Article
Multidisciplinary Sciences
Dheeraj S. Roy, Ying Zhang, Tomomi Aida, Chenjie Shen, Keith M. Skaggs, Yuanyuan Hou, Morgan Fleishman, Olivia Mosto, Alyssa Weninger, Guoping Feng
Summary: A specific region of the anterior thalamic nuclei plays a key role in spatial working memory tasks in aged mice, and targeting this region may be more beneficial for cognitive functions with fewer unintended effects compared to direct manipulation of the prefrontal cortex. Activation of neurons or circuits in this region can improve working memory, while direct activation of prefrontal cortex neurons may lead to increased anxiety levels in aged mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Julian Macoveanu, Hanne Lie Kjaerstad, Maj Vinberg, Catherine Harmer, Patrick MacDonald Fisher, Gitte Moos Knudsen, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: The study found that patients with bipolar disorder exhibited hypo-activity in the dorsal prefrontal cortex (dPFC) and impaired cognitive function at diagnosis, while showing increased dPFC activity during the follow-up period. This increased activity may reflect a reduction in prefrontal cortex efficiency related to affective episodes, even though there was no deterioration in cognitive performance.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Nestor I. Martinez-Torres, Nallely Vazquez-Hernandez, Fabiola L. Martin-Amaya-Barajas, Mario Flores-Soto, Ignacio Gonzalez-Burgos
Summary: The study found that lesions induced by Ibotenic acid (IA) affect social behavior and working memory in rats, leading to decreased dendritic spine density and reduced protein content. Plastic changes in the proportion of dendritic spine types suggest the activation of compensatory processes in response to the adverse effects of the lesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Sihai Li, Christos Constantinidis, Xue-Lian Qi
Summary: The study investigated the roles of the dorsolateral prefrontal cortex and posterior parietal cortex in working memory, finding that neuronal activity can predict categorical judgments of information and deviations in firing rates reflect the contents of working memory.
Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Youngsun T. Cho, Flora Moujaes, Charles H. Schleifer, Martina Starc, Jie Lisa Ji, Nicole Santamauro, Brendan Adkinson, Antonija Kolobaric, Morgan Flynn, John H. Krystal, John D. Murray, Grega Repovs, Alan Anticevic
Summary: This study investigated how reward and loss impact spatial working memory precision and neural circuits in human subjects. The results showed that both reward and loss improved spatial working memory precision, with specific regions like precentral sulcus and intraparietal sulcus having increased BOLD signal related to better working memory precision. Conversely, areas straddling executive networks displayed decreased BOLD signal during incentivized working memory.
Review
Behavioral Sciences
Sihai Li, Matthew C. Rosen, Suha Chang, Samuel David, David J. Freedman
Summary: This article reviews the neural correlates and functional importance of working memory-related activity in higher-order cortical regions, particularly the prefrontal cortex. It also discusses emerging evidence of electrical stimulation as a potential therapy for ameliorating working memory deficits.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Craig W. Berridge, David M. Devilbiss, Andrea J. Martin, Robert C. Spencer, Rick L. Jenison
Summary: Goal-directed behavior relies on neuronal activity in the prefrontal cortex (PFC) and extended frontostriatal circuitry. Stress impairs frontostriatal-dependent cognition, but the underlying neural mechanisms are not well understood. This study investigated the effects of acute noise-stress on neural activity and connectivity within cognition-related frontostriatal circuitry in rats. The results showed that stress suppressed neuronal responses and disrupted neural coding and functional connectivity during a spatial working memory task, providing insights into the cognitive impairing effects of stress.
Article
Neurosciences
Megan Roussy, Benjamin Corrigan, Rogelio Luna, Roberto A. Gulli, Adam J. Sachs, Lena Palaniyappan, Julio C. Martinez-Trujilio
Summary: The study found that LPFC neurons maintain robust and distinct neural codes for mnemonic and perceptual visuospatial representations during naturalistic vision, with animals using different behavioral strategies for working memory and perception tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Sofia Faraza, Julia Waldenmaier, Martin Dyrba, Dominik Wolf, Florian U. Fischer, Kristel Knaepen, Bianca Kollmann, Oliver Tuescher, Harald Binder, Andreas Mierau, David Riedel, Andreas Fellgiebel, Stefan Teipel
Summary: The study found that high functional connectivity of the right DLPFC was significantly associated with training gains and improvement in visuospatial task performance, but the maintenance of cognitive gains was limited to the period directly after the training. Cognitive training can improve working memory function in older adults, but there are still limitations in terms of cognitive gains.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Qian Wang, Meng-wei Wang, Yan-yun Sun, Xiao-yan Hu, Pan-pan Geng, Hui Shu, Xiao-na Wang, Hao Wang, Jun-fang Zhang, Hong-qiang Cheng, Wei Wang, Xin-chun Jin
Summary: Increasing evidence suggests that chronic nicotine treatment can alleviate MK-801-induced schizophrenia-like symptoms and cognitive impairment in mice. This study found that nicotine treatment reversed the increased expression levels of PDZ and LIM domain 5 (Pdlim5) and prevented the decrease in CREB-regulated transcription coactivator 1 (CRTC1) in the prefrontal cortex (PFC), resulting in improved cognition in mice.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Behavioral Sciences
Wiktor Bilecki, Joachim Latusz, Kinga Gawlinska, Magdalena Chmelova, Marzena Mackowiak
Summary: The study showed that short-term adolescent social isolation did not significantly affect fear memory and anxiety in adult rats, but altered protein levels related to synapse maturation and energy transfer. Additionally, the impact of adolescent social isolation on normally developing brains was different than those with a history of MAM administration.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Xiaoyu Ma, Charles Zheng, Yenho Chen, Francisco Pereira, Zheng Li
Summary: The ability to perceive and locate spatial environments is crucial for animal survival. The medial prefrontal cortex (mPFC) has been implicated in spatially related behaviors, but its properties and how it is influenced by animal behavior are not well-defined. This study found that the population activity of mPFC neurons can predict animal locations, and this coding accuracy is higher in tasks involving working memory and reward-seeking.
Article
Geriatrics & Gerontology
Jian Wang, Wei Zhang, Ying Zhou, Jia Jia, Yuanfang Li, Kai Liu, Zheng Ye, Lirong Jin
Summary: This study investigates the relationship between longitudinal changes in prefrontal perfusion and mild cognitive impairment (MCI) in Parkinson's disease (PD) patients. The results suggest that reduced prefrontal cerebral blood flow (CBF) may impact cognitive functions, especially executive functions, at the early stages of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Coralie de Hemptinne, Witney Chen, Caroline A. Racine, Andreea L. Seritan, Andrew M. Miller, Maria S. Yaroshinsky, Sarah S. Wang, Roee Gilron, Simon Little, Ian Bledsoe, Marta San Luciano, Maya Katz, Edward F. Chang, Heather E. Dawes, Jill L. Ostrem, Philip A. Starr
Summary: The study found that beta spectral power in the prefrontal cortex of PD patients correlates with symptoms of depression and anxiety, providing a physiological basis for these non-motor features. This may be useful in the development of neurostimulation paradigms for anxiety and depression in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Aakash Bipin Gandhi, Eberechukwu Onukwugha, Husam Albarmawi, Abree Johnson, Daniela E. Myers, David Gray, Jose Alvir, Lauren Hynicka, Lisa M. Shulman
Summary: This study compared health care resource utilization between Medicare beneficiaries with and without Parkinson's disease over a 10-year period, finding that beneficiaries with PD had higher rates of inpatient admissions, emergency department visits, skilled nursing facility admissions, healthcare provider encounters, neurologist visits, rehabilitation service visits, and non-PD medication fills compared to those without PD. The results provide evidence for the allocation of healthcare resources for PD management.
Article
Psychiatry
Anissa Abi-Dargham, Jonathan A. Javitch, Mark Slifstein, Alan Anticevic, Monica E. Calkins, Youngsun T. Cho, Clara Fonteneau, Roberto Gil, Ragy Girgis, Raquel E. Gur, Ruben C. Gur, Jack Grinband, Joshua Kantrowitz, Christian Kohler, John Krystal, John Murray, Mohini Ranganathan, Nicole Santamauro, Jared Van Snellenberg, Zailyn Tamayo, Daniel Wolf, David Gray, Jeffrey Lieberman
Summary: Decades of research have shown the importance of optimal stimulation of cortical dopaminergic receptors, particularly the D1R receptor, for prefrontal-mediated cognition. Challenges in developing D1R targeting drugs include determining the optimal level of D1R stimulation and the unknown mechanism for stimulation, which could include partial or full agonism, biased agonism, or allosteric modulation. Previous drugs targeting D1R have faced issues like poor bioavailability and insufficient target engagement at tolerable doses, but newer drugs like CVL-562 offer potential solutions if carefully tested.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Geriatrics & Gerontology
Zackary A. Cope, Takeshi Murai, Stacey J. Sukoff Rizzo
Summary: Emerging data suggest that sub-clinical, non-convulsive epileptiform activity is prevalent in Alzheimer's disease (AD) and can be detected early in the disease. It is also correlated with cognitive decline in both humans and animal models. Epileptiform activity and electroencephalographic (EEG) measures have untapped potential to enhance the translational validity of AD-related biomarkers in animal models.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Correction
Geriatrics & Gerontology
Kevin P. Kotredes, Adrian Oblak, Ravi S. Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet Williams, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary Cope, Kate E. Foley, Benjamin A. Logsdon, Lara M. Mangravite, Stacey J. Sukoff Rizzo, Paul R. Territo, Gregory W. Carter, Michael Sasner, Bruce T. Lamb, Gareth R. Howell
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Hematology
Selen C. Muratoglu, Marc F. Charette, Zorina S. Galis, Adam S. Greenstein, Alan Daugherty, Anne Joutel, Beth A. Kozel, Donna M. Wilcock, Emily C. Collins, Farzaneh A. Sorond, Gareth R. Howell, Hyacinth I. Hyacinth, Kent K. C. Lloyd, Kurt R. Stenmark, Manfred Boehm, Mark L. Kahn, Roderick Corriveau, Sara Wells, Timothy J. Bussey, Stacey J. Sukoff Rizzo, M. Luisa Iruela-Arispe
Summary: Clinical investigations have shown that vascular-associated medical conditions are significant risk factors for dementia. However, the specific cognitive impairments associated with certain types of vascular deficiencies are still unclear. To address this, the National Heart, Lung, and Blood Institute has developed animal models to study vascular disease and its underlying causes. These models could be used as tools to link specific vascular signaling pathways with cognitive and neurobehavioral deficits related to dementia.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Adrian L. Oblak, Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Cynthia Ingraham, Bridget Perkins, Christopher Lloyd, Deborah Baker, Peter B. Lin, Disha M. Soni, Andy P. Tsai, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Jill A. Meyer, Johnathan S. Peters, Lucas L. Figueiredo, Michael Sasner, Paul R. Territo, Stacey J. Sukoff Rizzo, Gregory W. Carter, Bruce T. Lamb, Gareth R. Howell
Summary: Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). This study evaluated the impact of genetic risk factors on late-onset AD in mice fed with a high fat/high sugar diet and found a correlation between obesity and late-onset AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Sarah A. A. Schoenrock, Leona Gagnon, Ashley Olson, Michael Leonardo, Vivek M. M. Philip, Hao He, Laura G. G. Reinholdt, Stacey J. Sukoff J. Rizzo, James D. D. Jentsch, Elissa J. J. Chesler, Lisa M. M. Tarantino
Summary: The use of cocaine and overdose deaths related to cocaine have increased in the United States in the past decade. Despite the lack of approved treatments for cocaine use disorder (CUD), genetic studies in mice have provided valuable insights into its etiology. This study used a 19-day protocol to measure cocaine-induced behavioral sensitization in genetically diverse mouse strains, identifying significant differences in cocaine sensitivity and sensitization. These behaviors exhibited robust heritability, suggesting they can be utilized in future genetic mapping studies and the development of novel therapeutics.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Michael Sasner, Paul R. Territo, Stacey J. Sukoff J. Rizzo
Summary: The second annual workshop on improving preclinical to clinical translation in Alzheimer's Disease Research provided participants with skills and knowledge to perform preclinical experiments and improve translational studies for AD. The workshop included lectures, hands-on training, and participants from various research stages and regions.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Erwan Bezard, David Gray, Rouba Kozak, Matthew Leoni, Cari Combs, Sridhar Duvvuri
Summary: Currently available therapeutics for PD do not provide sustained and predictable relief from motor symptoms without significant adverse events (AEs). There is a need for a treatment that can effectively relieve motor symptoms with reduced risk of AEs.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Editorial Material
Behavioral Sciences
Stacey J. Sukoff Rizzo
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Geriatrics & Gerontology
Stacey J. Sukoff Rizzo, Toren Finkel, Susan L. Greenspan, Neil M. Resnick, Jennifer S. Brach
Summary: Research on aging is at a crucial stage where findings in basic biology can be applied to improve health span and longevity. The collaboration of researchers from various disciplines is essential in identifying new biomarkers, therapeutic targets, and assessing the efficacy of interventions. The ultimate goal is to conduct clinical trials of novel agents to extend health span and lifespan.
INNOVATION IN AGING
(2023)
Article
Clinical Neurology
Kristen D. Onos, Sara K. Quinney, David R. Jones, Andrea R. Masters, Ravi Pandey, Kelly J. Keezer, Carla Biesdorf, Ingrid F. Metzger, Jill A. Meyers, Johnathon Peters, Scott C. Persohn, Brian P. McCarthy, Amanda A. Bedwell, Lucas L. Figueiredo, Zackary A. Cope, Michael Sasner, Gareth R. Howell, Harriet M. Williams, Adrian L. Oblak, Bruce T. Lamb, Gregory W. Carter, Stacey J. Sukoff Rizzo, Paul R. Territo
Summary: This study investigates the pharmacokinetic/pharmacodynamic (PK/PD) relationship of levetiracetam (LEV) in an amyloidogenic mouse model of Alzheimer's disease (AD). The results demonstrate non-linear kinetics based on dose and sex, with significant sex differences in the pharmacokinetics of LEV observed in 5XFAD mice. Additionally, gene expression changes relevant to human AD were found to be dose-related and aligned with regional changes in glucose uptake. The study highlights the importance of PK/PD relationships in preclinical studies to inform clinical study design.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Article
Clinical Neurology
Adrian L. Oblak, Zackary A. Cope, Sara K. Quinney, Ravi S. Pandey, Carla Biesdorf, Andi R. Masters, Kristen D. Onos, Leslie Haynes, Kelly J. Keezer, Jill A. Meyer, Jonathan S. Peters, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Gabriela Little, Sean-Paul Williams, Brenda Noarbe, Andre Obenaus, Michael Sasner, Gareth R. Howell, Gregory W. Carter, Harriet Williams, Bruce T. Lamb, Paul R. Territo, Stacey J. Sukoff Rizzo
Summary: This study aimed to evaluate the effectiveness of BACE inhibitor verubecestat as a prophylactic treatment for early-stage Alzheimer's disease. The results showed that prophylactic use of verubecestat could reduce amyloid plaque deposition in 5XFAD mice and decrease plasma levels of amyloid beta. However, some side effects were observed within the dosage range, and no improvement in cognitive function was observed.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Article
Health Care Sciences & Services
Husam Albarmawi, Shujia Zhou, Lisa M. Shulman, Aakash Bipin Gandhi, Abree Johnson, Daniela E. Myers, David Gray, Jose Alvir, Eberechukwu Onukwugha
Summary: Among Medicare beneficiaries, Parkinson's Disease is associated with excess costs compared with controls. We did not identify substantial differences in the incremental cost of Parkinson's Disease across different survival groups.
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY
(2022)
Article
Medicine, Research & Experimental
Rahul Sasane, Amy Bartels, Michelle Field, Maria I. Sierra, Sridhar Duvvuri, David L. Gray, Sokhom S. Pin, John J. Renger, David J. Stone
Summary: The study found that tamsulosin users had a significantly higher incidence of Parkinson's disease compared to terazosin/alfuzosin/doxazosin users and matched controls. There was no significant difference in Parkinson's disease risk between terazosin/alfuzosin/doxazosin users and matched controls. These results suggest that tamsulosin may exacerbate Parkinson's disease progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)