Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy
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Title
Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy
Authors
Keywords
Diabetic cardiomyopathy, Trimetazidine, Autophagy, Myocardial fibrosis, Apoptosis
Journal
Journal of Translational Medicine
Volume 14, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-04-27
DOI
10.1186/s12967-016-0849-1
References
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Related references
Note: Only part of the references are listed.- Autophagy and mitophagy in diabetic cardiomyopathy
- (2015) Satoru Kobayashi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways
- (2014) Karina Huynh et al. PHARMACOLOGY & THERAPEUTICS
- Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy
- (2013) Rui Guo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The metabolic modulator trimetazidine triggers autophagy and counteracts stress-induced atrophy in skeletal muscle myotubes
- (2013) Elisabetta Ferraro et al. FEBS Journal
- Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
- (2012) Chun-jun Li et al. Cardiovascular Diabetology
- Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia
- (2012) Sebastiano Sciarretta et al. CIRCULATION
- Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3K -Akt-AS160 in Skeletal Muscle Cells
- (2012) C. Osorio-Fuentealba et al. DIABETES
- Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
- (2012) C. He et al. DIABETES
- Trimetazidine Protects against Smoking-Induced Left Ventricular Remodeling via Attenuating Oxidative Stress, Apoptosis, and Inflammation
- (2012) Xiang Zhou et al. PLoS One
- Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation
- (2012) Xihui Xu et al. Journal of Molecular Cell Biology
- TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model
- (2011) Yun Ti et al. DIABETES
- Trimetazidine inhibits pressure overload-induced cardiac fibrosis through NADPH oxidase–ROS–CTGF pathway
- (2010) Xuehui Liu et al. CARDIOVASCULAR RESEARCH
- Deficiency of Nectin-2 Leads to Cardiac Fibrosis and Dysfunction Under Chronic Pressure Overload
- (2009) Seimi Satomi-Kobayashi et al. HYPERTENSION
- Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes
- (2009) Daniel J. Fazakerley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Chronic Inhibition of Nitric Oxide on Hypertension, Insulin Resistance, and Cardiovascular Remodeling in Glucose-fed Rats
- (2009) Magalie Pilon et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options
- (2008) Ashish Aneja et al. AMERICAN JOURNAL OF MEDICINE
- Insulin signalling in the heart
- (2008) L. Bertrand et al. CARDIOVASCULAR RESEARCH
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