Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines

High-Throughput Gene Expression Profiles to Define Drug Similarity and Predict Compound Activity

(2018) Hans De Wolf et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Determining mechanisms of mitochondrial toxicity using Agilent Seahorse XF Technology

(2018) N. Romero et al.   TOXICOLOGY LETTERS

DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

(2018) Chaoyang Ye et al.   Nature Communications

The Drug Repurposing Hub: a next-generation drug library and information resource

(2017) Steven M Corsello et al.   NATURE MEDICINE

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin

(2017) Karin Brecht et al.   TOXICOLOGY IN VITRO

Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets

(2017) Bin Chen et al.   Nature Communications

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

The ChEMBL database in 2017

(2016) Anna Gaulton et al.   NUCLEIC ACIDS RESEARCH

In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma

(2016) Ziyan Y. Pessetto et al.   Oncotarget

Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) Ivan Kopljar et al.   Stem Cells Translational Medicine

Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints

(2015) Felix Reisen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines

(2015) Jungseog Kang et al.   NATURE BIOTECHNOLOGY

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

(2014) M. J. Wawer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

(2013) Robert H. Oakley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

(2013) Sigrun M. Gustafsdottir et al.   PLoS One

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

(2012) Yushi Futamura et al.   CHEMISTRY & BIOLOGY

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE