Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

Transcriptional regulation of the cardiac conduction system

(2018) Vincent W. W. van Eif et al.   Nature Reviews Cardiology

Embryonic Tbx3+cardiomyocytes form the mature cardiac conduction system by progressive fate restriction

(2018) Rajiv A. Mohan et al.   DEVELOPMENT

Next-generation pacemakers: from small devices to biological pacemakers

(2017) Eugenio Cingolani et al.   Nature Reviews Cardiology

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

(2016) Stephanie I Protze et al.   NATURE BIOTECHNOLOGY

RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells

(2015) V. Vedantham et al.   CIRCULATION RESEARCH

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

(2015) W. Ye et al.   DEVELOPMENT

Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current

(2015) Arie Verkerk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcription factor ISL1 is essential for pacemaker development and function

(2015) Xingqun Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

The past, present, and future of pacemaker therapies

(2015) Gerard J.J. Boink et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Insights into cardiac conduction system formation provided by HCN4 expression

(2015) Xingqun Liang et al.   TRENDS IN CARDIOVASCULAR MEDICINE

HCN4 Mutations in Multiple Families With Bradycardia and Left Ventricular Noncompaction Cardiomyopathy

(2014) Annalisa Milano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia

(2013) Sandra Hoffmann et al.   BASIC RESEARCH IN CARDIOLOGY

A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease

(2013) Irina A. Sergeeva et al.   CARDIOVASCULAR RESEARCH

HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors

(2013) Xingqun Liang et al.   CIRCULATION RESEARCH

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

(2013) Marcel den Hoed et al.   NATURE GENETICS

Early Mesodermal Cues Assign Avian Cardiac Pacemaker Fate Potential in a Tertiary Heart Field

(2013) M. Bressan et al.   SCIENCE

Shox2 Regulates the Pacemaker Gene Program in Embryoid Bodies

(2013) Sherin I. Hashem et al.   STEM CELLS AND DEVELOPMENT

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells

(2012) Martijn L. Bakker et al.   CARDIOVASCULAR RESEARCH

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration

(2012) Bas J. Boukens et al.   CARDIOVASCULAR RESEARCH

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Identification and Functional Characterization of Cardiac Pacemaker Cells in Zebrafish

(2012) Federico Tessadori et al.   PLoS One

Homozygosity Mapping and Candidate Prioritization Identify Mutations, Missed by Whole-Exome Sequencing, in SMOC2, Causing Major Dental Developmental Defects

(2011) Agnès Bloch-Zupan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation

(2011) Reena Singh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt/β-Catenin Signaling Maintains the Mesenchymal Precursor Pool for Murine Sinus Horn Formation

(2011) Julia Norden et al.   CIRCULATION RESEARCH

Molecular Analysis of Patterning of Conduction Tissues in the Developing Human Heart

(2011) Aleksander Sizarov et al.   Circulation-Arrhythmia and Electrophysiology

Hox genes define distinct progenitor sub-domains within the second heart field

(2011) Nicolas Bertrand et al.   DEVELOPMENTAL BIOLOGY

The expression of Visinin-like 1 during mouse embryonic development

(2011) Roxana Ola et al.   GENE EXPRESSION PATTERNS

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

(2011) D. U. Frank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The sinus venosus progenitors separate and diversify from the first and second heart fields early in development

(2010) Mathilda T.M. Mommersteeg et al.   CARDIOVASCULAR RESEARCH

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

Contactin-2 Expression in the Cardiac Purkinje Fiber Network

(2010) Benedetta A. Pallante et al.   Circulation-Arrhythmia and Electrophysiology

Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart

(2010) Sandra Puskaric et al.   HUMAN MOLECULAR GENETICS

Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate

(2009) Daniel Gros et al.   CARDIOVASCULAR RESEARCH

Molecular Architecture of the Human Sinus Node

(2009) Natalie J. Chandler et al.   CIRCULATION

Gene Expression Profiling of the Forming Atrioventricular Node Using a Novel Tbx3 -Based Node-Specific Transgenic Reporter

(2009) Thomas Horsthuis et al.   CIRCULATION RESEARCH

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5

(2009) Ramón A. Espinoza-Lewis et al.   DEVELOPMENTAL BIOLOGY

Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling

(2009) Joshua S. Waxman et al.   DEVELOPMENTAL DYNAMICS

Pacemaker activity of the human sinoatrial node: Role of the hyperpolarization-activated current, If

(2009) Arie O. Verkerk et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Tbx3 Is Required for Outflow Tract Development

(2008) Karim Mesbah et al.   CIRCULATION RESEARCH

Transcription Factor Tbx3 Is Required for the Specification of the Atrioventricular Conduction System

(2008) Martijn L. Bakker et al.   CIRCULATION RESEARCH

Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3

(2008) Cornelia Wiese et al.   CIRCULATION RESEARCH

Atrial Remodeling and Atrial Fibrillation

(2008) Stanley Nattel et al.   Circulation-Arrhythmia and Electrophysiology

Hoxb5b Acts Downstream of Retinoic Acid Signaling in the Forelimb Field to Restrict Heart Field Potential in Zebrafish

(2008) Joshua S. Waxman et al.   DEVELOPMENTAL CELL

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

(2008) Timo H.-W. Lüdtke et al.   HEPATOLOGY

Retinoic acid in development: towards an integrated view

(2008) Karen Niederreither et al.   NATURE REVIEWS GENETICS

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS

Retinoic acid deficiency alters second heart field formation

(2008) L. Ryckebusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA