Calcium-Sensing Receptor Mediates β-Amyloid-Induced Synaptic Formation Impairment and Cognitive Deficits via Regulation of Cytosolic Phospholipase A2/Prostaglandin E2 Metabolic Pathway

p-Hydroxybenzyl Alcohol Prevents Memory Deficits by Increasing Neurotrophic Factors and Decreasing Inflammatory Factors in a Mice Model of Alzheimer’s Disease

(2019) Yanfei Ding et al.   JOURNAL OF ALZHEIMERS DISEASE

A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer’s Disease

(2018) Xiong Wang et al.   BIOLOGICAL PSYCHIATRY

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

(2018) Huang Chunhui et al.   Jove-Journal of Visualized Experiments

Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex

(2018) Miki Igarashi et al.   JOURNAL OF ALZHEIMERS DISEASE

Rosiglitazone Prevents Amyloid-β Oligomer-Induced Impairment of Synapse Formation and Plasticity via Increasing Dendrite and Spine Mitochondrial Number

(2018) Shujun Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

PGE 2 -EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease

(2017) Vincent Maingret et al.   NEUROBIOLOGY OF AGING

Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease

(2017) Emanuela Gardenal et al.   Frontiers in Neuroscience

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

(2017) Anna Chiarini et al.   Frontiers in Neuroscience

Molecular pharmacology of G protein-coupled receptors

(2016) R J Summers   BRITISH JOURNAL OF PHARMACOLOGY

Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

(2016) Leide dos Santos Picanç et al.   CURRENT MEDICINAL CHEMISTRY

Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2016) Yura Choi et al.   MOLECULAR NEUROBIOLOGY

Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin

(2016) Teng Wang et al.   NEUROPHARMACOLOGY

Peripherally administered sera antibodies recognizing amyloid-β oligomers mitigate Alzheimer's disease-like pathology and cognitive decline in aged 3× Tg-AD mice

(2016) Hai-Chao Wang et al.   VACCINE

Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway

(2015) Liting Jiang et al.   MOLECULAR NEUROBIOLOGY

Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach

(2015) Andrew F. Teich et al.   Neurotherapeutics

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias

(2015) Katie Leach et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synaptic abnormalities in a Drosophila model of Alzheimer's disease

(2014) S. D. Mhatre et al.   Disease Models & Mechanisms

Role of Cytosolic Phospholipase A2 in Oxidative and Inflammatory Signaling Pathways in Different Cell Types in the Central Nervous System

(2014) Grace Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

(2014) Katherine A Price et al.   Molecular Neurodegeneration

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

(2014) Ilaria Dal Prà et al.   NEUROMOLECULAR MEDICINE

Phospholipase A2 – nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment

(2014) Petra M. Hermann et al.   Frontiers in Genetics

Roles of the calcium sensing receptor in the central nervous system

(2013) Martial Ruat et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Calcium-sensing receptor (CaSR): Pharmacological properties and signaling pathways

(2013) Arthur D. Conigrave et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

(2013) Ubaldo Armato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Calcium-Sensing Receptor as a Regulator of Cellular Fate in Normal and Pathological Conditions

(2013) A. Diez-Fraile et al.   CURRENT MOLECULAR MEDICINE

Janus Kinase 3 Activity Is Necessary for Phosphorylation of Cytosolic Phospholipase A2 and Prostaglandin E2 Synthesis by Macrophages Infected with Francisella tularensis Live Vaccine Strain

(2013) Ashley M. Brummett et al.   INFECTION AND IMMUNITY

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease

(2012) A. O. Ardiles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer’s disease

(2011) Tao Ma et al.   JOURNAL OF NEUROCHEMISTRY

Critical role of cPLA2 in Aβ oligomer-induced neurodegeneration and memory deficit

(2011) Cédric Desbène et al.   NEUROBIOLOGY OF AGING

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Prostaglandin E2-Induced Synaptic Plasticity in Neocortical Networks of Organotypic Slice Cultures

(2010) H. Koch et al.   JOURNAL OF NEUROSCIENCE

Diverse roles of extracellular calcium-sensing receptor in the central nervous system

(2010) Sanghamitra Bandyopadhyay et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Phospholipase A2 inhibitors protect against prion and Aβ mediated synapse degeneration

(2010) Clive Bate et al.   Molecular Neurodegeneration

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Presynaptic External Calcium Signaling Involves the Calcium-Sensing Receptor in Neocortical Nerve Terminals

(2010) Wenyan Chen et al.   PLoS One