Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

Development of the Cardiac Conduction System

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Transcriptional Patterning of the Ventricular Cardiac Conduction System

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Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

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Conserved NPPB+ Border Zone Switches from MEF2 to AP-1 Driven Gene Program

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JASPAR 2020: update of the open-access database of transcription factor binding profiles

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The Post-GWAS Era: From Association to Function

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Relationship between QRS duration and incident atrial fibrillation

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Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system

(2018) Julia Ramírez et al.   Nature Communications

Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

(2018) Niek Verweij et al.   Nature Communications

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

(2018) Jessica van Setten et al.   Nature Communications

Enhancer redundancy provides phenotypic robustness in mammalian development

(2018) Marco Osterwalder et al.   NATURE

Resolving systematic errors in widely used enhancer activity assays in human cells

(2017) Felix Muerdter et al.   NATURE METHODS

HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development

(2017) Frédéric Laurent et al.   Cell Reports

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis

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The Genetics of Transcription Factor DNA Binding Variation

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Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

(2016) Hannah K. Long et al.   CELL

Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks

(2016) Enrico Cannavò et al.   CURRENT BIOLOGY

Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes

(2016) Sakthi D. Moorthy et al.   GENOME RESEARCH

52 Genetic Loci Influencing Myocardial Mass

(2016) Pim van der Harst et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

(2016) Stephanie I Protze et al.   NATURE BIOTECHNOLOGY

Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution

(2016) Cosmas D Arnold et al.   NATURE BIOTECHNOLOGY

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

(2016) Xinchen Wang et al.   eLife

Genomics of Atrial Fibrillation

(2016) Alejandra Gutierrez et al.   Current Cardiology Reports

LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants: Fig. 1.

(2015) Mitchell J. Machiela et al.   BIOINFORMATICS

Decoding enhancers using massively parallel reporter assays

(2015) Fumitaka Inoue et al.   GENOMICS

CTCF Binding Polarity Determines Chromatin Looping

(2015) Elzo de Wit et al.   MOLECULAR CELL

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells

(2015) Matthew J Birket et al.   NATURE BIOTECHNOLOGY

Sound of silence: the properties and functions of repressive Lys methyltransferases

(2015) Chiara Mozzetta et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures

(2015) Karel van Duijvenboden et al.   NUCLEIC ACIDS RESEARCH

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

(2015) Christian Rimmbach et al.   Jove-Journal of Visualized Experiments

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

A Large Permissive Regulatory Domain Exclusively Controls Tbx3 Expression in the Cardiac Conduction System

(2014) Jan Hendrik van Weerd et al.   CIRCULATION RESEARCH

Genetic Determinants of P Wave Duration and PR Segment

(2014) N. Verweij et al.   Circulation-Cardiovascular Genetics

Further confirmation of the MED13L haploinsufficiency syndrome

(2014) Mieke M van Haelst et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Enhancer–core-promoter specificity separates developmental and housekeeping gene regulation

(2014) Muhammad A. Zabidi et al.   NATURE

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

(2014) Ralf Gilsbach et al.   Nature Communications

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development

(2014) Sonia Stefanovic et al.   Nature Communications

Enhancer variants: evaluating functions in common disease

(2014) Olivia Corradin et al.   Genome Medicine

Programming and Isolation of Highly Pure Physiologically and Pharmacologically Functional Sinus-Nodal Bodies from Pluripotent Stem Cells

(2014) Julia Jeannine Jung et al.   Stem Cell Reports

Rapid and Pervasive Changes in Genome-wide Enhancer Usage during Mammalian Development

(2013) Alex S. Nord et al.   CELL

Dosage changes of MED13L further delineate its role in congenital heart defects and intellectual disability

(2013) Reza Asadollahi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seq

(2013) C. D. Arnold et al.   SCIENCE

Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b

(2013) Timo H-W. Lüdtke et al.   PLoS Genetics

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells

(2012) Martijn L. Bakker et al.   CARDIOVASCULAR RESEARCH

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration

(2012) Bas J. Boukens et al.   CARDIOVASCULAR RESEARCH

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

TBX5 drives Scn5a expression to regulate cardiac conduction system function

(2012) David E. Arnolds et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficient TALEN-mediated gene knockout in livestock

(2012) D. F. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation

(2011) Reena Singh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) T. Cermak et al.   NUCLEIC ACIDS RESEARCH

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

(2011) D. U. Frank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BEDTools: a flexible suite of utilities for comparing genomic features

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Developmental Origin, Growth, and Three-Dimensional Architecture of the Atrioventricular Conduction Axis of the Mouse Heart

(2010) Wim T.J. Aanhaanen et al.   CIRCULATION RESEARCH

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

(2010) Nona Sotoodehnia et al.   NATURE GENETICS

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

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Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Gene Expression Profiling of the Forming Atrioventricular Node Using a Novel Tbx3 -Based Node-Specific Transgenic Reporter

(2009) Thomas Horsthuis et al.   CIRCULATION RESEARCH

Long-term Outcomes in Individuals With Prolonged PR Interval or First-Degree Atrioventricular Block

(2009) Susan Cheng   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH

Transcription Factor Tbx3 Is Required for the Specification of the Atrioventricular Conduction System

(2008) Martijn L. Bakker et al.   CIRCULATION RESEARCH

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

(2008) Timo H.-W. Lüdtke et al.   HEPATOLOGY

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS