Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice

(2020) Dieudonné Buh Kum et al.   Emerging Microbes & Infections

Novel DNA-launched Venezuelan equine encephalitis virus vaccine with rearranged genome

(2019) Irina Tretyakova et al.   VACCINE

Fractional-dose yellow fever vaccination

(2019) Leonardus G. Visser   CURRENT OPINION IN INFECTIOUS DISEASES

Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin

(2019) Hanne Huysmans et al.   Molecular Therapy-Nucleic Acids

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye

(2018) Dinesh Jaishankar et al.   Science Translational Medicine

Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity

(2018) Wooseong Lee et al.   Nature Communications

The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus

(2018) Wen-Yu Cheng et al.   Frontiers in Immunology

Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors

(2018) Dorothée Bardiot et al.   JOURNAL OF MEDICINAL CHEMISTRY

The reemergence of yellow fever

(2018) Alan D. T. Barrett   SCIENCE

Favipiravir inhibits in vitro Usutu virus replication and delays disease progression in an infection model in mice

(2018) Nidya A. Segura Guerrero et al.   ANTIVIRAL RESEARCH

A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

(2018) Dieudonné B. Kum et al.   npj Vaccines

Vaccination Challenges in Confronting the Resurgent Threat From Yellow Fever

(2017) Lin H. Chen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

(2017) Timothy Pepini et al.   JOURNAL OF IMMUNOLOGY

Responding to the threat of urban yellow fever outbreaks

(2017) Annelies Wilder-Smith et al.   LANCET INFECTIOUS DISEASES

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Live Attenuated Yellow Fever 17D Vaccine: A Legacy Vaccine Still Controlling Outbreaks In Modern Day

(2017) Natalie D. Collins et al.   Current Infectious Disease Reports

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

(2017) Justin Hall et al.   PLoS One

DNA-launched live-attenuated vaccines for biodefense applications

(2016) Peter Pushko et al.   Expert Review of Vaccines

Vaccination with Replication Deficient Adenovectors Encoding YF-17D Antigens Induces Long-Lasting Protection from Severe Yellow Fever Virus Infection in Mice

(2016) Maria R. Bassi et al.   PLoS Neglected Tropical Diseases

Clinical potential of electroporation for gene therapy and DNA vaccine delivery

(2015) Laure Lambricht et al.   Expert Opinion on Drug Delivery

Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells

(2015) Martijn A. Langereis et al.   JOURNAL OF VIROLOGY

An inactivated yellow fever 17DD vaccine cultivated in Vero cell cultures

(2015) Renata C. Pereira et al.   VACCINE

A DNA Vaccine against Yellow Fever Virus: Development and Evaluation

(2015) Milton Maciel et al.   PLoS Neglected Tropical Diseases

Molecular and immunological characterization of a DNA-launched yellow fever virus 17D infectious clone

(2014) X. Jiang et al.   JOURNAL OF GENERAL VIROLOGY

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

Inhibitors of the Interferon Response Enhance Virus Replication In Vitro

(2014) Claire E. Stewart et al.   PLoS One

Plasmid DNA initiates replication of yellow fever vaccine in vitro and elicits virus-specific immune response in mice

(2014) Irina Tretyakova et al.   VIROLOGY

The Second Messenger Phosphatidylinositol-5-Phosphate Facilitates Antiviral Innate Immune Signaling

(2013) Takumi Kawasaki et al.   Cell Host & Microbe

The Non-Canonical IκB Kinases IKKε and TBK1 as Potential Targets for the Development of Novel Therapeutic Drugs

(2013) E. Niederberger et al.   CURRENT MOLECULAR MEDICINE

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

Dynamic Viral Dissemination in Mice Infected with Yellow Fever Virus Strain 17D

(2013) A. K. Erickson et al.   JOURNAL OF VIROLOGY

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1

(2013) Daqi Tu et al.   Cell Reports

Simple and inexpensive three-step rapid amplification of cDNA 5′ ends using 5′ phosphorylated primers

(2012) Kai Dallmeier et al.   ANALYTICAL BIOCHEMISTRY

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells

(2011) K A Monaghan et al.   LEUKEMIA

An Inactivated Cell-Culture Vaccine against Yellow Fever

(2011) Thomas P. Monath et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pre-Clinical Efficacy and Safety of Experimental Vaccines Based on Non-Replicating Vaccinia Vectors against Yellow Fever

(2011) Birgit Schäfer et al.   PLoS One

A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro

(2010) S. J. F. Kaptein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

(2010) J. W. Tyner et al.   BLOOD

Is Computed Tomography Safe?

(2010) Rebecca Smith-Bindman   NEW ENGLAND JOURNAL OF MEDICINE

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY