Uremic Toxins and Vascular Dysfunction

Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition

(2020) Emiko Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression

(2019) Karim Belmokhtar et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease

(2019) Pei-Chun Fan et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Direct Impairment of the Endothelial Function by Acute Indoxyl Sulfate through Declined Nitric Oxide and Not Endothelium-Derived Hyperpolarizing Factor or Vasodilator Prostaglandins in the Rat Superior Mesenteric Artery

(2019) Takayuki Matsumoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Association between Serum Indoxyl Sulfate Levels and Endothelial Function in Non-Dialysis Chronic Kidney Disease

(2019) Chih-Hsien Wang et al.   Toxins

Vascular smooth muscle contraction in hypertension

(2018) Rhian M Touyz et al.   CARDIOVASCULAR RESEARCH

Protein-bounded uremic toxin p-cresylsulfate induces vascular permeability alternations

(2018) Wei-Hua Tang et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Protein carbamylation exacerbates vascular calcification

(2018) Daisuke Mori et al.   KIDNEY INTERNATIONAL

Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update

(2018) Raymond Vanholder et al.   Toxins

FGF23 Actions on Target Tissues—With and Without Klotho

(2018) Beatrice Richter et al.   Frontiers in Endocrinology

Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions

(2018) Rayana Maciel et al.   Toxins

Urea Memory: Transient Cell Exposure to Urea Causes Persistent Mitochondrial ROS Production and Endothelial Dysfunction

(2018) Maria d’Apolito et al.   Toxins

Urea and chronic kidney disease: the comeback of the century? (in uraemia research)

(2017) Raymond Vanholder et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

p-Cresyl Sulfate

(2017) Tessa Gryp et al.   Toxins

Microvesicles Derived from Indoxyl Sulfate Treated Endothelial Cells Induce Endothelial Progenitor Cells Dysfunction

(2017) Andres Carmona et al.   Frontiers in Physiology

Beta-Glucans Supplementation Associates with Reduction in P-Cresyl Sulfate Levels and Improved Endothelial Vascular Reactivity in Healthy Individuals

(2017) Carmela Cosola et al.   PLoS One

Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging

(2016) Jennifer S. Yokoyama et al.   Brain Imaging and Behavior

Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase ActivityNovelty and Significance

(2016) Diansa Gao et al.   HYPERTENSION

Indoxyl Sulfate Impairs Endothelial Progenitor Cells and Might Contribute to Vascular Dysfunction in Patients with Chronic Kidney Disease

(2016) Cheng-Jui Lin et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Update on FGF23 and Klotho signaling

(2016) Reinhold G. Erben   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Atorvastatin attenuates p-cresyl sulfate-induced atherogenesis and plaque instability in ApoE knockout mice

(2016) Hui Han et al.   Molecular Medicine Reports

Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells

(2016) Beatrice Richter et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Reconsidering the Lack of Urea Toxicity in Dialysis Patients

(2016) Ziad A. Massy et al.   SEMINARS IN DIALYSIS

AST-120 Improves Microvascular Endothelial Dysfunction in End-Stage Renal Disease Patients Receiving Hemodialysis

(2016) Jung-Hwa Ryu et al.   YONSEI MEDICAL JOURNAL

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

(2016) C-C Hsieh et al.   Aging-US

Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway

(2015) Wen-Ching Shen et al.   ARCHIVES OF TOXICOLOGY

Fibroblast Growth Factor 23 Is Associated With Carotid Plaque Presence and AreaSignificance

(2015) Nirav H. Shah et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Urea-induced ROS cause endothelial dysfunction in chronic renal failure

(2015) Maria D'Apolito et al.   ATHEROSCLEROSIS

Deleterious vascular effects of indoxyl sulfate and reversal by oral adsorbent AST-120

(2015) Isabelle Six et al.   ATHEROSCLEROSIS

Haplodeficiency ofKlothoGene Causes Arterial Stiffening via Upregulation of Scleraxis Expression and Induction of AutophagyNovelty and Significance

(2015) Kai Chen et al.   HYPERTENSION

Para-cresyl sulfate acutely impairs vascular reactivity and induces vascular remodeling

(2015) Priscilla Gross et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Renal Production, Uptake, and Handling of Circulating  Klotho

(2015) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Indoxyl Sulfate-Induced Oxidative Stress, Mitochondrial Dysfunction, and Impaired Biogenesis Are Partly Protected by Vitamin C and N-Acetylcysteine

(2015) Wen-Chin Lee et al.   TheScientificWorldJOURNAL

Exploring Protein Binding of Uremic Toxins in Patients with Different Stages of Chronic Kidney Disease and during Hemodialysis

(2015) Olivier Deltombe et al.   Toxins

Indoxyl Sulfate-Induced Oxidative Stress, Mitochondrial Dysfunction, and Impaired Biogenesis Are Partly Protected by Vitamin C and N-Acetylcysteine

(2015) Wen-Chin Lee et al.   Scientific World Journal

Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure

(2015) Cheng-Jui Lin et al.   PLoS One

FGF23 directly impairs endothelium-dependent vasorelaxation by increasing superoxide levels and reducing nitric oxide bioavailability

(2014) Neerupma Silswal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho

(2014) Ci-Di Chen et al.   BIOCHEMISTRY

Associations of FGF-23 and sKlotho with Cardiovascular Outcomes among Patients with CKD Stages 2-4

(2014) S. Seiler et al.   Clinical Journal of the American Society of Nephrology

The Uremic Toxicity of Indoxyl Sulfate and p-Cresyl Sulfate: A Systematic Review

(2014) R. Vanholder et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association of plasma levels of soluble receptor for advanced glycation end products and risk of kidney disease: the Atherosclerosis Risk in Communities study

(2014) Casey M. Rebholz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Direct, Acute Effects of Klotho and FGF23 on Vascular Smooth Muscle and Endothelium

(2014) Isabelle Six et al.   PLoS One

Circulating α-Klotho Levels in CKD and Relationship to Progression

(2013) Hyoung Rae Kim et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

A novel UPLC–MS–MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients

(2013) Jente Boelaert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Reference ranges and biological variation of free and total serum indoxyl- and p-cresyl sulphate measured with a rapid UPLC fluorescence detection method

(2013) Carel J. Pretorius et al.   CLINICA CHIMICA ACTA

Human organic anion transporters function as a high-capacity transporter for p-cresyl sulfate, a uremic toxin

(2013) Hiroshi Watanabe et al.   Clinical and Experimental Nephrology

Serum FGF23 and Risk of Cardiovascular Events in Relation to Mineral Metabolism and Cardiovascular Pathology

(2013) J. Arnlov et al.   Clinical Journal of the American Society of Nephrology

Disordered FGF23 and Mineral Metabolism in Children with CKD

(2013) A. A. Portale et al.   Clinical Journal of the American Society of Nephrology

FGF23 and Klotho in chronic kidney disease

(2013) Hannes Olauson et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-like Receptor-2

(2013) Thimoteus Speer et al.   IMMUNITY

Effects of sevelamer treatment on cardiovascular abnormalities in mice with chronic renal failure

(2013) Julien Maizel et al.   KIDNEY INTERNATIONAL

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

(2013) Masashi Kitagawa et al.   PLoS One

Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function

(2013) Karolina Lindberg et al.   PLoS One

Quantification of p-cresol sulphate in human plasma by selected reaction monitoring

(2012) Aurora Cuoghi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Effects of phosphate on vascular function under normal conditions and influence of the uraemic state

(2012) I. Six et al.   CARDIOVASCULAR RESEARCH

The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor

(2012) Armando Rojas et al.   CELLULAR SIGNALLING

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Fibroblast Growth Factor-23 and Death, Heart Failure, and Cardiovascular Events in Community-Living Individuals

(2012) Joachim H. Ix et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Uremic solutes from colon microbes

(2012) Timothy W. Meyer et al.   KIDNEY INTERNATIONAL

Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community

(2012) Johan Ärnlöv et al.   KIDNEY INTERNATIONAL

High phosphate directly affects endothelial function by downregulating annexin II

(2012) Giovana Seno Di Marco et al.   KIDNEY INTERNATIONAL

Klotho modulates the stress response in human senescent endothelial cells

(2012) Julia Carracedo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Measurement of serum soluble Klotho levels in CKD 5D patients: useful tool or dispensable biomarker?

(2012) D. Fliser et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hemodialysis Removes Uremic Toxins That Alter the Biological Actions of Endothelial Cells

(2012) Kalliopi Zafeiropoulou et al.   PLoS One

Mechanisms of Endothelial Dysfunction in Resistance Arteries from Patients with End-Stage Renal Disease

(2012) Leanid Luksha et al.   PLoS One

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

(2012) Jian Xie et al.   Nature Communications

S-Glutathionylation Reshapes Our Understanding of Endothelial Nitric Oxide Synthase Uncoupling and Nitric Oxide/Reactive Oxygen Species-Mediated Signaling

(2011) Jay L. Zweier et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation

(2011) Sourabh Kharait et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Upregulation of BAD, a pro-apoptotic protein of the BCL2 family, in vascular smooth muscle cells exposed to uremic conditions

(2011) Eric Trécherel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Reactive Oxygen Species/Extracellular Signal-Regulated Kinases Pathway by Pioglitazone Attenuates Advanced Glycation End Products-Induced Proliferation of Vascular Smooth Muscle Cells in Rats

(2011) Xiaochen Yuan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

p-cresylsulfate and indoxyl sulfate level at different stages of chronic kidney disease

(2011) Cheng-Jui Lin et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Plasma Klotho and Cardiovascular Disease in Adults

(2011) Richard D. Semba et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Warning: the unfortunate end of p-cresol as a uraemic toxin

(2011) R. Vanholder et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages

(2011) L. Desjardins et al.   OSTEOPOROSIS INTERNATIONAL

Adverse Effects of Simulated Hyper- and Hypo-Phosphatemia on Endothelial Cell Function and Viability

(2011) Ai Peng et al.   PLoS One

Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-Induced NF-ĸB Activation

(2010) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke

(2010) Vijaya Majumdar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Indoxyl Sulfate Stimulates Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells by Inducing Oxidative Stress Through Activation of the NADPH Oxidase-Nuclear Factor-κB Pathway

(2010) Natsumi Masai et al.   CIRCULATION JOURNAL

Symmetrical and Asymmetrical Dimethylarginine as Predictors for Mortality in Patients Referred for Coronary Angiography: The Ludwigshafen Risk and Cardiovascular Health Study

(2010) A. Meinitzer et al.   CLINICAL CHEMISTRY

Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress

(2010) M. Yu et al.   Clinical Journal of the American Society of Nephrology

Dysfunctional Endothelial Progenitor Cells in Chronic Kidney Disease

(2010) M. S. Goligorsky et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Uremic Retention Solute p-Cresyl Sulfate and Markers of Endothelial Damage

(2009) Björn K.I. Meijers et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Indoxyl Sulfate Inhibits Nitric Oxide Production and Cell Viability by Inducing Oxidative Stress in Vascular Endothelial Cells

(2009) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community

(2009) Majd A.I. Mirza et al.   ATHEROSCLEROSIS

Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population

(2009) Majd A.I. Mirza et al.   ATHEROSCLEROSIS

Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2

(2009) Qin Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products

(2009) Chun Liang et al.   BRITISH JOURNAL OF PHARMACOLOGY

A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries

(2009) Karen L Andrews et al.   BRITISH JOURNAL OF PHARMACOLOGY

Soluble Guanylate Cyclase

(2009) Guido Boerrigter et al.   CIRCULATION

Mechanisms of Aortic and Cardiac Dysfunction in Uremic Mice With Aortic Calcification

(2009) Julien Maizel et al.   CIRCULATION

Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease

(2009) Orlando M. Gutiérrez et al.   CIRCULATION

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

EDHF: an update

(2009) Michel Félétou et al.   CLINICAL SCIENCE

Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options

(2009) M P C Kao et al.   JOURNAL OF HUMAN HYPERTENSION

Dietary Phosphorus Acutely Impairs Endothelial Function

(2009) E. Shuto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced Glycation End Products Induce Calcification of Vascular Smooth Muscle Cells through RAGE/p38 MAPK

(2009) Takahisa Tanikawa et al.   JOURNAL OF VASCULAR RESEARCH

Relationship between circulating FGF23 and total body atherosclerosis in the community

(2009) Majd A. I. Mirza et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A 1-Year Randomized Trial of Calcium Acetate Versus Sevelamer on Progression of Coronary Artery Calcification in Hemodialysis Patients With Comparable Lipid Control: The Calcium Acetate Renagel Evaluation-2 (CARE-2) Study

(2008) Wajeh Qunibi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Impact of Immunosuppressive Treatment on Endothelial Biomarkers After Kidney Transplantation

(2008) G. Al-Massarani et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Advanced glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogen-activated protein kinase pathways

(2008) Chengbo Sun et al.   BASIC RESEARCH IN CARDIOLOGY

AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation

(2007) Weijing Cai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats

(2007) Heather Macarthur et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Short-Term Treatment with Sevelamer Increases Serum Fetuin-A Concentration and Improves Endothelial Dysfunction in Chronic Kidney Disease Stage 4 Patients

(2007) K. Caglar et al.   Clinical Journal of the American Society of Nephrology

Phosphate Is a Uremic Toxin

(2007) Steven K. Burke   JOURNAL OF RENAL NUTRITION