Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

(2019) Natalia N. Nalivaeva et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect

(2018) Yasir H. Qureshi et al.   MOLECULAR AND CELLULAR BIOLOGY

Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice

(2017) Shaowu Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10

(2016) Anett Ketscher et al.   BIOCHIMIE

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

Pleiotropic Effects of Cathepsin D

(2012) Aruna Vashishta et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Dynamic Analysis of Amyloid  -Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal A  during Age-Related Plaque Formation

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

(2010) Zeshan Ahmed et al.   AMERICAN JOURNAL OF PATHOLOGY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

(2010) Rodrigo A. Fuentealba et al.   PLoS One

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

(2010) Vikram Khurana et al.   PLoS Genetics

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE