κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The BRG1/SOX9 axis is critical for acinar cell–derived pancreatic tumorigenesis

(2018) Motoyuki Tsuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

(2017) Peter Storz   Nature Reviews Gastroenterology & Hepatology

Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma

(2017) Katharina Stock et al.   Biomed Research International

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer

(2016) Chi-Hin Wong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

NFATc4 RegulatesSox9Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

(2016) Elisabeth Hessmann et al.   Stem Cells International

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas

(2015) Nai-Ming Chen et al.   GASTROENTEROLOGY

A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells

(2015) Hung Ping Shih et al.   Cell Reports

PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

(2015) S N Payne et al.   Oncogenesis

Constitutively Active Akt1 Cooperates with KRasG12D to Accelerate In Vivo Pancreatic Tumor Onset and Progression

(2015) Toya M. Albury et al.   NEOPLASIA

Critical role of NF-κB in pancreatic cancer

(2015) Lakshmi Prabhu et al.   Oncotarget

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

(2014) Romain Baer et al.   GENES & DEVELOPMENT

κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation

(2014) Andrea Oeckinghaus et al.   Cell Reports

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

(2013) Stefan Eser et al.   CANCER CELL

The Plastic Pancreas

(2013) Oren Ziv et al.   DEVELOPMENTAL CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

microRNA-140 Targets RALA and Regulates Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Translational Enhancement of SOX9 and ACAN

(2013) Tommy A. Karlsen et al.   STEM CELLS AND DEVELOPMENT

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia

(2012) Pierre-Paul Prévot et al.   GUT

The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector

(2012) N. F. Neel et al.   MOLECULAR AND CELLULAR BIOLOGY

Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

(2012) R Saito et al.   ONCOGENE

A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma

(2012) Eric A. Collisson et al.   Cancer Discovery

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers

(2011) Craig Dorrell et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network

(2011) Haoqiang Ying et al.   Cancer Discovery

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development

(2010) R. Hill et al.   CANCER RESEARCH

κB-Ras Is a Nuclear-Cytoplasmic Small GTPase That Inhibits NF-κB Activation through the Suppression of Transcriptional Activation of p65/RelA

(2010) Kenji Tago et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms

(2010) Dominico Vigil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

(2010) Xiao-Wei Chen et al.   MOLECULAR BIOLOGY OF THE CELL

IκBβ acts to inhibit and activate gene expression during the inflammatory response

(2010) Ping Rao et al.   NATURE

Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells

(2010) Amani Al-Adsani et al.   PLoS One

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

(2009) Sharon Y. Gidekel Friedlander et al.   CANCER CELL

Ras Activity Levels Control the Development of Pancreatic Diseases

(2009) Baoan Ji et al.   GASTROENTEROLOGY

Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases

(2009) Ryutaro Shirakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors

(2009) V. Bodempudi et al.   MOLECULAR AND CELLULAR BIOLOGY

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Regulation of Pancreas Plasticity and Malignant Transformation by Akt Signaling

(2008) Lynda Elghazi et al.   GASTROENTEROLOGY

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

(2008) N. Habbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA