Structure-based designing efficient peptides based on p53 binding site residues to disrupt p53-MDM2/X interaction
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure-based designing efficient peptides based on p53 binding site residues to disrupt p53-MDM2/X interaction
Authors
Keywords
-
Journal
Scientific Reports
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-07-10
DOI
10.1038/s41598-020-67510-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Insight Into the Binding Mechanism of p53/pDIQ-MDMX/MDM2 With the Interaction Entropy Method
- (2019) Mengxin Li et al. Frontiers in Chemistry
- In Vitro Characterization of a Potent p53-MDM2 Inhibitor, RG7112 in Neuroblastoma Cancer Cell Lines
- (2019) Abdulhameed Al-Ghabkari et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides
- (2019) David J. Diller et al. MOLECULES
- Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions
- (2018) Naomi Robertson et al. MOLECULES
- gRINN: a tool for calculation of residue interaction energies and protein energy network analysis of molecular dynamics simulations
- (2018) Onur Serçinoğlu et al. NUCLEIC ACIDS RESEARCH
- Stapled peptides as a new technology to investigate protein–protein interactions in human platelets
- (2018) Jessica Iegre et al. Chemical Science
- Molecular Simulations Identify Binding Poses and Approximate Affinities of Stapled α-Helical Peptides to MDM2 and MDMX
- (2017) Joseph A. Morrone et al. Journal of Chemical Theory and Computation
- High Expression of Human Homologue of Murine Double Minute 4 and the Short Splicing Variant, HDM4-S, in Bone Marrow in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
- (2016) Xin Han et al. Clinical Lymphoma Myeloma & Leukemia
- Recognition Dynamics of p53 and MDM2: Implications for Peptide Design
- (2016) Karim M. ElSawy et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Clinical pharmacology characterization of RG7112, an MDM2 antagonist, in patients with advanced solid tumors
- (2015) Amita Patnaik et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas
- (2015) M. Verreault et al. CLINICAL CANCER RESEARCH
- Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
- (2014) Grzegorz Popowicz et al. CELL CYCLE
- Molecular dynamics simulations studies and free energy analysis on inhibitors of MDM2–p53 interaction
- (2013) Rui-Juan Niu et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
- (2013) Yong S. Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p53 mutations in cancer
- (2012) Patricia A. J. Muller et al. NATURE CELL BIOLOGY
- MDM4 is a key therapeutic target in cutaneous melanoma
- (2012) Agnieszka Gembarska et al. NATURE MEDICINE
- C-Terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms
- (2011) Christopher J. Brown et al. PLoS One
- Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis
- (2010) M. Ito et al. CLINICAL CANCER RESEARCH
- Assessing the Stability of Alzheimer’s Amyloid Protofibrils Using Molecular Dynamics
- (2010) Justin A. Lemkul et al. JOURNAL OF PHYSICAL CHEMISTRY B
- A series of PDB related databases for everyday needs
- (2010) R. P. Joosten et al. NUCLEIC ACIDS RESEARCH
- Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
- (2009) Jason Phan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?
- (2009) Mark Wade et al. MOLECULAR CANCER RESEARCH
- Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
- (2009) M. Pazgier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiple Peptide Conformations Give Rise to Similar Binding Affinities: Molecular Simulations of p53-MDM2
- (2008) Shubhra Ghosh Dastidar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation
- (2007) Berk Hess Journal of Chemical Theory and Computation
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now