The neuroscience of placebo effects: connecting context, learning and health

Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain

(2015) Choong-Wan Woo et al.   PLOS BIOLOGY

Role of pill-taking, expectation and therapeutic alliance in the placebo response in clinical trials for major depression

(2014) Andrew F. Leuchter et al.   BRITISH JOURNAL OF PSYCHIATRY

Intracortical modulation, and not spinal inhibition, mediates placebo analgesia

(2014) M. Martini et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of explicit verbal information in conditioned analgesia

(2014) E. Carlino et al.   EUROPEAN JOURNAL OF PAIN

Reward and motivation in pain and pain relief

(2014) Edita Navratilova et al.   NATURE NEUROSCIENCE

Mind matters: placebo enhances reward learning in Parkinson's disease

(2014) Liane Schmidt et al.   NATURE NEUROSCIENCE

Expectation in perceptual decision making: neural and computational mechanisms

(2014) Christopher Summerfield et al.   NATURE REVIEWS NEUROSCIENCE

Pain and the context

(2014) Elisa Carlino et al.   Nature Reviews Rheumatology

Placebo Effects: From the Neurobiological Paradigm to Translational Implications

(2014) Fabrizio Benedetti   NEURON

Placebo Analgesia: A Predictive Coding Perspective

(2014) Christian Büchel et al.   NEURON

Placebo treatment can alter primary visual cortex activity and connectivity

(2014) A. Schienle et al.   NEUROSCIENCE

Nocebo and placebo modulation of hypobaric hypoxia headache involves the cyclooxygenase-prostaglandins pathway

(2014) Fabrizio Benedetti et al.   PAIN

Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

(2014) N. Schwartz et al.   SCIENCE

Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks

(2014) S. Kam-Hansen et al.   Science Translational Medicine

Separate neural representations for physical pain and social rejection

(2014) Choong-Wan Woo et al.   Nature Communications

Placebo-induced immunosuppression in humans: Role of learning and expectation

(2013) Laura Wendt et al.   BRAIN BEHAVIOR AND IMMUNITY

Effect of Oxytocin on Placebo Analgesia

(2013) Simon Kessner et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prior Expectations Bias Sensory Representations in Visual Cortex

(2013) P. Kok et al.   JOURNAL OF NEUROSCIENCE

Facilitation of Pain in the Human Spinal Cord by Nocebo Treatment

(2013) S. Geuter et al.   JOURNAL OF NEUROSCIENCE

The contextual brain: implications for fear conditioning, extinction and psychopathology

(2013) Stephen Maren et al.   NATURE REVIEWS NEUROSCIENCE

How initial confirmatory experience potentiates the detrimental influence of bad advice

(2013) Markus R. Staudinger et al.   NEUROIMAGE

An fMRI-Based Neurologic Signature of Physical Pain

(2013) Tor D. Wager et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expectation requires treatment to boost pain relief: An fMRI study

(2013) Lieven A. Schenk et al.   PAIN

Placebo improves pleasure and pain through opposite modulation of sensory processing

(2013) D.-M. Ellingsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advertisements impact the physiological efficacy of a branded drug

(2013) E. Kamenica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of discrete functional subregions of the human periaqueductal gray

(2013) A. B. Satpute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specifying the non-specific factors underlying opioid analgesia: expectancy, attention, and affect

(2013) Lauren Y. Atlas et al.   PSYCHOPHARMACOLOGY

Disgust regulation via placebo: an fMRI study

(2013) Anne Schienle et al.   Social Cognitive and Affective Neuroscience

The Neuroscience of Learning: Beyond the Hebbian Synapse

(2012) C.R. Gallistel et al.   Annual Review of Psychology

The brain basis of emotion: A meta-analytic review

(2012) Kristen A. Lindquist et al.   BEHAVIORAL AND BRAIN SCIENCES

Adherence to placebo and mortality in the Beta Blocker Evaluation of Survival Trial (BEST)

(2012) Alice Pressman et al.   Contemporary Clinical Trials

Dissociable Influences of Opiates and Expectations on Pain

(2012) L. Y. Atlas et al.   JOURNAL OF NEUROSCIENCE

Individual Differences in Nucleus Accumbens Activity to Food and Sexual Images Predict Weight Gain and Sexual Behavior

(2012) K. E. Demos et al.   JOURNAL OF NEUROSCIENCE

Corticostriatal functional connectivity predicts transition to chronic back pain

(2012) Marwan N Baliki et al.   NATURE NEUROSCIENCE

Cortical and subcortical responses to high and low effective placebo treatments

(2012) Stephan Geuter et al.   NEUROIMAGE

Personality Trait Predictors of Placebo Analgesia and Neurobiological Correlates

(2012) Marta Peciña et al.   NEUROPSYCHOPHARMACOLOGY

Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients

(2012) Hsing-Feng Lee et al.   PAIN

White matter integrity of the descending pain modulatory system is associated with interindividual differences in placebo analgesia

(2012) Niklas Stein et al.   PAIN

Functional connectivity of the frontoparietal network predicts cognitive modulation of pain

(2012) Jian Kong et al.   PAIN

Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects

(2012) V. Wanigasekera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural mechanism of placebo effects and cognitive reappraisal in emotion regulation

(2012) Wencai Zhang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Common representation of pain and negative emotion in the midbrain periaqueductal gray

(2012) Jason T. Buhle et al.   Social Cognitive and Affective Neuroscience

Ventromedial prefrontal-subcortical systems and the generation of affective meaning

(2012) Mathieu Roy et al.   TRENDS IN COGNITIVE SCIENCES

Plasma Noradrenaline and State Anxiety Levels Predict Placebo Response in Learned Immunosuppression

(2011) K Ober et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Neural activity during health messaging predicts reductions in smoking above and beyond self-report.

(2011) Emily B. Falk et al.   HEALTH PSYCHOLOGY

Mind over milkshakes: Mindsets, not just nutrients, determine ghrelin response.

(2011) Alia J. Crum et al.   HEALTH PSYCHOLOGY

Predicting Individual Differences in Placebo Analgesia: Contributions of Brain Activity during Anticipation and Pain Experience

(2011) T. D. Wager et al.   JOURNAL OF NEUROSCIENCE

Prior Expectation Modulates the Interaction between Sensory and Prefrontal Regions in the Human Brain

(2011) D. Rahnev et al.   JOURNAL OF NEUROSCIENCE

Focusing Attention on the Health Aspects of Foods Changes Value Signals in vmPFC and Improves Dietary Choice

(2011) T. A. Hare et al.   JOURNAL OF NEUROSCIENCE

Large-scale automated synthesis of human functional neuroimaging data

(2011) Tal Yarkoni et al.   NATURE METHODS

Neuroimaging of the periaqueductal gray: State of the field

(2011) Clas Linnman et al.   NEUROIMAGE

Toward affective circuit-based preclinical models of depression: Sensitizing dorsal PAG arousal leads to sustained suppression of positive affect in rats

(2011) Jason S. Wright et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma

(2011) Michael E. Wechsler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Investigating dose-dependent effects of placebo analgesia: A psychophysiological approach

(2011) Yoshio Nakamura et al.   PAIN

Neural mechanisms mediating the effects of expectation in visceral placebo analgesia: An fMRI study in healthy placebo responders and nonresponders

(2011) Sigrid Elsenbruch et al.   PAIN

Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides

(2011) Jun Yang et al.   PEPTIDES

The relation of emotions to placebo responses

(2011) M. A. Flaten et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The placebo effect and the autonomic nervous system: evidence for an intimate relationship

(2011) K. Meissner   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Social rejection shares somatosensory representations with physical pain

(2011) E. Kross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Placebo analgesia affects the behavioral despair tests and hormonal secretions in mice

(2011) Jian-You Guo et al.   PSYCHOPHARMACOLOGY

A follow-up fMRI study of a transferable placebo anxiolytic effect

(2011) Wencai Zhang et al.   PSYCHOPHYSIOLOGY

Gender Differences in Placebo Analgesia: Event-Related Potentials and Emotional Modulation

(2011) Per M. Aslaksen et al.   PSYCHOSOMATIC MEDICINE

Following the Crowd: Brain Substrates of Long-Term Memory Conformity

(2011) M. Edelson et al.   SCIENCE

Promoting the Middle East Peace Process by Changing Beliefs About Group Malleability

(2011) E. Halperin et al.   SCIENCE

The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil

(2011) U. Bingel et al.   Science Translational Medicine

The Neural Basis of Following Advice

(2011) Guido Biele et al.   PLOS BIOLOGY

Effects of Expectation on Placebo-Induced Dopamine Release in Parkinson Disease

(2010) Sarah C. Lidstone et al.   ARCHIVES OF GENERAL PSYCHIATRY

Placebo Adherence and Its Association with Morbidity and Mortality in the Studies of Left Ventricular Dysfunction

(2010) Andrew L. Avins et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Nociceptive Processing by Anterior Cingulate Pyramidal Neurons

(2010) Bai-Chuang Shyu et al.   JOURNAL OF NEUROPHYSIOLOGY

Brain Mediators of Predictive Cue Effects on Perceived Pain

(2010) L. Y. Atlas et al.   JOURNAL OF NEUROSCIENCE

Anterior Insula Integrates Information about Salience into Perceptual Decisions about Pain

(2010) K. Wiech et al.   JOURNAL OF NEUROSCIENCE

Varying Perceived Social Threat Modulates Pain Behavior in Male Mice

(2010) Dale J. Langford et al.   JOURNAL OF PAIN

Cognitive changes as a result of a single exposure to placebo

(2010) Debbie L. Morton et al.   NEUROPSYCHOLOGIA

How Placebos Change the Patient's Brain

(2010) Fabrizio Benedetti et al.   NEUROPSYCHOPHARMACOLOGY

A prefrontal non-opioid mechanism in placebo analgesia

(2010) Predrag Petrovic et al.   PAIN

Neural bases of conditioned placebo analgesia

(2010) Fausta Lui et al.   PAIN

Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome

(2010) Ted J. Kaptchuk et al.   PLoS One

How instructed knowledge modulates the neural systems of reward learning

(2010) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal-striatal pathway underlies cognitive regulation of craving

(2010) H. Kober et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical activation of lateral amygdala pyramidal cells instructs associative fear learning

(2010) Joshua P. Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The learned immune response: Pavlov and beyond

(2009) Manfred Schedlowski et al.   BRAIN BEHAVIOR AND IMMUNITY

Instructional control of reinforcement learning: A behavioral and neurocomputational investigation

(2009) Bradley B. Doll et al.   BRAIN RESEARCH

Evidence for a Common Representation of Decision Values for Dissimilar Goods in Human Ventromedial Prefrontal Cortex

(2009) V. S. Chib et al.   JOURNAL OF NEUROSCIENCE

The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response

(2009) P. Schweinhardt et al.   JOURNAL OF NEUROSCIENCE

Brain mediators of cardiovascular responses to social threat, Part II: Prefrontal-subcortical pathways and relationship with anxiety

(2009) Tor D. Wager et al.   NEUROIMAGE

Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia

(2009) Falk Eippert et al.   NEURON

Pain relief through expectation supersedes descending inhibitory deficits in fibromyalgia patients

(2009) Philippe Goffaux et al.   PAIN

Reproducibility of placebo analgesia: Effect of dispositional optimism

(2009) Debbie L. Morton et al.   PAIN

Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception

(2009) Alison Watson et al.   PAIN

Factors contributing to large analgesic effects in placebo mechanism studies conducted between 2002 and 2007

(2009) Lene Vase et al.   PAIN

Neuronal correlates in the modulation of placebo analgesia in experimentally-induced esophageal pain: A 3T-fMRI study

(2009) Hsueh-Chieh Lu et al.   PAIN

Prefrontal cortex modulates placebo analgesia

(2009) Peter Krummenacher et al.   PAIN

Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

(2009) A. E. Metz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced analgesia

(2009) Ryan K. Butler et al.   PROGRESS IN NEUROBIOLOGY

The transferable placebo effect from pain to emotion: Changes in behavior and EEG activity

(2009) Wencai Zhang et al.   PSYCHOPHYSIOLOGY

Direct Evidence for Spinal Cord Involvement in Placebo Analgesia

(2009) F. Eippert et al.   SCIENCE

Self-Control in Decision-Making Involves Modulation of the vmPFC Valuation System

(2009) T. A. Hare et al.   SCIENCE

The Placebo Effect in Sports Performance

(2009) Christopher J. Beedie et al.   SPORTS MEDICINE

Expectation (and attention) in visual cognition

(2009) Christopher Summerfield et al.   TRENDS IN COGNITIVE SCIENCES

Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses

(2008) David J. Scott et al.   ARCHIVES OF GENERAL PSYCHIATRY

Believing is seeing: expectations alter visual awareness

(2008) Philipp Sterzer et al.   CURRENT BIOLOGY

Placebo response in Parkinson's disease: Comparisons among 11 trials covering medical and surgical interventions

(2008) Christopher G. Goetz et al.   MOVEMENT DISORDERS

What we can do and what we cannot do with fMRI

(2008) Nikos K. Logothetis   NATURE

Expectancy and treatment interactions: A dissociation between acupuncture analgesia and expectancy evoked placebo analgesia

(2008) Jian Kong et al.   NEUROIMAGE

New Insights into the Placebo and Nocebo Responses

(2008) Paul Enck et al.   NEURON

Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation

(2008) Tor D. Wager et al.   NEURON

The dynamic mechanisms of placebo induced analgesia: Evidence of sustained and transient regional involvement

(2008) Jason G. Craggs et al.   PAIN

Learning potentiates neurophysiological and behavioral placebo analgesic responses

(2008) Luana Colloca et al.   PAIN

Marketing actions can modulate neural representations of experienced pleasantness

(2008) H. Plassmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome

(2008) Ted J Kaptchuk et al.   BMJ-British Medical Journal

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

(2008) Irving Kirsch et al.   PLOS MEDICINE