Article
Biochemistry & Molecular Biology
Ye Liu, Yan Duan, Nan Zhao, Xinxin Zhu, Xiaoting Yu, Shiyu Jiao, Yanting Song, Li Shi, Yutao Ma, Xia Wang, Baoqi Yu, Aijuan Qu
Summary: The study reveals that PPAR alpha plays a critical protective role in Ang II-induced hypertension by attenuating ROS production in VSMCs, providing a potential therapeutic target for hypertensive diseases.
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Biology
Catarina Teixeira, Andre P. Sousa, Ines Santos, Ana Catarina Rocha, Ines Alencastre, Ana Claudia Pereira, Daniela Martins-Mendes, Pedro Barata, Pilar Baylina, Ruben Fernandes
Summary: This study demonstrates that pioglitazone enhances adipocyte differentiation and secretome production, making it an excellent model for studying adiposity. The study also proposes an improved method for adipocyte secretome production, which can be used for experimental biology studies to understand the molecular mechanisms underlying the influence of adiposity on other cells.
Article
Pharmacology & Pharmacy
Rasool Haddadi, Mohammad Cheraghi-poor
Summary: This study investigated the analgesic and anti-inflammatory effects of naproxen and pioglitazone, and found that their combined treatment enhanced these effects. The involvement of PPAR-gamma receptor was also noted. Additionally, these drugs reduced the release of inflammatory cytokines and myeloperoxidase activity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Haoyang Zou, Yiyao Gong, Haiqing Ye, Cuiping Yuan, Tiezhu Li, Jie Zhang, Li Ren
Summary: This study summarizes the physiological importance and clinical significance of PPARs and reviews the experimental evidence that natural products mediate metabolic syndrome via PPARs. The majority of currently described natural compounds are mild PPAR-selective agonists with therapeutic effects that are equivalent to synthetic medicines but less harmful adverse effects. Conclusion: PPAR agonists can be combined with natural products to treat and prevent metabolic syndrome.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jie Yang, Xiao Yang, Yi-fei Zhang, Jia-ning Tian, Shi-cheng Fan, Yue Gao, Hui-lin Li, Cheng-hui Cai, Min Huang, Hui-chang Bi
Summary: In this study, it was found that activation of PPARa leads to hepatomegaly in mice, with hepatocyte hypertrophy around the central vein area and hepatocyte proliferation around the portal vein area. The study also revealed that the upregulation of PPARa targets is higher in the central vein area compared to the portal vein area, while the upregulation of proliferation-related proteins mainly occurs in the portal vein area. These findings provide new insights into the understanding of PPARa activation-induced liver enlargement and regeneration.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Ahmad Alhowail, Rawan Alsikhan, May Alsaud, Maha Aldubayan, Syed Imam Rabbani
Summary: Pioglitazone has potential in treating cognitive impairment, but its use is associated with cardiovascular risks and limited blood-brain barrier penetration. However, existing research demonstrates that pioglitazone improves inflammation, oxidative stress, amyloidogenesis, hypothyroidism, neurogenesis, synaptic plasticity, and mitochondrial function through activating PPAR receptors.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Li Xu, Jiang Wu, Yuan Liu, Gang Chen, Chao Ma, Hongrong Zhang
Summary: The study examined the potential impact of PPAR β/δ on CVS following SAH, revealing that PPAR β/δ can alleviate CVS by regulating the phenotypic switch of VSMCs after SAH. Activation of PPAR β/δ also improves the diameter of the basilar artery, reduces vascular wall thickness, decreases brain water content and brain swelling.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Chemistry, Medicinal
Enrico D'Aniello, Pietro Amodeo, Rosa Maria Vitale
Summary: This review provides an overview of discovery, optimization, and structure-activity relationship studies on PPAR modulators from marine sources, as well as the structural and computational studies that led to their identification and/or elucidation, and rationalization of their mechanisms of action.
Article
Pathology
Lin Du, Xinkai Qu, Haixia Zheng, Rujun Li, Jun Wang, Mingxing Chen, Pei Zhao, Zhengang Zhang, Kaizheng Gong
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Zhengang Zhang, Xinkai Qu, Yue Ni, Kai Zhang, Zhifeng Dong, Xiaochen Yan, Jianhua Qin, Hongguang Sun, Yongling Ding, Pei Zhao, Kaizheng Gong
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Cell Biology
Zhengang Zhang, Pei Zhao, Aihua Li, Xiaolei Lv, Yang Gao, Hongguang Sun, Yongling Ding, Jian Liu
MEDIATORS OF INFLAMMATION
(2009)
Article
Biochemistry & Molecular Biology
Zhengang Zhang, Jianhua Qun, Chunmei Cao, Jun Wang, Wei Li, Yong Wu, Lin Du, Pei Zhao, Kaizheng Gong
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Nanoscience & Nanotechnology
Wei Li, Kaizheng Gong, Yuan Ding, Birenda Chaurasiya, Yue Ni, Yong Wu, Pei Zhao, Yan Shen, Zhengang Zhang, Thomas J. Webster
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Review
Medicine, General & Internal
Yong Wu, Pei Zhao, Wei Li, Ming-Qiang Cao, Lin Du, Jian-Chang Chen
Article
Biochemistry & Molecular Biology
Jun Wang, Pei Zhao, Yang Gao, Fengyu Zhang, Xiaochen Yuan, Yungen Jiao, Kaizheng Gong
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2019)
Article
Cell Biology
Pei Zhao, Wenjing Zhou, Yanxia Zhang, Jingjing Li, Ye Zhao, Lihua Pan, Zhenya Shen, Weiqian Chen, Jie Hui
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)