BMP‐2 Signaling and Mechanotransduction Synergize to Drive Osteogenic Differentiation via YAP/TAZ

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells

(2020) Yong Hou et al.   Small

Volume Adaptation Controls Stem Cell Mechanotransduction

(2019) Luke G. Major et al.   ACS Applied Materials & Interfaces

Surface Roughness and Substrate Stiffness Synergize To Drive Cellular Mechanoresponse

(2019) Yong Hou et al.   NANO LETTERS

Receptor control in mesenchymal stem cell engineering

(2018) Matthew J. Dalby et al.   Nature Reviews Materials

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

(2018) Giovanna Brusatin et al.   NATURE MATERIALS

Cell–Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research

(2017) Andrew W. Holle et al.   NANO LETTERS

Force loading explains spatial sensing of ligands by cells

(2017) Roger Oria et al.   NATURE

Designer biomaterials for mechanobiology

(2017) Linqing Li et al.   NATURE MATERIALS

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

Dimensionality and spreading influence MSC YAP/TAZ signaling in hydrogel environments

(2016) Steven R. Caliari et al.   BIOMATERIALS

β3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner

(2016) Laure Fourel et al.   JOURNAL OF CELL BIOLOGY

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

(2015) Qiang Wei et al.   Beilstein Journal of Organic Chemistry

TAZ Protein Accumulation Is Negatively Regulated by YAP Abundance in Mammalian Cells

(2015) Megan L. Finch-Edmondson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanoscale Control of Surface Immobilized BMP-2: Toward a Quantitative Assessment of BMP-Mediated Signaling Events

(2015) Elisabeth H. Schwab et al.   NANO LETTERS

Stem cell mechanobiology: diverse lessons from bone marrow

(2015) Irena L. Ivanovska et al.   TRENDS IN CELL BIOLOGY

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Universal polymer coatings and their representative biomedical applications

(2015) Qiang Wei et al.   Materials Horizons

Protein Interactions with Polymer Coatings and Biomaterials

(2014) Qiang Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle

(2014) Asha Shekaran et al.   BIOMATERIALS

The synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiation

(2014) ShihJye Tan et al.   BIOMATERIALS

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

BMP growth factor signaling in a biomechanical context

(2013) Jessica Kopf et al.   BIOFACTORS

Effect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fate

(2013) Omar F. Zouani et al.   BIOMATERIALS

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

WWTR1 promotes cell proliferation and inhibits apoptosis through cyclin A and CTGF regulation in non-small cell lung cancer

(2013) Li Wang et al.   TUMOR BIOLOGY

Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells

(2013) Tobias A. Beyer et al.   Cell Reports

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation

(2011) Theresa L.M. Pohl et al.   Acta Biomaterialia

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2

(2011) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension

(2011) Yang-Kao Wang et al.   STEM CELLS AND DEVELOPMENT

Manipulation of the adhesive behaviour of skeletal muscle cells on soft and stiff polyelectrolyte multilayers

(2010) Kefeng Ren et al.   Acta Biomaterialia

Neogenin, a Receptor for Bone Morphogenetic Proteins

(2010) Meiko Hagihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlled Growth Factor Delivery for Tissue Engineering

(2009) Prakriti Tayalia et al.   ADVANCED MATERIALS

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum

(2009) Blanca Herrera et al.   BMC CELL BIOLOGY

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination

(2009) T. Fei et al.   GENOME RESEARCH

Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement

(2009) C. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers

(2008) Liudmila L. Kodach et al.   GASTROENTEROLOGY

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity

(2008) C. Gamell et al.   JOURNAL OF CELL SCIENCE