Uncovering the Mechanisms of Cryptotanshinone as a Therapeutic Agent Against Hepatocellular Carcinoma

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

(2019) Yubin Ji et al.   OncoTargets and Therapy

Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond

(2019) Masatoshi Kudo   WORLD JOURNAL OF GASTROENTEROLOGY

Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma

(2019) Shuo Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cryptotanshinone ameliorates renal ischaemia–reperfusion injury by inhibiting apoptosis and inflammatory response

(2019) Tao Bai et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Inhibition of murine hepatoma tumor growth by cryptotanshinone involves TLR7-dependent activation of macrophages and induction of adaptive antitumor immune defenses

(2019) Zhen Han et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

(2019) Ali S. Alzahrani   SEMINARS IN CANCER BIOLOGY

Locoregional treatments for hepatocellular carcinoma: Current evidence and future directions

(2019) Riccardo Inchingolo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Positron-emission tomography for hepatocellular carcinoma: Current status and future prospects

(2019) Ren-Cai Lu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway

(2019) Yang Zhou et al.   Frontiers in Neuroscience

Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations

(2019) Christina G. Towers et al.   JOURNAL OF CELL BIOLOGY

Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf-2 and NF-κB in Mice with Unilateral Ureteral Obstruction

(2018) Wei Wang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells

(2018) Julia Huei-Mei Chang et al.   ENVIRONMENTAL TOXICOLOGY

Cryptotanshinone inhibits cellular proliferation of human lung cancer cells through downregulation ofIGF-1R/PI3K/Akt signaling pathway

(2018) Jingtao Zhang et al.   ONCOLOGY REPORTS

Cryptotanshinone suppresses key onco-proliferative and drugresistant pathways of chronic myeloid leukemia by targeting STAT5 and STAT3 phosphorylation

(2018) Bowen Dong et al.   Science China-Life Sciences

Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells

(2018) Yufei Yang et al.   Cancer Medicine

Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1α nuclear translocation

(2018) Lin Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes

(2018) Hu‑Nan Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubChem 2019 update: improved access to chemical data

(2018) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

Cryptotanshinone inhibition of mammalian target of rapamycin pathway is dependent on oestrogen receptor alpha in breast cancer

(2017) Yanhong Pan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

(2017) Go J. Yoshida   Journal of Hematology & Oncology

Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity

(2017) Jiye Wang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database

(2017) Xia Wang et al.   NUCLEIC ACIDS RESEARCH

Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1-like Diabetic Rats

(2017) Shih-Hsiang Lo et al.   PHYTOTHERAPY RESEARCH

Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma

(2017) Zhiguo Chen et al.   Oncotarget

Autophagy protein LC3 regulates the fibrosis of hypertrophic scar by controlling Bcl-xL in dermal fibroblasts

(2017) Jihong Shi et al.   Oncotarget

Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells

(2016) Xiaoli Ran et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Eyes on systems pharmacology

(2016) Yu Chen et al.   PHARMACOLOGICAL RESEARCH

Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions

(2015) Avi Ashkenazi   JOURNAL OF CLINICAL INVESTIGATION

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents

(2013) Hui Sun et al.   Anti-Cancer Agents in Medicinal Chemistry

Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma

(2013) In-Ja Park et al.   APOPTOSIS

Systems pharmacology in drug discovery and therapeutic insight for herbal medicines

(2013) Chao Huang et al.   BRIEFINGS IN BIOINFORMATICS

Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway

(2013) Dong-Mei Zhang et al.   CARCINOGENESIS

STITCH 4: integration of protein–chemical interactions with user data

(2013) Michael Kuhn et al.   NUCLEIC ACIDS RESEARCH

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E

(2012) Yuqing Ge et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Liverome: a curated database of liver cancer-related gene signatures with self-contained context information

(2011) Langho Lee et al.   BMC GENOMICS

Targeting PI3K/mTOR Signaling in Cancer

(2011) B. M. Emerling et al.   CANCER RESEARCH

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PI3K/Akt/mTOR Pathway Inhibitors in Cancer: A Perspective on Clinical Progress

(2010) P. Wu et al.   CURRENT MEDICINAL CHEMISTRY

HIT: linking herbal active ingredients to targets

(2010) H. Ye et al.   NUCLEIC ACIDS RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro

(2009) Zhengrong Mei et al.   NEUROSCIENCE LETTERS

Cryptotanshinone, an Acetylcholinesterase Inhibitor fromSalvia miltiorrhiza, Ameliorates Scopolamine-Induced Amnesia in Morris Water Maze Task

(2009) Kelvin Wong et al.   PLANTA MEDICA