir, Maryia Svirydava, Qimin Ng, Yvonne Baumer, Alexander Berg, Carla J. Pantoja, Elizabeth M. Florida, Heather L. Teague, Zhi-Hong Yang, Pradeep K. Dagur, Tiffany M. Powell-Wiley, Zu-Xi Yu, Martin P. Playford, Alan T. Remaley, Nehal N. Mehta
Summary: Persistent skin inflammation and impaired resolution are key factors in psoriasis and associated complications. Omega-3 polyunsaturated fatty acids (PUFAs) have proven to be beneficial for inflammation and lipid function. However, the specific role of omega-3 PUFAs in psoriasis is still debated. In this study, EPA and DHA were compared in their treatment of psoriasis-like skin inflammation. The results suggest that modulating psoriasis with omega-3 PUFAs is clinically significant, with DHA showing potential superiority over EPA.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Shuai Mao, Huan Ma, Peipei Chen, Yubin Liang, Minzhou Zhang, Aleksander Hinek
Summary: The study showed that transgenic fat-1 mice with constantly elevated levels of endogenous omega-3 PUFA exhibited lower mortality and less cardiac dysfunction after LPS challenge, compared to wild type mice. The benefits included lower levels of pro-inflammatory markers and ROS, increased autophagic flux activities, and enhanced Sirt-1 and PPAR gamma signals.
Article
Gastroenterology & Hepatology
Di Zhang, Yu Zhang, Xiwu Zhang, Hongjun Zhai, Xiaoli Sun, Yiming Li
Summary: This study revealed that circ_0091579 promotes the progression of HCC by regulating the miR-1225-5p/PLCB1 axis, providing a novel molecular basis for HCC development.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Rheumatology
Haiyan Zhang, Yan Shao, Zihao Yao, Liangliang Liu, Hongbo Zhang, Jianbin Yin, Haoyu Xie, Kai Li, Pinglin Lai, Hua Zeng, Guozhi Xiao, Chun Zeng, Daozhang Cai, Xiaochun Bai
Summary: This study investigated the role of mechanical stress in cartilage ageing and osteoarthritis (OA) progression. It was found that mechanical overloading accelerated senescence in chondrocytes and articular cartilage. FBXW7 expression was downregulated in primary chondrocytes, mice cartilage, and cartilage of OA patients. FBXW7 deletion in chondrocytes induced chondrocyte senescence and accelerated cartilage catabolism, exacerbating OA. However, intra-articular injection of adenovirus expressing Fbxw7 alleviated OA in mice. Mechanistically, mechanical overloading decreased Fbxw7 mRNA transcription and FBXW7-mediated MKK7 degradation, stimulating JNK signalling. Inhibition of JNK activity improved chondrocyte senescence and cartilage degeneration.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Correction
Biochemistry & Molecular Biology
Junfeng Zhang, Hongwei Tian, Can Li, Lin Cheng, Shuang Zhang, Xiaomei Zhang, Ruibo Wang, Fen Xu, Lei Dai, Gang Shi, Xiaolei Chen, Yiming Li, Tao Du, Jie Deng, Yu Liu, Yang Yang, Yuquan Wei, Hongxin Deng
MOLECULAR IMMUNOLOGY
(2022)
Retraction
Oncology
Shuo Chen, Xi Chen, Wei Li, Tao Shan, Wan Run Lin, Jiancang Ma, Xijuan Cui, Wenbin Yang, Gang Cao, Yiming Li, Li Wang, Ya'an Kang
Letter
Rheumatology
Haiyan Zhang, Daozhang Cai, Xiaochun Bai
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yafei Zhang, Hongwei Lu, Hong Ji, Yiming Li
Summary: This study investigated the role of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and p53 in mucosal apoptosis in portal hypertensive gastropathy (PHG). The results showed that HIF-1 alpha and p53 were significantly upregulated in the gastric mucosa of PHG patients and animal models, and inhibition of these molecules could attenuate apoptosis. It was also found that HIF-1 alpha regulated the p53-induced mucosal epithelial apoptotic signaling pathway. Therefore, HIF-1 alpha and p53 may be potential therapeutic targets for PHG.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jun Yang, Wuju Zhang, Eryong Lai, Wen Liu, Pinglin Lai, Zhipeng Zou, Weidong Wang, Xiaochun Bai
Summary: Rheb1 plays an important role in bone metabolism, with Rheb1 KO mice showing impaired bone microarchitecture, inhibited bone formation, and increased bone resorption.
DNA AND CELL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jing-Jing He, Tian-Yuan Xiong, Yi-Jun Yao, Yong Peng, Jia-Fu Wei, Sen He, Yong Chen, Qiao Li, Zhen-Gang Zhao, Xin Wei, Wen-Xia Zhou, Yu-Jia Liang, Hong Tang, Guo Chen, Xuan Zhou, Ming-Xia Zheng, Wei Meng, Yan-Biao Liao, Yi-Jian Li, Yi-Ming Li, Fei Chen, Yuan-Weixiang Ou, Qi Liu, Xi Li, Xi Wang, Yi Zhang, Zhong-Kai Zhu, Hao-Ran Yang, Kai-Yu Jia, Mao Chen, Yuan Feng
Summary: This study investigated the impact of sex on outcomes following transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valves (BAVs). The results showed that women with BAVs had fewer comorbidities, while men had a higher proportion of type 1 BAV, more calcification, and larger aortic roots. Men had better in-hospital outcomes, except for the need for second valve implantation, but 1-year survival was comparable between sexes.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Yiming Li, Yan Lu, Xinmin Tan, Zilong Zhang, Feng Feng, Ruhong Li
Summary: This study investigated the effect of endotracheal tube (ETT) size on airway resistance (RAW) and dynamic lung compliance (COMPL) in patients undergoing laparoscopic colorectal surgery. The results showed that in the non-pneumoperitoneal state, a smaller ETT internal diameter resulted in higher RAW and lower COMPL. In the pneumoperitoneal state, the ETT size had no effect on COMPL, but the RAW was higher with an ID7.0 ETT compared to an ID8.0 ETT within a certain range.
Article
Chemistry, Multidisciplinary
Yu Wang, Qiong Xia, Xiao Hua, Yanyan Guo, Jing Shi, Yi-Ming Li
Summary: Activity-based ubiquitin probes (Ub-ABPs) are effective tools for studying the molecular mechanism and profiling of deubiquitinating enzymes (DUBs). However, the synthesis of commonly used biotin-bearing Ub-ABPs is technically challenging. In this study, a one-pot semi-synthetic strategy was developed to obtain Ub-ABPs carrying a biotin tag through enzymatic ligation, N-S acyl transfer, and aminolysis reaction without purification steps. These probes enable the capture of different DUBs families for enrichment and immunoblotting using the attached biotin tag.
CHINESE CHEMICAL LETTERS
(2023)
Review
Gastroenterology & Hepatology
Shu-Wu Zhao, Yi-Ming Li, Yi-Lin Li, Chen Su
Summary: The COVID-19 pandemic has been a global health threat for nearly 3 years and it often causes liver injury in addition to pulmonary complications. The incidence of liver injury is significantly increased in severe cases and understanding its causes is urgently needed. Clinical features of liver injury include abnormal liver function and imaging changes, which can be evaluated through tests and scans. Risk factors for liver injury in COVID-19 patients include male sex, preexisting liver disease, diabetes, obesity, and hypertension. The mechanism of liver injury caused by COVID-19 is not fully understood, but it is believed to be related to inflammatory response, hypoxic damage, ischemia-reperfusion injury, and drug side effects. This review summarizesthe existing literature on liver injury caused by COVID-19, including clinical features, underlying mechanisms, and potential risk factors. Clinical management and recommendations for patients with liver injury are also discussed.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pharmacology & Pharmacy
Guangzhi Liao, Xiangpeng Wang, Yiming Li, Xuefeng Chen, Ke Huang, Lin Bai, Yuyang Ye, Yong Peng
Summary: This study summarized the benefits and safety of antidyslipidemia pharmacotherapy in patients with chronic kidney disease. Statin-based therapies were found to significantly and safely reduce all-cause mortality and major composite cardiovascular events in non-dialysis CKD patients, especially in those with established coronary artery disease.
Article
Chemistry, Organic
Jia-Hui Tang, Ru-Jing Yuan, Jie Luo, Ning Wang, Jun Wang, Yi-Ming Li
Summary: We have developed a new strategy, called serine/threonine ligation (STL)-assisted diaminodiacid (DADA), for the flexible construction of disulfide surrogates. This strategy allows for the incorporation of more abundant -Aa-Ser/Thr-ligation sites, and has been successfully applied to synthesize intrachain and interchain disulfide surrogates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiming Li, Yu Wu, Jingjing He, Weili Jiang, Jianyong Wang, Yong Peng, Yuheng Jia, Tianyuan Xiong, Kaiyu Jia, Zhang Yi, Mao Chen
Summary: In this study, a deep learning algorithm was used to achieve rapid classification and diagnosis of coronary artery disease from CCTA images. The deep learning model can automatically segment the coronary artery quickly and accurately, delivering a diagnosis of >= 50% coronary artery stenosis. Artificial intelligence methods such as deep learning have the potential to significantly improve efficiency in CCTA image analysis.
EUROPEAN RADIOLOGY
(2022)
Article
Cell & Tissue Engineering
Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Mingjue Chen, Yuxiao Lai, Huiling Cao, Zengwu Shao, Guozhi Xiao
Summary: This study reveals that Kindlin-2 plays a critical role in inhibiting Nlrp3 inflammasome activation and maintaining the integrity of intervertebral disc homeostasis. Loss of Kindlin-2 leads to intervertebral disc degeneration, cell apoptosis, and extracellular matrix catabolism. Abnormal mechanical stress exacerbates the progression of intervertebral disc degeneration. Blocking Nlrp3 inflammasome activation and overexpression of Kindlin-2 can prevent and treat intervertebral disc degeneration.