Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice

Placebo and Nocebo Effects

(2020) Luana Colloca et al.   NEW ENGLAND JOURNAL OF MEDICINE

A deeper look at pain variability and its relationship with the placebo response

(2019) Roi Treister et al.   PAIN

Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment

(2019) Irene Tracey et al.   NEURON

New concepts of pain

(2019) Anne-Priscille Trouvin et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Neurotransmitter systems involved in placebo and nocebo effects in healthy participants and patients with chronic pain

(2019) Ina Skyt et al.   PAIN

Effects of open-label placebo on pain, functional disability and spine mobility in chronic back pain patients

(2019) Julian Kleine-Borgmann et al.   PAIN

“It’s All in Your Head”—Medicine’s Silent Epidemic

(2019) Matthew J. Burke   JAMA Neurology

Disambiguating pharmacological mechanisms from placebo in neuropathic pain using functional neuroimaging

(2018) V. Wanigasekera et al.   BRITISH JOURNAL OF ANAESTHESIA

Factors Associated With Response to Placebo in Patients With Irritable Bowel Syndrome and Constipation

(2018) Sarah Ballou et al.   Clinical Gastroenterology and Hepatology

Accurate pain reporting training diminishes the placebo response: Results from a randomised, double-blind, crossover trial

(2018) Roi Treister et al.   PLoS One

Learned immunosuppressive placebo responses in renal transplant patients

(2018) Julia Kirchhof et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

(2018) Lorriane Eley et al.   eLife

Symptom perception, placebo effects, and the Bayesian brain

(2018) Giulio Ongaro et al.   PAIN

Brain and psychological determinants of placebo pill response in chronic pain patients

(2018) Etienne Vachon-Presseau et al.   Nature Communications

Placebo Effects on the Neurologic Pain Signature

(2018) Matthias Zunhammer et al.   JAMA Neurology

Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits?

(2018) Ted J Kaptchuk et al.   BMJ-British Medical Journal

Suppression of Striatal Prediction Errors by the Prefrontal Cortex in Placebo Hypoalgesia

(2017) Lieven A. Schenk et al.   JOURNAL OF NEUROSCIENCE

The Placebo Response in Pediatric Abdominal Pain-Related Functional Gastrointestinal Disorders: A Systematic Review and Meta-Analysis

(2017) Daniël R. Hoekman et al.   JOURNAL OF PEDIATRICS

Symptoms and the body: Taking the inferential leap

(2017) Omer Van den Bergh et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Classical conditioning without verbal suggestions elicits placebo analgesia and nocebo hyperalgesia

(2017) Przemysław Bąbel et al.   PLoS One

Bayesian prediction of placebo analgesia in an instrumental learning model

(2017) Won-Mo Jung et al.   PLoS One

Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial

(2017) Sarah Ballou et al.   Trials

Informed consent and clinical trials: where is the placebo effect?

(2017) C R Blease et al.   BMJ-British Medical Journal

Informed consent and clinical trials: where is the placebo effect?

(2017) C R Blease et al.   BMJ-British Medical Journal

Examination of overall treatment effect and the proportion attributable to contextual effect in osteoarthritis: meta-analysis of randomised controlled trials

(2016) Kun Zou et al.   ANNALS OF THE RHEUMATIC DISEASES

Are open-Label Placebos Ethical? Informed Consent and Ethical Equivocations

(2016) Charlotte Blease et al.   BIOETHICS

Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification

(2016) William Maixner et al.   JOURNAL OF PAIN

Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee

(2016) S. Reiter-Niesert et al.   OSTEOARTHRITIS AND CARTILAGE

Meta-analysis of placebo responses in central neuropathic pain

(2016) Jacquelyn J. Cragg et al.   PAIN

Relieving pain using dose-extending placebos

(2016) Luana Colloca et al.   PAIN

Open-label placebo treatment in chronic low back pain

(2016) Cláudia Carvalho et al.   PAIN

Active interoceptive inference and the emotional brain

(2016) Anil K. Seth et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Deconstructing the sensation of pain: The influence of cognitive processes on pain perception

(2016) K. Wiech   SCIENCE

Effectiveness and Implications of Alternative Placebo Treatments

(2015) Raveendhara R. Bannuru et al.   ANNALS OF INTERNAL MEDICINE

An Investigation of Factors Contributing to Higher Levels of Placebo Response in Clinical Trials in Neuropathic Pain: A Systematic Review and Meta-Analysis

(2015) Akio Arakawa et al.   CLINICAL DRUG INVESTIGATION

Measuring expectations of benefit from treatment in acupuncture trials: A systematic review

(2015) Stephanie L. Prady et al.   COMPLEMENTARY THERAPIES IN MEDICINE

The neuroscience of placebo effects: connecting context, learning and health

(2015) Tor D. Wager et al.   NATURE REVIEWS NEUROSCIENCE

Interoceptive predictions in the brain

(2015) Lisa Feldman Barrett et al.   NATURE REVIEWS NEUROSCIENCE

Placebo Effects in Medicine

(2015) Ted J. Kaptchuk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predictors of the placebo analgesia response in randomized controlled trials of chronic pain

(2015) Lene Vase et al.   PAIN

Classical conditioning of analgesic and hyperalgesic pain responses without conscious awareness

(2015) Karin Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational rationality: A converging paradigm for intelligence in brains, minds, and machines

(2015) S. J. Gershman et al.   SCIENCE

Durability of treatment response to zolpidem with three different maintenance regimens: a preliminary study

(2015) Michael Perlis et al.   SLEEP MEDICINE

Not seeing or feeling is still believing: conscious and non-conscious pain modulation after direct and observational learning

(2015) Natalia Egorova et al.   Scientific Reports

A Bayesian Perspective on Sensory and Cognitive Integration in Pain Perception and Placebo Analgesia

(2015) Davide Anchisi et al.   PLoS One

A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses

(2014) Karin B. Jensen et al.   CEREBRAL CORTEX

Representation of aversive prediction errors in the human periaqueductal gray

(2014) Mathieu Roy et al.   NATURE NEUROSCIENCE

Placebo Analgesia: A Predictive Coding Perspective

(2014) Christian Büchel et al.   NEURON

Effect of variability in the 7-day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: An ACTTION study

(2014) John T. Farrar et al.   PAIN

The Use of Placebo and Non-Specific Therapies and Their Relation to Basic Professional Attitudes and the Use of Complementary Therapies among German Physicians – A Cross-Sectional Survey

(2014) Klaus Linde et al.   PLoS One

When and Why Placebo-Prescribing Is Acceptable and Unacceptable: A Focus Group Study of Patients' Views

(2014) Felicity L. Bishop et al.   PLoS One

Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks

(2014) S. Kam-Hansen et al.   Science Translational Medicine

Use of placebo controls in the evaluation of surgery: systematic review

(2014) K. Wartolowska et al.   BMJ-British Medical Journal

Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits

(2013) Javeria A. Hashmi et al.   BRAIN

Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume

(2013) Rachel F. Smallwood et al.   JOURNAL OF PAIN

An fMRI-Based Neurologic Signature of Physical Pain

(2013) Tor D. Wager et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo effect in burning mouth syndrome: a systematic review

(2013) M Kuten-Shorrer et al.   ORAL DISEASES

Brain white matter structural properties predict transition to chronic pain

(2013) Ali R. Mansour et al.   PAIN

Enhanced Therapeutic Alliance Modulates Pain Intensity and Muscle Pain Sensitivity in Patients With Chronic Low Back Pain: An Experimental Controlled Study

(2013) J. Fuentes et al.   PHYSICAL THERAPY

Placebo Use in the United Kingdom: Results from a National Survey of Primary Care Practitioners

(2013) Jeremy Howick et al.   PLoS One

Patients' attitudes about the use of placebo treatments: telephone survey

(2013) S. C. Hull et al.   BMJ-British Medical Journal

Differential Effectiveness of Placebo Treatments

(2013) Karin Meissner et al.   JAMA Internal Medicine

Migraine Therapeutics in Adolescents

(2013) Haihao Sun et al.   JAMA Pediatrics

A Bayesian account of 'hysteria'

(2012) M. J. Edwards et al.   BRAIN

How can a Bayesian approach inform neuroscience?

(2012) Jill X. O’Reilly et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Systematic review: Do patient expectations influence treatment outcomes in total knee and total hip arthroplasty?

(2012) Tsjitske M Haanstra et al.   Health and Quality of Life Outcomes

Corticostriatal functional connectivity predicts transition to chronic back pain

(2012) Marwan N Baliki et al.   NATURE NEUROSCIENCE

Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-Analysis

(2012) M. Soledad Cepeda et al.   PAIN MEDICINE

Exploring communication pathways to better health: Clinician communication of expectations for acupuncture effectiveness

(2012) Richard L. Street et al.   PATIENT EDUCATION AND COUNSELING

Nonconscious activation of placebo and nocebo pain responses

(2012) K. B. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Utilizing placebo mechanisms for dose reduction in pharmacotherapy

(2012) Bettina K. Doering et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dopamine, Affordance and Active Inference

(2012) Karl J. Friston et al.   PLoS Computational Biology

Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma

(2011) Michael E. Wechsler et al.   NEW ENGLAND JOURNAL OF MEDICINE

You may (not always) experience what you expect: In search for the limits of the placebo and nocebo effect

(2011) Geert Crombez et al.   PAIN

Systematic review: Placebo response in drug trials of fibromyalgia syndrome and painful peripheral diabetic neuropathy—magnitude and patient-related predictors

(2011) Winfried Häuser et al.   PAIN

Practice, practitioner, or placebo? A multifactorial, mixed-methods randomized controlled trial of acupuncture

(2011) Peter White et al.   PAIN

Concordance between physician communication style and patient attitudes predicts patient satisfaction

(2011) Gaëtan Cousin et al.   PATIENT EDUCATION AND COUNSELING

Placebo studies and ritual theory: a comparative analysis of Navajo, acupuncture and biomedical healing

(2011) T. J. Kaptchuk   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

How to Grow a Mind: Statistics, Structure, and Abstraction

(2011) J. B. Tenenbaum et al.   SCIENCE

Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome

(2010) A. C. Ford et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Frequency and circumstances of placebo use in clinical practice - a systematic review of empirical studies

(2010) Margrit Fässler et al.   BMC Medicine

Conditioned Placebo Dose Reduction: A New Treatment in Attention-Deficit Hyperactivity Disorder?

(2010) Adrian D. Sandler et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Expectation and Surprise Determine Neural Population Responses in the Ventral Visual Stream

(2010) T. Egner et al.   JOURNAL OF NEUROSCIENCE

Biological, clinical, and ethical advances of placebo effects

(2010) Damien G Finniss et al.   LANCET

Inclusion of authorized deception in the informed consent process does not affect the magnitude of the placebo effect for experimentally induced pain

(2010) Andrea L. Martin et al.   PAIN

Predictive Coding or Evidence Accumulation? False Inference and Neuronal Fluctuations

(2010) Guido Hesselmann et al.   PLoS One

Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome

(2010) Ted J. Kaptchuk et al.   PLoS One

Treatment Expectations and Preferences as Predictors of Outcome of Acupuncture for Chronic Back Pain

(2010) Karen J. Sherman et al.   SPINE

A randomized controlled trial of acupuncture for osteoarthritis of the knee: Effects of patient-provider communication

(2010) Maria E. Suarez-Almazor et al.   ARTHRITIS CARE & RESEARCH

Predictors of Placebo Response in Pooled Lamotrigine Neuropathic Pain Clinical Trials

(2009) Michael C. Irizarry et al.   CLINICAL JOURNAL OF PAIN

The relationship between patient and practitioner expectations and preferences and clinical outcomes in a trial of exercise and acupuncture for knee osteoarthritis

(2009) Nadine E. Foster et al.   EUROPEAN JOURNAL OF PAIN

Randomized trial of the effect of drug presentation on asthma outcomes: The American Lung Association Asthma Clinical Research Centers

(2009) Robert A. Wise et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Physician Communication and Patient Adherence to Treatment

(2009) Kelly B. Haskard Zolnierek et al.   MEDICAL CARE

Conditioned Pharmacotherapeutic Effects: A Preliminary Study

(2009) Robert Ader et al.   PSYCHOSOMATIC MEDICINE

The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials

(2008) W Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Deception of Subjects in Neuroscience: An Ethical Analysis

(2008) F. G. Miller et al.   JOURNAL OF NEUROSCIENCE

Common Chronic Pain Conditions in Developed and Developing Countries: Gender and Age Differences and Comorbidity With Depression-Anxiety Disorders

(2008) Adley Tsang et al.   JOURNAL OF PAIN

Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome

(2008) Ted J Kaptchuk et al.   BMJ-British Medical Journal

Hierarchical Models in the Brain

(2008) Karl Friston   PLoS Computational Biology

Placebo response in the prophylaxis of migraine: A meta-analysis

(2007) Ana Macedo et al.   EUROPEAN JOURNAL OF PAIN