Cigarette smoke induces endoplasmic reticulum stress and suppresses efferocytosis through the activation of RhoA

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

(2019) Mohamed Mahameed et al.   Cell Death & Disease

Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives

(2019) Magdalena Kusaczuk   Cells

AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis

(2018) R. Stöhr et al.   Scientific Reports

Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite

(2017) Sang-Yeob Kim et al.   PLoS One

Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load

(2016) L. K. Walsh et al.   CLINICAL SCIENCE

Natural Compounds from Saffron and Bear Bile Prevent Vision Loss and Retinal Degeneration

(2015) Laura Fernández-Sánchez et al.   MOLECULES

Z α1-Antitrypsin Confers a Proinflammatory Phenotype That Contributes to Chronic Obstructive Pulmonary Disease

(2014) Samuel Alam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway

(2014) Dan Hong et al.   ATHEROSCLEROSIS

Role of alveolar macrophages in chronic obstructive pulmonary disease

(2014) Ross Vlahos   Frontiers in Immunology

Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages

(2013) P. Costales et al.   ATHEROSCLEROSIS

Efferocytosis and Lung Disease

(2013) Alexandra L. McCubbrey et al.   CHEST

Cigarette smoke impairs phagocytosis of apoptotic neutrophils by alveolar macrophages via inhibition of the histone deacetylase/Rac/CD9 pathways

(2013) Naotaka Noda et al.   INTERNATIONAL IMMUNOLOGY

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

(2013) J.M. Gaspar et al.   NEUROSCIENCE

12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response

(2012) Banumathi K. Cole et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis

(2012) Harikrishna Tanjore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells

(2012) Anita Somborac-Bačura et al.   EXPERIMENTAL PHYSIOLOGY

Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase

(2012) Harshavardhan Kenche et al.   FASEB JOURNAL

Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

(2012) James G. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Defective efferocytosis by alveolar macrophages in IPF patients

(2012) Konosuke Morimoto et al.   RESPIRATORY MEDICINE

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

(2011) William J Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Decreased efferocytosis and mannose binding lectin in the airway in bronchiolitis obliterans syndrome

(2011) Sandra Hodge et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

(2011) W. E. Lawson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette Smoke-Induced Changes to Alveolar Macrophage Phenotype and Function Are Improved by Treatment with Procysteine

(2010) Sandra Hodge et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation

(2010) Takeshi Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

RhoA-mediated signaling up-regulates hepatocyte growth factor gene and protein expression in response to apoptotic cells

(2010) Hyun-Jung Park et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endoplasmic reticulum stress and atherosclerosis

(2010) Gökhan S Hotamisligil   NATURE MEDICINE

Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2009) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoke Impairs Clearance of Apoptotic Cells through Oxidant-dependent Activation of RhoA

(2009) Tiffany R. Richens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester

(2009) Michael Miksa et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis

(2008) Martina Korfei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Copper Binding Domain of SPARC Mediates Cell Survivalin Vitrovia Interaction with Integrin β1 and Activation of Integrin-linked Kinase

(2008) Matt S. Weaver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY