Article
Immunology
Ehsan Gharib, Vanessa Veilleux, Luc H. Boudreau, Nicolas Pichaud, Gilles A. Robichaud
Summary: Inflammation and platelets promote cancer malignancy. Platelet-derived microparticles (PMPs) induce metabolic plasticity and disease progression in chronic lymphocytic leukemia (CLL). PMPs enhance CLL tumor growth and invasiveness through mitochondrial internalization and OXPHOS stimulation, as well as increase resistance to chemotherapy drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Daniel Cacic, Hakon Reikvam, Oddmund Nordgard, Peter Meyer, Tor Hervig
Summary: The study demonstrates that platelet microparticles can alter the behavior and activity of THP-1 cells, contributing to the development of acute myelogenous leukemia and resistance to chemotherapy. This finding highlights the potential role of platelet microparticles as a target for treatment in leukemia cases.
Article
Biochemistry & Molecular Biology
Rosa Suades, Teresa Padro, Gemma Vilahur, Lina Badimon
Summary: Platelets play essential roles in thrombosis, inflammation, and angiogenesis. Stimulation by thrombin triggers the release of pEVs from platelets, which are rich in procoagulant and proadhesive proteins. Differential proteomic analysis revealed significant changes in protein composition between pEVs from activated platelets and non-activated platelets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Chaojun Tang, Lei Wang, Yulan Sheng, Zhong Zheng, Zhanli Xie, Fan Wu, Tao You, Lijie Ren, Lijun Xia, Changgeng Ruan, Li Zhu
Summary: This study demonstrated that disturbed blood flow can induce platelet accumulation in atherosclerosis, with CLEC-2 gene knockout potentially reducing subendothelial accumulation of platelets and monocytes/macrophages, thereby ameliorating plaque formation.
Review
Biochemistry & Molecular Biology
Chiara Gardin, Letizia Ferroni, Sara Leo, Elena Tremoli, Barbara Zavan
Summary: This review summarizes the role of platelet-derived exosomes in intercellular communication in the pathogenesis of atherosclerosis, as well as their potential as biomarkers for AS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daniel Cacic, Oddmund Nordgard, Peter Meyer, Tor Hervig
Summary: In this study, platelet microparticles (PMPs) were found to protect AML cells against apoptosis by transferring bioactive molecules to cancer cells and downregulating the pro-apoptotic PUMA protein, thereby reducing DNA damage induced by chemotherapeutic agents. These findings suggest a potential role for PMPs in modulating apoptosis in AML cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Sean P. Heffron, Ada Weinstock, Bianca Scolaro, Shiyu Chen, Brian E. Sansbury, Greg Marecki, Christina C. Rolling, Hanane El Bannoudi, Tessa Barrett, James W. Canary, Matthew Spite, Jeffrey S. Berger, Edward A. Fisher
Summary: Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. This effect is partially mediated by prostaglandin E2 stimulating the EP4 receptor on macrophages, leading to altered gene expression and function.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Biochemistry & Molecular Biology
Dina A. I. Albadawi, Divyashree Ravishankar, Thomas M. Vallance, Ketan Patel, Helen M. I. Osborn, Sakthivel Vaiyapuri
Summary: Cardiovascular diseases, particularly thrombotic diseases, are a leading cause of mortality worldwide. Unnecessary activation of platelets can lead to thrombus formation, but a healthy diet can help prevent these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Marcel Rodrigues Ferreira, Willian Fernando Zambuzzi
Summary: By analyzing the role of miRNAs in osteogenic differentiation, this study identified potential therapeutic miRNAs and targets in bone healing and tissue engineering through examining miRNAseq expression profiles and constructing an ePPI network.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Rheumatology
Angelo A. Manfredi, Giuseppe A. Ramirez, Cosmo Godino, Annalisa Capobianco, Antonella Monno, Stefano Franchini, Enrico Tombetti, Sara Corradetti, Jorg H. W. Distler, Marco E. Bianchi, Patrizia Rovere-Querini, Norma Maugeri
Summary: In patients with systemic sclerosis (SSc), there is an accumulation of activated P-selectin+ platelets and platelet-derived HMGB1+ microparticles (MPs) in the blood, indicating a potential defect in phagocytosis. Compared to patients with stable coronary artery disease (CAD), SSc patients have decreased expression of PSGL-1 in neutrophils, leading to impaired recognition and clearance of activated platelets, and subsequent release of MPs. This imbalance in platelet clearance may contribute to vascular inflammation and fibrosis in SSc.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Eran Brown, Koya Ozawa, Federico Moccetti, Amanda Vinson, James Hodovan, The Anh Nguyen, Lindsay Bader, Jose A. Lopez, Paul Kievit, Gray D. Shaw, Dominic W. Chung, Warren Osborn, Xiaoyun Fu, Junmei Chen, Jonathan R. Lindner
Summary: In obese and insulin-resistant nonhuman primates, platelet-endothelial adhesion occurs at early atherosclerotic lesion sites, associated with expression of pro-inflammatory adhesion molecules. These responses are partly mediated through oxidative pathways.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Jonathan Mandel, Martina Casari, Maria Stepanyan, Alexey Martyanov, Carsten Deppermann
Summary: There is growing evidence that platelets have functions beyond their traditional roles in thrombosis and hemostasis. They interact and regulate cells of the innate immune system, such as neutrophils, monocytes, and macrophages, and play roles in inflammatory processes, infection, and cancer. This review focuses on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. The contributions of major platelet receptors and secretions from platelet granules on platelet-neutrophil aggregate and neutrophil extracellular trap (NET) formation in various diseases are examined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Brian Schnoor, Anne-Laure Papa
Summary: Lyophilized platelets, as a potential hemostatic agent, have long-term ambient storage capabilities and high biocompatibility, which make them a promising platform for drug delivery. The interactions between lyophilized platelets and fresh platelets have paradoxical effects on platelet adhesion and aggregation, which could have an impact for clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Muataz Ali Hamad, Krystin Krauel, Nancy Schanze, Nadine Gauchel, Peter Stachon, Thomas Nuehrenberg, Mark Zurek, Daniel Duerschmied
Summary: In addition to their role in hemostasis and thrombosis, platelets also play a role in modulating inflammatory reactions and immune responses. Circulating platelets can differ within an individual due to their different physical properties and can be categorized into distinct subtypes based on their function or age. Understanding platelet phenotypic variation is important in various physiological and pathological circumstances.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gaetan Chicanne, Maria N. Barrachina, Anaelle Durbec, Justine Bertrand-Michel, Sara Troitino, Lidia Hermida-Nogueira, Aurelio M. Sueiro, Maria Pardo, Bernard Payrastre, Angel Garcia
Summary: The goal of this study was to compare the lipid profile of platelets from non-diabetic patients with severely obese patients. The results showed that platelets from obese patients had a unique lipid fingerprint, which may be related to the hyperactive state of platelets in obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Ali Khoddami, Valeria Messina, Komala Vadabalija Venkata, Asgar Farahnaky, Christopher L. Blanchard, Thomas H. Roberts
Summary: Sorghum grain is a major staple food in Africa and Asia, but it is primarily used as animal feed in Western countries. However, due to the ability of sorghum crops to resist heat and drought and the excellent functional properties of sorghum in healthy diets, there is potential for the development of new sorghum-based foods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Raiyan Mahbub, Esther Callcott, Shiwangni Rao, Omid Ansari, Daniel L. E. Waters, Christopher L. Blanchard, Abishek B. Santhakumar
Summary: Hemp seed protein hydrolysates (HSPH) alleviated biomarkers of endothelial dysfunction by reducing oxidative stress, inflammation, and platelet activation.
Article
Chemistry, Analytical
Saira Hussain, Ata Ur Rehman, Hassan K. Obied, David J. Luckett, Christopher L. Blanchard
Summary: Canola meal extracts were generated using different solvents, and water was found to be the best solvent for the recovery of glucosinolates. Genotype-2 canola meal had higher quantities of phenolic, glucosinolate, and antioxidant compounds compared to genotype-1. Analysis revealed the presence of 32 compounds, including nine glucosinolates and twenty-three phenolic derivatives, in canola meal extracts. Some of these extracts exhibited mild to moderate in-vitro antidiabetic activity.
Review
Food Science & Technology
Stephen David Cork, Chris Blanchard, Andrew John Mawson, Asgar Farahnaky
Summary: Pulses provide economic and health benefits to people worldwide, but their adoption in western diets is limited. To increase pulse consumption, accessibility to the ready-to-eat food market needs to be improved through systematic studies on pulse processing and the production of high-quality pulse-based foods.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Chemistry, Applied
Mei Li, Jing Wang, Fenfen Wang, Ming Wu, Rui Wang, Padraig Strappe, Chris Blanchard, Zhongkai Zhou
Summary: The effect of acylation with various short-chain fatty acids on starch structure, digestion, and gut microbiota fermentation was studied. Results showed that acylation altered the internal structure of starch and led to the formation of different fractal structures. Additionally, intestinal flora can effectively release acyl groups introduced onto starch molecules during fermentation, increasing the production of specific short-chain fatty acids.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Borkwei Ed Nignpense, Sajid Latif, Nidhish Francis, Christopher Blanchard, Abishek Bommannan Santhakumar
Summary: Polyphenol-rich purple rice has been found to have various health benefits, including antioxidant activity. This study investigated the effect of gastrointestinal digestion on the bioaccessibility and antioxidant activity of purple rice. The results showed a significant difference in bioaccessible phenolic content and antioxidant activity between gastric and intestinal digestion. However, the number of bioaccessible polyphenols decreased after digestion, but significant free radical scavenging activity was still retained due to the bioaccessibility of bioactive compounds such as tryptophan and protocatechuic acid.
Article
Chemistry, Applied
Rui Wang, Jing Wang, Min Liu, Padraig Strappe, Mei Li, Anqi Wang, Min Zhuang, Jinguang Liu, Chris Blanchard, Zhongkai Zhou
Summary: Different types of starch exhibit different acetylation tendencies under the same reaction conditions. Acetylation affects starch crystalline structure and thermodynamic stability, leading to a reduction in surface pore structure. Acetylated starch granules produce more short-chain fatty acids during microbiome fermentation, with A-type starch fermented at a faster rate by gut bacteria microbiota and acylated starch more easily utilized by gut microbiota.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Borkwei Ed Nignpense, Sajid Latif, Nidhish Francis, Christopher Blanchard, Abishek Bommannan Santhakumar
Summary: This study characterised polyphenols from pigmented cereals and evaluated their bioaccessibility and antioxidant activity. The findings showed that these pigmented cereal varieties are sources of bioaccessible polyphenols with antioxidant activity.
Article
Chemistry, Applied
Heidi Bochenek, Nidhish Francis, Abishek B. Santhakumar, Christopher L. Blanchard, Kenneth A. Chinkwo
Summary: This study compared the effects of water leached out from cooking chickpeas and chickpea polyphenol extract on colorectal cancer cells, and found that both have anticancer and antioxidant activities. The findings suggest that the water from cooking chickpeas should not be discarded as it contains beneficial bioactive compounds.
Article
Biochemistry & Molecular Biology
Rui Wang, Mei Li, Min Liu, Anqi Wang, Padraig Strappe, Chris Blanchard, Zhongkai Zhou
Summary: The Pickering emulsion was prepared using esterified debranched starch with short-chain fatty acids (SCFAs). The introduction of acyl groups improved the ability of starch to stabilize the emulsions, with butyrylated starch showing the highest emulsifying ability. The emulsions stabilized with butyrylated starch had better stability and smaller droplet sizes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Siong H. Tan, Christopher L. Blanchard, Thomas H. Roberts, Daniel L. E. Waters, A. John Mawson
Summary: The fermentation performance of 11 commercial sorghum cultivars for ethanol production was investigated. It was found that cultivars with high-starch and low-protein grains were the most suitable for fermentation, resulting in high ethanol content and fermentability.
Article
Cell Biology
Kishor Mazumder, Asma Aktar, Sujatha Ramasamy, Biswajit Biswas, Philip G. Kerr, Christopher Blanchard
Summary: This research investigates the anti-proliferation and apoptosis-inducing effects of nine cultivars of lupin seeds on colon cancer cells. The findings demonstrate that lupin cultivars can arrest cell cycles by inducing increased generation of intracellular reactive oxygen species and activation of caspases-3/7.
Article
Biochemistry & Molecular Biology
Meng Jia, Dengdeng Li, Rui Wang, Anqi Wang, Padraig Strappe, Qinghai Wu, Wenting Shang, Xuanyu Wang, Min Zhuang, Chris Blanchard, Zhongkai Zhou
Summary: The influence of phenolic compound extracts from three colored rice cultivars on the gut microbiota was investigated. The results revealed changes in the microbial structure and metabolites. Phenolic compounds promoted the growth of certain beneficial bacteria and inhibited the growth of harmful bacteria. The major fermentation products were propionate and acetate.