Hepatitis C virus exploits cyclophilin A to evade PKR

The search for a PKR code — Differential regulation of Protein Kinase R activity by diverse RNA and protein regulators

(2019) Charles Bou-Nader et al.   RNA

Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus

(2019) Jenna M Gaska et al.   eLife

Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses

(2019) Daisuke Yamane et al.   Nature Microbiology

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

(2019) Kyusik Kim et al.   Nature Microbiology

Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20

(2018) Junjie Feng et al.   JOURNAL OF VIROLOGY

Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle

(2018) Richard L. Mackman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

(2017) Wei Liu et al.   eLife

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

(2016) Christopher J. Neufeldt et al.   PLoS Pathogens

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap

(2016) Marianne Ngure et al.   ACS Infectious Diseases

Cyclophilin and NS5A Inhibitors, but Not Other Anti-Hepatitis C Virus (HCV) Agents, Preclude HCV-Mediated Formation of Double-Membrane-Vesicle Viral Factories

(2015) Udayan Chatterji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

TRIM5  requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

(2015) A. J. Fletcher et al.   EMBO JOURNAL

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

(2015) Justin Warne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A

(2015) Marie-Sophie Hiet et al.   JOURNAL OF HEPATOLOGY

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

(2015) Inés Romero-Brey et al.   mBio

Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus

(2015) Silke Bender et al.   PLoS Pathogens

Cyclophilin Inhibitors Reduce Phosphorylation of RNA-Dependent Protein Kinase to Restore Expression of IFN-Stimulated Genes in HCV-Infected Cells

(2014) Takuji Daito et al.   GASTROENTEROLOGY

Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus–Induced Membranous Replication Factories, Independent of RNA Replication

(2014) Carola Berger et al.   GASTROENTEROLOGY

Inhibition of HCV Replication by Cyclophilin Antagonists Is Linked to Replication Fitness and Occurs by Inhibition of Membranous Web Formation

(2014) Vanesa Madan et al.   GASTROENTEROLOGY

Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!

(2014) D. Ross-Thriepland et al.   JOURNAL OF GENERAL VIROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Cyclophilin A (CypA) Interacts with NF-κB Subunit, p65/RelA, and Contributes to NF-κB Activation Signaling

(2014) Shan Sun et al.   PLoS One

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Hepatitis C virus infection enhances TNFα-induced cell death via suppression of NF-κB

(2012) Junseong Park et al.   HEPATOLOGY

The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

(2012) Sam Hopkins et al.   JOURNAL OF HEPATOLOGY

Hepatitis C Virus NS5A Disrupts STAT1 Phosphorylation and Suppresses Type I Interferon Signaling

(2012) Kattareeya Kumthip et al.   JOURNAL OF VIROLOGY

Suppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles In Vitro by Cyclophilin Inhibitors

(2012) A. Nag et al.   JOURNAL OF VIROLOGY

Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication

(2012) Inés Romero-Brey et al.   PLoS Pathogens

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A

(2011) Karla J. Helbig et al.   HEPATOLOGY

Cyclosporin A inhibits the replication of diverse coronaviruses

(2011) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33

(2011) S. Wang et al.   JOURNAL OF GENERAL VIROLOGY

Cyclophilin A Interacts with Domain II of Hepatitis C Virus NS5A and Stimulates RNA Binding in an Isomerase-Dependent Manner

(2011) T. L. Foster et al.   JOURNAL OF VIROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion

(2011) Leah J Anderson et al.   Virology Journal

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

(2010) Tara L. Davis et al.   PLOS BIOLOGY

A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach

(2010) Feng Yang et al.   PLoS Pathogens

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein

(2009) M. Qing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolylcis/transIsomerase Activity of Cyclophilins A and B

(2009) Xavier Hanoulle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

(2009) Udayan Chatterji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

(2009) Z. Liu et al.   JOURNAL OF VIROLOGY

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

(2009) Artur Kaul et al.   PLoS Pathogens

Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

(2008) F. Yang et al.   JOURNAL OF VIROLOGY

Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

(2008) L. M. J. Ylinen et al.   JOURNAL OF VIROLOGY